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Libera Università Vita-Salute San Raffaele di Milano: [285] Istituto

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Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 121 a 140 di 285
Istituto Anno di pubblicazione Titolo Autore file(s)
Libera Università Vita-Salute San Raffaele di Milano 2009 Functional characterization of the TEL-AML1 pre-leukaemic clone. -
Libera Università Vita-Salute San Raffaele di Milano 2008 Combining vascular targeting, chemotherapy and active immunotherapy as a novel therapeutic strategy for prostate cancer. -
Libera Università Vita-Salute San Raffaele di Milano 2008 Pathophysiology of the mammalian COP9 signalosome : insights from conditional deletion of CSN5/JAB1 in T cells and hepatocytes. -
Libera Università Vita-Salute San Raffaele di Milano 2009 Chromogranin-A and its proteolytic fragment vasostatin-1. regulate sustained TNF-Alpha-mediated vascular inflammation in patients with rheumatoid arthritis and giant cell arteritis. Pathogenetic and clinical implications. -
Libera Università Vita-Salute San Raffaele di Milano 2004 Functional and biochemical characterization of EFA6As, a protein involved in cytoskeletal remodeling in neuronal cells. -
Libera Università Vita-Salute San Raffaele di Milano 2004 Molecular mechanisms of immune deficiency in adenosine deaminase (ADA)-deficient scid patients : implications for stem cell gene therapy. -
Libera Università Vita-Salute San Raffaele di Milano 2008 Development of new lentiviral vectors for coordinate or self-regulated gene expression and application to CNS delivery. -
Libera Università Vita-Salute San Raffaele di Milano 2007 Natural killer cells and HLA-haplotype mismatched haematopoietic stem cell transplantation. -
Libera Università Vita-Salute San Raffaele di Milano 2007 Subcellular microdomains in T cell development. -
Libera Università Vita-Salute San Raffaele di Milano 2007 Identification of pericytes as myogenic precursors in human skeletal muscle. -
Libera Università Vita-Salute San Raffaele di Milano 2017 Human STAT1 deficiencies. -
Libera Università Vita-Salute San Raffaele di Milano 2009 Microglia at the interface between inflammation and neurodegeneration. -
Libera Università Vita-Salute San Raffaele di Milano 2004 Role of covalent modifications in PrP folding and maturation : biological and pathological implications. -
Libera Università Vita-Salute San Raffaele di Milano 2008 The relation between HMGB1 immobilization and other nuclear processes during apoptosis. -
Libera Università Vita-Salute San Raffaele di Milano 2008 Molecular physiology of plasma cell differentiation. -
Libera Università Vita-Salute San Raffaele di Milano 2008 Human MyD88 deficiency. -
Libera Università Vita-Salute San Raffaele di Milano 2008 Regulated exocytosis of enlargeosomes, a unique process mediated by VAMP4 and followed by endocytosis, membrane shedding or both. -
Libera Università Vita-Salute San Raffaele di Milano 2009 Non-myeloablative allotransplantation combined with tumour-specific vaccination for the treatment of prostate cancer. -
Libera Università Vita-Salute San Raffaele di Milano 2008 Dynamics and oligomerization of urokinase plasminogen activator receptor (uPAR) : a GPI-anchored receptor studied by fluorescence micro-spectroscopy. -
Libera Università Vita-Salute San Raffaele di Milano 2008 Structure and dynamics of high mobility group box protein 1 (HMGB1) complexed with inhibitors of its proinflammatory activity : a combined nuclear magnetic resonance and computational chemistry approach. -
Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 121 a 140 di 285
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La malattia di Charcot-Marie-Tooth (CMT) è la neuropatia periferica ereditaria più frequentemente osservata, con una prevalenza di circa 1 su 2.500 persone. È un gruppo di patologie geneticamente eterogeneo, con mutazioni in oltre 100 geni, che colpisce sia i nervi motori sia quelli sensoriali. La mutazione T124M nel gene MPZ dà origine alla CMT2J, un sottotipo particolarmente interessante con una particolare prevalenza nell’Italia settentrionale. Sebbene MPZ sia una proteina esclusivamente e...

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Imaging, genetic and biomarkers characterization of arrhythmic mitral valve prolapse

Association between genotype and phenotype in mitral valve prolapse patients and their impact on arrhythmic outcomes

Digital Cognitive Assessment and its Relationship with Disability in Multiple Sclerosis

Introduction. Cognitive impairment is common in people with MS (pwMS) and significantly impacts functional independence. The Symbol-Digit Modalities Test (SDMT) is widely used to assess cognitive deficits in pwMS. Electronic adaptations of the SDMT (eSDMT) can enable remote monitoring and capture more detailed performance metrics, compared to pen-and-paper tests. This study details the development and validation of a custom-made eSDMT intended to enable long-term remote cognitive monitoring o...

At-home extension of computerised cognitive rehabilitation in People with Progressive Multiple Sclerosis: A Feasibility and Efficacy Pilot Randomised Controlled Trial

A great proportion of People with Multiple Sclerosis (PwMS) suffers from Cognitive Impairment (CI), which greatly diminishes the quality of life of those affected. Pharmacological treatments for CI in PwMS showed limited efficacy, and behaviourally-based interventions still remain the preferred care option. These typically involve in-clinic repeated one-on-one sessions with a therapist for a set period of time. This has been seen to be both costly and unfeasible for some PwMS. Telerehabilitat...

FUTURE-MAKER-GENERATIONS. CRITICAL PHENOMENOLOGY AND TRANSGENERATIVE SOCIAL ONTOLOGY

This thesis introduces the concept of Future-Maker Generations (FMGs), a novel form of plural subject described as an ethical and political community, globally disseminated and axiologically oriented towards the defence of plurality of all forms of life. The thesis aims to describe and analyse the emerging of FMGs from Future-Maker Personalities (FMPs), individuals united by a shared set of values oriented towards human plurality, global solidarity, human rights, and environmental protection....

LNA-ASO based therapy for the treatment of SARS-CoV-2 infection in pre-clinicals models

The COVID-19 crisis and the development of the first approved mRNA vaccine have highlighted the potential of RNA-based therapeutic strategies. Mutated variant strains of SARS-CoV-2 that evade immunity to previous infection or vaccination are continuously emerging, resulting in new outbreaks. Thus, there is a clear and urgent need for alternative approaches that are active against multiple variants of concern. Antisense oligonucleotides (ASOs) represent a new and promising class of RNA-targete...

Pregnancy during a pandemic: a deep phenotyping approach exploring the role of inflammation on postpartum cognitive decline and depression.

Peripartum depression (PPD) results in physical, emotional, and behavioral changes during pregnancy and postpartum that occur in roughly 20% of women, yet COVID-19 may have increased the prevalence of PPD. Furthermore, during this period, women may be vulnerable to the development of cognitive deficits. The biological causes of PPD and cognitive decline are still unclear. These issues may arise due to brain structural and functional alterations; however, results are inconclusive. Moreover, dy...

FUNCTIONAL AND STRUCTURAL MRI CORRELATES OF COGNITIVE DYSFUNCTION IN PEDIATRIC MS AND A COMPARISON OF COGNITIVE RESILIENCE WITH ADULT-ONSET MS

During my PhD, I focused on the study of the MRI substrates of cognition in pediatric-onset (PO) multiple sclerosis (MS) patients and on the validation of a novel paper-pencil cognitive test, the Consecutive-letter Substitution Test (CST), to assess information processing speed (IPS). By applying unsupervised machine learning, we identified three cognitive phenotypes in pediatric MS patients: normal functioning, mild verbal memory and semantic fluency deficits, and global impairment, each as...

Trust, Science and Disinformation

In this dissertation, my aim is to analyse the reasons and causes behind the spread of disinformation. In particular, my main interest is in what I will refer to as “scientific disinformation”, namely the kind of disinformation that regards scientific issues and topics, with a particular focus on climate change. The thesis is divided into five chapters, each with a specific purpose. The first chapter is dedicated to the definition of disinformation. I review the different definitions of disin...

Scopri
Istituto
  • Libera Università Vita-Salute San...285
Data di pubblicazione
  • 2020 - 2025200
  • 2010 - 201944
  • 2004 - 200941
Settore disciplinare
  • Settore BIO/11 - Biologia Molecolare31
  • Settore MED/26 - Neurologia21
  • Settore BIO/13 - Biologia Applicata20
  • Settore MED/04 - Patologia Generale20
  • Settore M-PSI/02 - Psicobiologia ...8
  • Settore MED/25 - Psichiatria7
  • Settore M-FIL/01 - Filosofia Teor...5
  • Settore M-FIL/03 - Filosofia Morale4
  • Settore M-FIL/05 - Filosofia e Te...4
  • Settore MED/15 - Malattie del Sangue4
Accesso al fulltext
  • open158
  • internalNetwork68
  • embargoed36
  • no fulltext10
  • mixed7
  • reserved6