PURPOSE
Women with Personal History of Breast Cancer (PHBC) face a higher risk of recurrence or new primary disease. The aim of this study was to present the results of the 'COMBO TRIAL,' a prospective intra-individual study evaluating the performance of Contrast- Enhanced Mammography (CEM) compared with Digital Mammography (DM) in the surveillance of women with PHBC.
MATERIAL AND METHODS
Between January 2023 and February 2025, 1551 asymptomatic women who underwent breast-conserving surgery ...
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with limited therapeutic options and poor prognosis. Although the complement system has long been considered a component of immune surveillance, accumulating evidence indicates its pro-tumoral role in several cancer types. In this thesis, we explored the contribution of complement activation to PDAC progression using preclinical pancreatic tumor models and animals deficient for C3-upstream (C1q-/-, C4-/-, MBL1/2-/-, fB-...
Il cancro al colon (CRC) comprende una famiglia complessa di tumori diversi per morfologia, infiltrazione del sistema immunitario, risposta ai farmaci e mutazioni genetiche, tra cui APC/KRAS/TP53/SMAD4. Le mutazioni nell'oncogene KRAS, soprattutto ai codoni 12 e 13, sono associate all'inizio e alla progressione del CRC, ma mancano in clinica di trattamenti bersaglio-specifici. Gli organoidi derivanti da pazienti (PDOs) sono stati dimostrati una nuova tecnologia di modello in vitro 3D utilizza...
Diffuse Large B-cell Lymphoma (DLBCL) represents the most common subtype of aggressive Non-Hodking Lymphoma (NHL). Bispecific antibodies (BsAbs) such as Glofitamab, have expanded therapeutic options for relapsed/refractory (R/R) DLBCL, including patients failing CAR-T. Despite high response rates, resistance and relapse remain major challenges, and current prognostic tools fail to accurately stratify patients and capture disease heterogeneity. In this context, circulating tumor DNA (ctDNA) an...
Interleukin-1 receptor 8 (IL-1R8) is an atypical Interleukin-1 receptor (ILR) family member that mitigates inflammatory responses by dampening ILR and Toll-like receptor (TLR) signaling. Studies conducted on IL-1R8-deficient NK cells established its key role as immune checkpoint and negative regulator of IL-18-dependent activation. In particular, IL-1R8-deficiency unleashes NK cell-mediated immune surveillance against hematogenous metastasis, liver cancer and viral dissemination. However, the...
BACKGROUND: Surgery with perioperative chemotherapy offers a potentially curative treatment for colorectal liver metastases (CRLM), but a subset of resectable patients does not achieve long-term benefit. Patient selection relies on survival prediction, but available prognostic factors have limited reliability. PURPOSE: To investigate the potential of preoperative CT-based radiomics for survival prediction in CRLM patients, focusing on the impact of CT-surgery interval and comparison with clin...
Neurodevelopmental disorders (NDDs) are a group of conditions including autism spectrum disorders (ASD). These disorders affect brain development and are characterized by social and cognitive deficits with onset in early life and long-lasting consequences. Several studies already demonstrated the genetic contribution to NDD risk, while more recently a strong impact of environmental factors, such as fever or other inflammatory insults, has emerged underlining a multifactorial origin. More spec...
Background
Glioblastoma (GBM) remains the most aggressive primary brain tumor in adults, char-acterized by poor prognosis and a high degree of therapeutic resistance. Despite ad-vances in surgery, radiotherapy, and temozolomide-based chemotherapy, median overall survival rarely exceeds 18 months. Radioresistance represents a major obstacle to effec-tive local control, often resulting from both intrinsic and adaptive cellular mechanisms. Among molecular mediators involved in DNA damage respons...
The Angelman Syndrome (AS) is a rare neurodevelopmental disorder caused by the loss of the maternally expressed UBE3A gene, which encodes an E3 ubiquitin ligase. Although considerable efforts have been put to dissect UBE3A function in the brain, the pathogenic mechanisms remain largely unknown and effective treatments are not available yet. Being an E3 ubiquitin ligase, defective ubiquitination, which may occur in either nuclear or cytosolic compartments, is thought to be a primary mechanism ...