The incidence and the lethality of pancreatic ductal adenocarcinoma (PDAC) is
alarmingly increasing in the last decades worldwide and novel therapies are urgently
needed to face this malignancy. In this project, we investigated the therapeutic potential
of poly(I:C) (pIC) and resiquimod (R848), two Toll-like receptor agonists, in different
preclinical models of PDAC. We found that, when used in combination, pIC+R848
elicit a potent antitumoral response in all the in vivo models investigated, ...
Purpose/Objective
The AuToMI project focuses on improving the TMLI clinical workflow and automating radiotherapy procedures through the application of Artificial Intelligence (AI). The primary goal is to streamline and enhance the efficiency of the radiotherapy treatment process by automating two critical steps: contouring of the target volumes and treatment plan optimization. In parallel, the project aims to integrate whole-body magnetic resonance imaging (WB-MRI) to improve the accuracy of ...
Purpose/Objective
The AuToMI project focuses on improving the TMLI clinical workflow and automating radiotherapy procedures through the application of Artificial Intelligence (AI). The primary goal is to streamline and enhance the efficiency of the radiotherapy treatment process by automating two critical steps: contouring of the target volumes and treatment plan optimization. In parallel, the project aims to integrate whole-body magnetic resonance imaging (WB-MRI) to improve the accuracy of ...
Purpose/Objective
The AuToMI project focuses on improving the TMLI clinical workflow and automating radiotherapy procedures through the application of Artificial Intelligence (AI). The primary goal is to streamline and enhance the efficiency of the radiotherapy treatment process by automating two critical steps: contouring of the target volumes and treatment plan optimization. In parallel, the project aims to integrate whole-body magnetic resonance imaging (WB-MRI) to improve the accuracy of ...
Malaria, caused by Plasmodium falciparum, remains a significant health burden, especially in tropical regions, as the parasite develops within human red blood cells (RBCs). The complement system initiates an early immune response against the parasite, but P. falciparum effectively evades complement-mediated killing. This study investigates how complement proteins deposit and are regulated on infected RBCs (iRBCs) and merozoites in the absence of parasite-specific antibodies. We show that fact...
Dilated cardiomyopathy (DCM) is a primary disease of the heart muscle, characterized by enlargement of the left
ventricle and systolic dysfunction, which results in progressive heart failure. Approximately 30-50% of cases are
familial and are caused by mutations in more than 50 different genes. Among these, sarcomeric protein Titin is
the most frequently associated with DCM, accounting for 25% of familiar cases. Although less frequent in DCM
cases (4-7%), mutations in LMNA gene, encoding ...
Dilated cardiomyopathy (DCM) is a primary disease of the heart muscle, characterized by enlargement of the left
ventricle and systolic dysfunction, which results in progressive heart failure. Approximately 30-50% of cases are
familial and are caused by mutations in more than 50 different genes. Among these, sarcomeric protein Titin is
the most frequently associated with DCM, accounting for 25% of familiar cases. Although less frequent in DCM
cases (4-7%), mutations in LMNA gene, encoding ...
Duchenne Muscular dystrophy (DMD) is a degenerative neuromuscular X-linked disease affecting 1 in 3,500-5,000 new-borns, whose life span is about 25-30 years old. DMD is generally caused by out-of-frame mutations in dystrophin (DMD) gene, leading to the absence of dystrophin protein. Dystrophin is the core part of a complex structure, this so called “dystrophin glycoprotein complex” (DGC), involved in calcium (Ca2+) homeostasis, mitochondrial function, motor protein interaction and muscle spe...
Duchenne Muscular dystrophy (DMD) is a degenerative neuromuscular X-linked disease affecting 1 in 3,500-5,000 new-borns, whose life span is about 25-30 years old. DMD is generally caused by out-of-frame mutations in dystrophin (DMD) gene, leading to the absence of dystrophin protein. Dystrophin is the core part of a complex structure, this so called “dystrophin glycoprotein complex” (DGC), involved in calcium (Ca2+) homeostasis, mitochondrial function, motor protein interaction and muscle spe...