Prospective evaluation of pro/anti-inflammatory cytokines during TKI treatment in chronic myeloid leukemia patients

Chronic myeloid leukemia (CML) treatment with tyrosine kinase inhibitors (TKIs) has been associated to an increased risk of Arterial Occlusive Events (AOEs), mainly with nilotinib, but the mechanisms underlying these events have been not clarified yet. Previously, we confirmed in our retrospective cross-sectional study a higher cardiovascular (CV) risk in nilotinib treated patients, particularly if harboring the unfavorable OLR1 polymorphism and we found a nilotinib-associated pro-inflammat...

Metabolic determinants of therapy resistance in estrogen receptor positive breast cancer

CfDNA-NGS Liquid Biopsy for solid cancers and vascular malformations

The liquid biopsy is a new emerging and repeatable low risky approach able to detect drive mutations that characterize the tumor, to monitor cancer evolution over time, and to overcome the standard tissue biopsy limits. The biomarker par excellence is the circulating cell-free DNA (cfDNA) that was the principal leading actor of this study. The scope of this study was to perform different liquid biopsy analysis both in metastatic cancer and in vascular malformations patients to detect, from a ...

Unraveling tandem repeat variation in personal genomes with long reads

Tandem repeats are repeated sequences that occur adjacent to each other in the human genome. Due to their prevalence and their association with a number of genetic diseases, there is a rising interest in developing tools for tandem repeat profiling. Genome-wide discovery approaches are needed to fully understand their roles in health and disease but resolving tandem repeat variation accurately remains a very challenging task. Indeed, while traditional mapping-based and assembly-based app...

"Females are not males: evolutionary strategies of the two sexes in chamois"

Vincoli evolutivi, fisiologici, anatomici potrebbero determinare diverse risposte individuali a fattori di stress ambientali (e.g. fattori climatici, stagionalità delle risorse), da parte di maschi e femmine. In ambienti montani, l'accesso a pascoli di alta qualità per gli erbivori è limitato ai mesi primaverili-estivi, rendendo così l’alimentazione estiva cruciale per la sopravvivenza invernale, in particolare per le femmine, che devono affrontare i costi della maternità, e per i nuovi nati....

Il "consenso" come veicolo della transizione digitale - Una necessaria armonizzazione tra reale e virtuale

Tumor microenvironment of Dark zone lymphomas

The TME plays a pivotal role in regulating the biology of GC B-cell lymphoma and immune escape strategies. Although there have been numerous studies investigating Lymphoma Microenvironment (LME) in B-cell lymphomas, the extent to which these TME differences reflect the stage of GC differentiation from which B cell lymphoma may originate remains poorly understood. Here we aim to compare the LME in 8 HGBCL-11q, 8 BL EBV-, 5 BL EBV+, 4 HGBCL-BCL2r/MYCr and 5 DLBCL-GCB, EBV-. GEP was ...

Persistent organic pollutants (POPs) in fish (Somniosus microcephalus, Gadus morhua, Gadus ogac, Reinhardtius hippoglossoides) from Greenland seawaters

Persistent organic pollutants (POPs) include several groups of industrial chemicals, pesticides or technical by-products with similar structures and chemical-physical properties. Their occurrence in Arctic wildlife has been documented since the beginning of the 1970s. The Arctic region is reported to be a "cold trap" for these chemicals that have been transported over long distances. In addition, due to the low temperature, limited biological activity and minimal incidence of sunlight, POP de...

STUDIO CHIMICO-FISICO MULTISCALA DI CONTESTI, PAESAGGI E REPERTI ARCHEOLOGICI: UN NUOVO APPROCCIO ARCHEOMETRICO Nuovi dati e approcci per la comprensione dei manufatti, dell'estrazione e lavorazione dei metalli delle dinamiche ambientali e del paesaggio storico delle Colline Metallifere

Archaeological surveys using physicochemical tools provide a new perspective on the study of human history through the investigation of ancient settlements. Despite the fact that information is often hidden due to changes in human and natural conditions (i.e. overlapping stratification, concurrent influences etc.), the chemical traces of past activities persists as fingerprints. A number of scientific methods applied on environmental matrices (i.e. soil, stream sediments, water, plants) can ...