UNITesi

Libera Università Vita-Salute San Raffaele di Milano: [655] Istituto

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Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 81 a 100 di 655
Istituto Anno di pubblicazione Titolo Autore file(s)
Libera Università Vita-Salute San Raffaele di Milano 2016 Pathophysiological meaning of the paramagnetic rim in multiple sclerosis lesions a 7T MRI-pathology study -
Libera Università Vita-Salute San Raffaele di Milano 2016 Patient-specific induced pluripotent stem cells (iPSC) for ex vivo gene therapy and modelling of metachromatic leukodystrophy -
Libera Università Vita-Salute San Raffaele di Milano 2016 Smithian prudence and its relevance in moral philosophy and neuroscience -
Libera Università Vita-Salute San Raffaele di Milano 2016 La resistenza della materia studio sul rapporto tra corporeità e senso nell'antropologia filosofica di Helmuth Plessner -
Libera Università Vita-Salute San Raffaele di Milano 2016 Development of new strategies for improving microglia reconstitution after hematopoietic stem cell transplantation -
Libera Università Vita-Salute San Raffaele di Milano 2016 Harnessing the therapeutic improvements of genetically engineered neural stem cell in a preclinical model of multiple sclerosis -
Libera Università Vita-Salute San Raffaele di Milano 2016 Improving the safety of lentiviral vector integration with chromatin insulators -
Libera Università Vita-Salute San Raffaele di Milano 2016 Ontologia della trasfigurazione contributo allo studio della storia della filosofia russa -
Libera Università Vita-Salute San Raffaele di Milano 2016 Quatenus fit logica del sentire e logica del pensare in Antonio Rosmini e Giovanni Gentile -
Libera Università Vita-Salute San Raffaele di Milano 2015 HMGB1 and nucleosome number modulation in the transcriptional response to stress -
Libera Università Vita-Salute San Raffaele di Milano 2015 Role of the ERAD pathway in the physiology and disease of peripheral nerves myelination -
Libera Università Vita-Salute San Raffaele di Milano 2012 Genetics of premature ovarian failure and early menopause -
Libera Università Vita-Salute San Raffaele di Milano 2011 Anti-apoptotic effects of interleukin 7 in human immunodeficiency virus type 1 infection mechanism and implications for immune reconstitution strategies -
Libera Università Vita-Salute San Raffaele di Milano 2011 Interaction with CD1d-expressing APCs regulate iNKT cell functions by tuning SHP-1 expression -
Libera Università Vita-Salute San Raffaele di Milano 2011 Identification of mechanisms of immunosuppression in a spontaneous model of prostate cancer -
Libera Università Vita-Salute San Raffaele di Milano 2011 Investigating genes directly regulated by atrophin -
Libera Università Vita-Salute San Raffaele di Milano 2011 Intracellular and paracrine effects of alpha-synuclein on the structure and dynamics of the actin cytoskeleton -
Libera Università Vita-Salute San Raffaele di Milano 2010 Il concetto di epoca fra illuminismo e romanticismo -
Libera Università Vita-Salute San Raffaele di Milano 2010 L'orizzonte in movimento modernità  e futuro in Reinhart Koselleck -
Libera Università Vita-Salute San Raffaele di Milano 2011 HMGB1 and neuroinflammation cerebral ischemia and epilepsy -
Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 81 a 100 di 655
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Prodotti recenti

Proliferative stress and DNA damage response pathways in hematopoietic stem cell gene therapy and clonal hematopoiesis

Gene editing (GE) of hematopoietic stem and progenitor cells (HSPCs) holds significant therapeutic promise but remains constrained by genotoxic risks associated with DNA double-strand breaks, donor template delivery, and proliferation-induced stress during ex vivo manipulation. Ex vivo culture is indispensable to achieve efficient homology-directed repair (HDR), yet comes at the cost of inducing cellular stress and compromising HSPC fitness. Here, we identify p38 MAPK signaling as a central r...

Studying human Hematopoietic Stem/Progenitor Cells Trafficking in vivo

Hematopoiesis, Gene Therapy

Unraveling the role of the alarmin HMGB1 in the ageing process

High Mobility Group Box 1 (HMGB1) is a nuclear protein that, in physiological conditions, is predominantly localized in the nucleus. Upon cellular stress, it can translocate to the cytosol and can be released extracellularly, where it regulates tissue regeneration and inflammatory responses in a redox-state-dependent manner. HMGB1 bioactivities has been associated with several hallmarks of aging, and HMGB1 has been recently proposed as a biomarker of frailty. Here we hypothesized that aging p...

Unravelling the role of Integrated Stress Response signalling in metastatic Breast Cancer bioenergetics

The Integrated Stress Response (ISR) is an evolutionarily conserved adaptive pathway that mediates translation reprogramming in response to microenvironmental stress, often hijacked by cancer cells to promote metastasis. To reveal novel targetable vulnerabilities in Triple-negative Breast Cancer (TNBC), the most aggressive breast cancer subtype, characterized by high metastatic propensity and limited therapeutic options, here we elucidate the mechanisms by which ISR accommodates the energy de...

AI-HOPE Lung cancer: building a predictive tool for metastatic lung cancer

Metastatic non-small-cell lung cancer (NSCLC) represents a heterogeneous disease with markedly variable outcomes, and reliable prognostic and predictive tools are urgently needed, particularly in the real-world setting. The AI-HOPE study was designed as an ambispective, multicentre project to collect real-world data and develop machine-learning models capable of predicting clinical endpoints in patients with metastatic NSCLC receiving first-line immunotherapy with or without chemotherapy. In ...

Leveraging real-world data with machine learning to disentangle the complexity of multimorbid internal medicine patients

The application of machine learning to healthcare real-world data is emerging as a complementary approach to clinical trials for enabling data-driven decision-making in the evolving population of complex patients managed in the internal medicine setting. To fully realise this potential, significant challenges remain, including data availability and quality limitations and the absence of standardized protocols for model development. In this thesis, we explore how to build an end-to-end machine...

Kant on Analogy: The Problem of Predicating the Noumenon in the Precritical Works

The dissertation aims to analyze Kant’s use of the concept of analogy in his precritical writings, while also reconstructing the historical development of the notion of analogy in order to provide a more accurate historical contextualization of Kant’s works. In doing so, it seeks to demonstrate that the characteristically critical concepts of regulative and constitutive knowledge can be traced back to the precritical period, specifically to Kant’s use of analogy as a means of addressing the p...

CLIMATE CHANGE AND MOTIVATION: VALUES, KNOWLEDGE, EDUCATION

sostenibilità, etica ambientale, filosofia morale, responsabilità individuale e collettiva, cambiamento climatico, educazione ambientale, educazione alla sostenibilità, comunicazione ambientale

The role of MFSD2A in the resolution of colorectal cancer-promoting inflammation: implications for innovative therapies

The intrinsic connection between inflammation and tumor promotion is well established and represents a key pathogenic factor in colorectal cancer (CRC). Therefore, reducing pro-inflammatory milieu without impairing physiological immune defenses or anti-tumor immunity becomes a desirable therapeutic strategy. Endogenous specialized pro-resolving mediators (SPMs), primarily derived from the ω-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid, actively promote th...

Studio degli effetti non cellulo-autonomi della mutazione p.A382T di TDP-43 nelle cellule di Schwann tramite l'utilizzo di un modello in vivo e di un modello in vitro

Il tratto neuropatologico distintivo della sclerosi laterale amiotrofica (SLA), una malattia neurodegenerativa caratterizzata dal coinvolgimento di primo e secondo motoneurone, è la mislocalizzazione, aggregazione e fosforilazione della proteina TDP-43, nota come patologia da TDP-43, nei tessuti affetti. In alcuni casi, nei pazienti con SLA vengono identificate mutazioni in TDP-43, suggerendo che questa proteina abbia un ruolo causale nella malattia. La variante missenso p.A382T è la più comu...

Scopri
Istituto
  • Libera Università Vita-Salute San...647
Data di pubblicazione
  • 2020 - 2026258
  • 2010 - 2019355
  • 2001 - 200942
Settore disciplinare
  • Settore BIO/11 - Biologia Molecolare81
  • Settore BIO/13 - Biologia Applicata75
  • Settore MED/26 - Neurologia70
  • Settore MED/04 - Patologia Generale62
  • Settore M-FIL/01 - Filosofia Teor...18
  • Settore MED/15 - Malattie del Sangue18
  • Settore M-PSI/02 - Psicobiologia ...17
  • Settore MED/25 - Psichiatria14
  • Settore M-FIL/03 - Filosofia Morale12
  • Settore M-FIL/06 - Storia della F...12
Accesso al fulltext
  • no fulltext318
  • open221
  • internalNetwork68
  • embargoed29
  • reserved6
  • mixed5