Libera Università Vita-Salute San Raffaele di Milano

Libera Università Vita-Salute San Raffaele di Milano: [655] Istituto

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Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 101 a 120 di 655

Functional and molecular characterization of the role of mTOR pathway in neural stem cells both in vivo and in vitro

2011

Adult human Müller glia cells are a highly efficient source of rod photoreceptors

2011

Assessing the power of adherently expandable neural stem (NS) cells as tools to conduct focused and high-throughput studies of stem cell biology

2010

Genetic factors implicated in Alzheimerʼs disease (AD) and risk of conversion from mild cognitive impairment (MCI) to AD

2010

Dense-core vesicle gliosecretion is expressed heterogeneously by astrocytes under the control of the trascription repressor REST/NRSF dottorato di ricerca in molecular medicine

2010

The reciprocal regulation of macrophages and adult mesoangioblasts in damaged muscle influences their function and determine their fate

2010

Defining the peripheral nerve environment in amyotropich lateral sclerosis morphological studies in human motor biopsies and in the rat model

2010

Structural and functional brain abnormalities in neurodegenerative disorders assessed with MRI techniques

2011

The relationship between sensitivity to hypercapnia and panic disorder in a developmental perspective a genetically-informed study in general population twins

2010

Investigating the human sensory-motor system MRI studies on brain plasticity and motor resonance

2011

Discovery of genetic factors involved in multiple sclerosis susceptibility andtratment response PhD in molecular medicine, Section experimental neurology

2010

Role of the ATP1A2 gene in familial hemiplegic migraine type 2 development and characterization of genetically modified mouse models

2010

Human heat shock protein (Hsp) 90 protects human epithelial cells from Neisseria adhesin A (NadA)-mediated adhesion and invasion in vitro dottorato di ricerca in medicina molecolare

2010

Analysis of neurogenesis in developing and post-natal brains the role of ASPM and β-catenin

2010

Transplant site influences the immune response after islet transplantation bone marrow vs liver

2014

Defective crosstalk between iNKT cells and dendritic cells in type 1 diabetes

2014

Modulation of human macrophages microRNA expression profile upon infection with Mycobacterium tuberculosis

2013

Targeting the purinergic system in transplantation

2014

MTORC1 regulates polycystin-1 expression levels explaining the renal cystic phenotype in TSC

2014

Preclinical development of hematopoietic stem cell gene therapy for the treatment of globoid cell leukodystrophy

2014

Istituto	Anno di pubblicazione	Titolo	Autore
Libera Università Vita-Salute San Raffaele di Milano	2011	Functional and molecular characterization of the role of mTOR pathway in neural stem cells both in vivo and in vitro	-
Libera Università Vita-Salute San Raffaele di Milano	2011	Adult human Müller glia cells are a highly efficient source of rod photoreceptors	-
Libera Università Vita-Salute San Raffaele di Milano	2010	Assessing the power of adherently expandable neural stem (NS) cells as tools to conduct focused and high-throughput studies of stem cell biology	-
Libera Università Vita-Salute San Raffaele di Milano	2010	Genetic factors implicated in Alzheimerʼs disease (AD) and risk of conversion from mild cognitive impairment (MCI) to AD	-
Libera Università Vita-Salute San Raffaele di Milano	2010	Dense-core vesicle gliosecretion is expressed heterogeneously by astrocytes under the control of the trascription repressor REST/NRSF dottorato di ricerca in molecular medicine	-
Libera Università Vita-Salute San Raffaele di Milano	2010	The reciprocal regulation of macrophages and adult mesoangioblasts in damaged muscle influences their function and determine their fate	-
Libera Università Vita-Salute San Raffaele di Milano	2010	Defining the peripheral nerve environment in amyotropich lateral sclerosis morphological studies in human motor biopsies and in the rat model	-
Libera Università Vita-Salute San Raffaele di Milano	2011	Structural and functional brain abnormalities in neurodegenerative disorders assessed with MRI techniques	-
Libera Università Vita-Salute San Raffaele di Milano	2010	The relationship between sensitivity to hypercapnia and panic disorder in a developmental perspective a genetically-informed study in general population twins	-
Libera Università Vita-Salute San Raffaele di Milano	2011	Investigating the human sensory-motor system MRI studies on brain plasticity and motor resonance	-
Libera Università Vita-Salute San Raffaele di Milano	2010	Discovery of genetic factors involved in multiple sclerosis susceptibility andtratment response PhD in molecular medicine, Section experimental neurology	-
Libera Università Vita-Salute San Raffaele di Milano	2010	Role of the ATP1A2 gene in familial hemiplegic migraine type 2 development and characterization of genetically modified mouse models	-
Libera Università Vita-Salute San Raffaele di Milano	2010	Human heat shock protein (Hsp) 90 protects human epithelial cells from Neisseria adhesin A (NadA)-mediated adhesion and invasion in vitro dottorato di ricerca in medicina molecolare	-
Libera Università Vita-Salute San Raffaele di Milano	2010	Analysis of neurogenesis in developing and post-natal brains the role of ASPM and β-catenin	-
Libera Università Vita-Salute San Raffaele di Milano	2014	Transplant site influences the immune response after islet transplantation bone marrow vs liver	-
Libera Università Vita-Salute San Raffaele di Milano	2014	Defective crosstalk between iNKT cells and dendritic cells in type 1 diabetes	-
Libera Università Vita-Salute San Raffaele di Milano	2013	Modulation of human macrophages microRNA expression profile upon infection with Mycobacterium tuberculosis	-
Libera Università Vita-Salute San Raffaele di Milano	2014	Targeting the purinergic system in transplantation	-
Libera Università Vita-Salute San Raffaele di Milano	2014	MTORC1 regulates polycystin-1 expression levels explaining the renal cystic phenotype in TSC	-
Libera Università Vita-Salute San Raffaele di Milano	2014	Preclinical development of hematopoietic stem cell gene therapy for the treatment of globoid cell leukodystrophy	-

Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 101 a 120 di 655

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Prodotti recenti

Proliferative stress and DNA damage response pathways in hematopoietic stem cell gene therapy and clonal hematopoiesis

Gene editing (GE) of hematopoietic stem and progenitor cells (HSPCs) holds significant therapeutic promise but remains constrained by genotoxic risks associated with DNA double-strand breaks, donor template delivery, and proliferation-induced stress during ex vivo manipulation. Ex vivo culture is indispensable to achieve efficient homology-directed repair (HDR), yet comes at the cost of inducing cellular stress and compromising HSPC fitness. Here, we identify p38 MAPK signaling as a central r...

Studying human Hematopoietic Stem/Progenitor Cells Trafficking in vivo

Hematopoiesis, Gene Therapy

Unraveling the role of the alarmin HMGB1 in the ageing process

High Mobility Group Box 1 (HMGB1) is a nuclear protein that, in physiological conditions, is predominantly localized in the nucleus. Upon cellular stress, it can translocate to the cytosol and can be released extracellularly, where it regulates tissue regeneration and inflammatory responses in a redox-state-dependent manner. HMGB1 bioactivities has been associated with several hallmarks of aging, and HMGB1 has been recently proposed as a biomarker of frailty. Here we hypothesized that aging p...

Unravelling the role of Integrated Stress Response signalling in metastatic Breast Cancer bioenergetics

The Integrated Stress Response (ISR) is an evolutionarily conserved adaptive pathway that mediates translation reprogramming in response to microenvironmental stress, often hijacked by cancer cells to promote metastasis. To reveal novel targetable vulnerabilities in Triple-negative Breast Cancer (TNBC), the most aggressive breast cancer subtype, characterized by high metastatic propensity and limited therapeutic options, here we elucidate the mechanisms by which ISR accommodates the energy de...

AI-HOPE Lung cancer: building a predictive tool for metastatic lung cancer

Metastatic non-small-cell lung cancer (NSCLC) represents a heterogeneous disease with markedly variable outcomes, and reliable prognostic and predictive tools are urgently needed, particularly in the real-world setting. The AI-HOPE study was designed as an ambispective, multicentre project to collect real-world data and develop machine-learning models capable of predicting clinical endpoints in patients with metastatic NSCLC receiving first-line immunotherapy with or without chemotherapy. In ...

Leveraging real-world data with machine learning to disentangle the complexity of multimorbid internal medicine patients

The application of machine learning to healthcare real-world data is emerging as a complementary approach to clinical trials for enabling data-driven decision-making in the evolving population of complex patients managed in the internal medicine setting. To fully realise this potential, significant challenges remain, including data availability and quality limitations and the absence of standardized protocols for model development. In this thesis, we explore how to build an end-to-end machine...

Kant on Analogy: The Problem of Predicating the Noumenon in the Precritical Works

The dissertation aims to analyze Kant’s use of the concept of analogy in his precritical writings, while also reconstructing the historical development of the notion of analogy in order to provide a more accurate historical contextualization of Kant’s works. In doing so, it seeks to demonstrate that the characteristically critical concepts of regulative and constitutive knowledge can be traced back to the precritical period, specifically to Kant’s use of analogy as a means of addressing the p...

CLIMATE CHANGE AND MOTIVATION: VALUES, KNOWLEDGE, EDUCATION

sostenibilità, etica ambientale, filosofia morale, responsabilità individuale e collettiva, cambiamento climatico, educazione ambientale, educazione alla sostenibilità, comunicazione ambientale

The role of MFSD2A in the resolution of colorectal cancer-promoting inflammation: implications for innovative therapies

The intrinsic connection between inflammation and tumor promotion is well established and represents a key pathogenic factor in colorectal cancer (CRC). Therefore, reducing pro-inflammatory milieu without impairing physiological immune defenses or anti-tumor immunity becomes a desirable therapeutic strategy. Endogenous specialized pro-resolving mediators (SPMs), primarily derived from the ω-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid, actively promote th...

Studio degli effetti non cellulo-autonomi della mutazione p.A382T di TDP-43 nelle cellule di Schwann tramite l'utilizzo di un modello in vivo e di un modello in vitro

Il tratto neuropatologico distintivo della sclerosi laterale amiotrofica (SLA), una malattia neurodegenerativa caratterizzata dal coinvolgimento di primo e secondo motoneurone, è la mislocalizzazione, aggregazione e fosforilazione della proteina TDP-43, nota come patologia da TDP-43, nei tessuti affetti. In alcuni casi, nei pazienti con SLA vengono identificate mutazioni in TDP-43, suggerendo che questa proteina abbia un ruolo causale nella malattia. La variante missenso p.A382T è la più comu...

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