Interfering with mevalonate pathway to unleash effective antitumor response in melanoma

Immune checkpoint inhibitors (ICIs) have significantly improved survival in metastatic melanoma; however, most patients eventually experience disease progression and death. Emerging evidence suggests that statin therapy, widely prescribed for cardiovascular comorbidities, may potentiate ICIs efficacy, although the underlying mechanisms remain incompletely understood. Taking advantage of a unique clinical records of 66 patients with metastatic melanoma, including 20 receiving statin therapy c...

CONTROLLO COGNITIVO DURANTE IL SONNO: LO STRANO CASO DELL'AUTO-RISVEGLIO

Il presente progetto di dottorato esplora i meccanismi cognitivi e neurofisiologici alla base del fenomeno del self-awakening, definito come la capacità volontaria di svegliarsi a un’ora prestabilita senza stimoli esterni. Pur descritto già dal XIX secolo, tale fenomeno rimane poco studiato e raramente indagato con metodiche neurofisiologiche oggettive. Trenta adulti sani (20 non self-awakeners: 9 femmine, 11 maschi; età media 25 anni, e 10 self-awakeners: 4 femmine, 6 maschi; età media 23,5...

EXPLOITING CELLULAR IMMUNOTHERAPY STRATEGIES FOR PARKINSON’S DISEASE

Parkinson's disease (PD) is characterized by progressive neurodegeneration and chronic neuroinflammation driven by pathological -synuclein (Syn) accumulation. Regulatory T cells (Tregs) represent a promising therapeutic tool to restore immune homeostasis, however, their stability and antigen specificity are critical limitations. This study aimed to engineer Syn-specific chimeric antigen receptor (CAR) Tregs for targeted immunomodulation in PD. Initially, retroviral transduction of murine C...

Nuovi approcci della consulenza filosofica: il contributo trasformativo del pensiero religioso e dei linguaggi simbolici.

The Impact of Attentive System on Sleep Reactivity: A Study With a Participant-Applied Electroencephalography in the Home Environment

A comprehensive understanding of the processes leading to Insomnia Disorder (ID) is a crucial goal in clinical research. A central role is played by Sleep Reactivity (SR), described as the extent to which an individual tends to experience sleep disturbances following a stressful event. Heightened SR is one of the most robust predictors of the onset and persistence of ID. Cognitive processes also contribute to triggering and maintaining hyperarousal, and excessive attention to sleep-related cu...

Electrophysiological correlates of cognitive functions in Multiple Sclerosis

I metodi elettrofisiologici rappresentano strumenti preziosi per la rilevazione e il monitoraggio del deficit cognitivo nelle persone con Sclerosi Multipla (SM) e per la valutazione dell’efficacia dei trattamenti. Il Symbol Digit Modalities Test (SDMT), considerato il gold standard per lo screening della disfunzione cognitiva nella SM, risulta spesso compromesso in questi pazienti. Il nostro obiettivo è stato indagare i correlati elettrofisiologici e comportamentali dell’SDMT come indicatori ...

Identification and characterization of podocyte progenitor cells

Structural characterization of integrin-ligand interactions by NMR and computational methods

Advancing lentiviral vectors for liver-directed gene therapy