Breast cancer is a multifaceted disease influenced by a variety of factors, including the tumor microenvironment and the host microbiota. Emerging evidence has highlighted the presence of intratumoral bacteria in different cancer types, with potential implications for tumor progression and immune modulation. In this study, we characterized an intratumoral Escherichia coli strain, E. coli T30, previously isolated from the 4T1 murine breast cancer model in our laboratory. Whole-genome sequencin...
Osteomyelitis (OM) is a severe musculoskeletal infection mainly caused by the opportunistic bacterium S. aureus (SA) that occurs after fracture, surgery, or secondary to vascular spread of the pathogen to skeletal sites. Several factors, including presence of foreign bodies (implants) and dysmetabolic diseases (diabetes), make the bone susceptible to infections. OM manifests with extensive tissue remodeling and inflammation. Host immune reactions and SA survival strategies coordinately affect...
The incidence and the lethality of pancreatic ductal adenocarcinoma (PDAC) is
alarmingly increasing in the last decades worldwide and novel therapies are urgently
needed to face this malignancy. In this project, we investigated the therapeutic potential
of poly(I:C) (pIC) and resiquimod (R848), two Toll-like receptor agonists, in different
preclinical models of PDAC. We found that, when used in combination, pIC+R848
elicit a potent antitumoral response in all the in vivo models investigated, ...
Purpose/Objective
The AuToMI project focuses on improving the TMLI clinical workflow and automating radiotherapy procedures through the application of Artificial Intelligence (AI). The primary goal is to streamline and enhance the efficiency of the radiotherapy treatment process by automating two critical steps: contouring of the target volumes and treatment plan optimization. In parallel, the project aims to integrate whole-body magnetic resonance imaging (WB-MRI) to improve the accuracy of ...
Purpose/Objective
The AuToMI project focuses on improving the TMLI clinical workflow and automating radiotherapy procedures through the application of Artificial Intelligence (AI). The primary goal is to streamline and enhance the efficiency of the radiotherapy treatment process by automating two critical steps: contouring of the target volumes and treatment plan optimization. In parallel, the project aims to integrate whole-body magnetic resonance imaging (WB-MRI) to improve the accuracy of ...
Purpose/Objective
The AuToMI project focuses on improving the TMLI clinical workflow and automating radiotherapy procedures through the application of Artificial Intelligence (AI). The primary goal is to streamline and enhance the efficiency of the radiotherapy treatment process by automating two critical steps: contouring of the target volumes and treatment plan optimization. In parallel, the project aims to integrate whole-body magnetic resonance imaging (WB-MRI) to improve the accuracy of ...
Malaria, caused by Plasmodium falciparum, remains a significant health burden, especially in tropical regions, as the parasite develops within human red blood cells (RBCs). The complement system initiates an early immune response against the parasite, but P. falciparum effectively evades complement-mediated killing. This study investigates how complement proteins deposit and are regulated on infected RBCs (iRBCs) and merozoites in the absence of parasite-specific antibodies. We show that fact...
Dilated cardiomyopathy (DCM) is a primary disease of the heart muscle, characterized by enlargement of the left
ventricle and systolic dysfunction, which results in progressive heart failure. Approximately 30-50% of cases are
familial and are caused by mutations in more than 50 different genes. Among these, sarcomeric protein Titin is
the most frequently associated with DCM, accounting for 25% of familiar cases. Although less frequent in DCM
cases (4-7%), mutations in LMNA gene, encoding ...
Dilated cardiomyopathy (DCM) is a primary disease of the heart muscle, characterized by enlargement of the left
ventricle and systolic dysfunction, which results in progressive heart failure. Approximately 30-50% of cases are
familial and are caused by mutations in more than 50 different genes. Among these, sarcomeric protein Titin is
the most frequently associated with DCM, accounting for 25% of familiar cases. Although less frequent in DCM
cases (4-7%), mutations in LMNA gene, encoding ...