Libera Università Vita-Salute San Raffaele di Milano

Libera Università Vita-Salute San Raffaele di Milano: [661] Istituto

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Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 201 a 220 di 661

Visual evoked potentials as biomarkers to monitor optic nerve involvement in EAE models of multiple sclerosis

2018

Governamentalità e verità uno studio sul problema del governo in Michel Foucault

2018

Towards obsessive compulsive disorder heterogeneity a neuropsychological perspective

2014

CD44 isoform variant 6 acts as a redox rheostat in normal and malignant hematopoiesis

2014

PNRC1 affects rRNA dynamics by recruiting a cytoplasmic RNA decapping and decay machinery inside nucleoli

2014

Whole exome sequencing and RNA sequencing approaches for the identification of new pain-related genes in familial and sporadic patients affected by painful and painless idiopathic peripheral neuropathy

2017

The role of B cell receptor and microenvironment in chronic lymphocytic leukemia new mechanisms and tools to unravel hallmarks of cancer development

2017

Development and optimization of multicolor 19F-MRI for in vivo imaging of immune cells activity

2017

Role of genetic predisposition and endogenous ouabain in acute kidney injury

2017

Study on the role of microglia in acute experimental stroke

2017

The unfolded protein response switches from pro-survival to pro-apoptotic to cap the extent of endoplasmic reticulum expansion

2017

Engineering hematopoiesis for tumor-targeted interferon-alpha delivery to promote anti-cancer responses

2016

The histone methyltransferase NSD3 sustains rRNA transcription in cancer cells

2016

Re-establishing immunological tolerance in type 1 diabetes by lentiviral vector gene transfer

2014

Which epistemology for applied mathematics? from classical debates to structural accounts

2016

An SLC9A9 variant influences the disease activity in interferon-treated multiple sclerosis patients

2013

Soggetto e significazione della rinascita di un concetto

2014

Strategies targeting innate or adaptive immunity to control type 1 diabetes

2013

On the regulation of antibody responses by T follicular helper cells

2014

Characterization of shedding vesicles released by M1 and M2 activated macrophages

2013

Istituto	Anno di pubblicazione	Titolo	Autore
Libera Università Vita-Salute San Raffaele di Milano	2018	Visual evoked potentials as biomarkers to monitor optic nerve involvement in EAE models of multiple sclerosis	-
Libera Università Vita-Salute San Raffaele di Milano	2018	Governamentalità e verità uno studio sul problema del governo in Michel Foucault	-
Libera Università Vita-Salute San Raffaele di Milano	2014	Towards obsessive compulsive disorder heterogeneity a neuropsychological perspective	-
Libera Università Vita-Salute San Raffaele di Milano	2014	CD44 isoform variant 6 acts as a redox rheostat in normal and malignant hematopoiesis	-
Libera Università Vita-Salute San Raffaele di Milano	2014	PNRC1 affects rRNA dynamics by recruiting a cytoplasmic RNA decapping and decay machinery inside nucleoli	-
Libera Università Vita-Salute San Raffaele di Milano	2017	Whole exome sequencing and RNA sequencing approaches for the identification of new pain-related genes in familial and sporadic patients affected by painful and painless idiopathic peripheral neuropathy	-
Libera Università Vita-Salute San Raffaele di Milano	2017	The role of B cell receptor and microenvironment in chronic lymphocytic leukemia new mechanisms and tools to unravel hallmarks of cancer development	-
Libera Università Vita-Salute San Raffaele di Milano	2017	Development and optimization of multicolor 19F-MRI for in vivo imaging of immune cells activity	-
Libera Università Vita-Salute San Raffaele di Milano	2017	Role of genetic predisposition and endogenous ouabain in acute kidney injury	-
Libera Università Vita-Salute San Raffaele di Milano	2017	Study on the role of microglia in acute experimental stroke	-
Libera Università Vita-Salute San Raffaele di Milano	2017	The unfolded protein response switches from pro-survival to pro-apoptotic to cap the extent of endoplasmic reticulum expansion	-
Libera Università Vita-Salute San Raffaele di Milano	2016	Engineering hematopoiesis for tumor-targeted interferon-alpha delivery to promote anti-cancer responses	-
Libera Università Vita-Salute San Raffaele di Milano	2016	The histone methyltransferase NSD3 sustains rRNA transcription in cancer cells	-
Libera Università Vita-Salute San Raffaele di Milano	2014	Re-establishing immunological tolerance in type 1 diabetes by lentiviral vector gene transfer	-
Libera Università Vita-Salute San Raffaele di Milano	2016	Which epistemology for applied mathematics? from classical debates to structural accounts	-
Libera Università Vita-Salute San Raffaele di Milano	2013	An SLC9A9 variant influences the disease activity in interferon-treated multiple sclerosis patients	-
Libera Università Vita-Salute San Raffaele di Milano	2014	Soggetto e significazione della rinascita di un concetto	-
Libera Università Vita-Salute San Raffaele di Milano	2013	Strategies targeting innate or adaptive immunity to control type 1 diabetes	-
Libera Università Vita-Salute San Raffaele di Milano	2014	On the regulation of antibody responses by T follicular helper cells	-
Libera Università Vita-Salute San Raffaele di Milano	2013	Characterization of shedding vesicles released by M1 and M2 activated macrophages	-

Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 201 a 220 di 661

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Prodotti recenti

Studying immunometabolic alterations in age-related diseases

The tricarboxylic acid (TCA) cycle is a core metabolic pathway for the generation of mitochondrial ATP and key anabolic intermediates in cells. Succinate dehydrogenase (SDH), the enzymatic complex that catalyzes the oxidation of succinate to fumarate in the TCA cycle, stands as the first mitochondrial enzyme found mutated in cancer. Loss of SDH function disrupts the TCA cycle and triggers succinate accumulation in tumor cells. However, how tumors cope with a dysfunctional TCA cycle remains la...

VALIDATION OF ARTIFICIAL EPIGENETIC SILENCER TO REDUCE GLIOBLASTOMA IN IMMUNOCOMPETENT MOUSE MODEL

Glioblastoma (GBM) is the most aggressive primary brain tumor in adults and remains associated with extremely poor prognosis despite multimodal treatment, including surgery, radiotherapy, and chemotherapy. The limited efficacy of current therapies reflects key features of this malignancy, including marked inter- and intra-tumoral heterogeneity, highly infiltrative growth, and the strong influence of the tumor microenvironment on disease progression and therapeutic response. In particular, the...

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Terapia genica tramite editing con HDR su cellule staminali emopoietiche

Svelare l’impatto del microbiota sulla fibrosi intestinale: nuove prospettive per la patogenesi e il trattamento delle complicanze associate al morbo di Crohn.

Complicanze fibrotiche della malattia di Crohn

Lo standard setting delle organizzazioni internazionali per la Pubblica Amministrazione nell'epoca della fine dell'ordine globale neoliberale

La tesi analizza l'impatto dello standard setting delle organizzazioni internazionali (in particolare delle Nazioni Unite) per la pubblica amministrazione nell'attuale scenario di fine dell'ordine globale neoliberale.

REFORMING COMMUNICATION IN PUBLIC ADMINISTRATION: A RESEARCH ON INCLUSIVE LANGUAGE

Linguaggio inclusivo di genere

Proliferative stress and DNA damage response pathways in hematopoietic stem cell gene therapy and clonal hematopoiesis

Gene editing (GE) of hematopoietic stem and progenitor cells (HSPCs) holds significant therapeutic promise but remains constrained by genotoxic risks associated with DNA double-strand breaks, donor template delivery, and proliferation-induced stress during ex vivo manipulation. Ex vivo culture is indispensable to achieve efficient homology-directed repair (HDR), yet comes at the cost of inducing cellular stress and compromising HSPC fitness. Here, we identify p38 MAPK signaling as a central r...

Studying human Hematopoietic Stem/Progenitor Cells Trafficking in vivo

Hematopoiesis, Gene Therapy

Unraveling the role of the alarmin HMGB1 in the ageing process

High Mobility Group Box 1 (HMGB1) is a nuclear protein that, in physiological conditions, is predominantly localized in the nucleus. Upon cellular stress, it can translocate to the cytosol and can be released extracellularly, where it regulates tissue regeneration and inflammatory responses in a redox-state-dependent manner. HMGB1 bioactivities has been associated with several hallmarks of aging, and HMGB1 has been recently proposed as a biomarker of frailty. Here we hypothesized that aging p...

Unravelling the role of Integrated Stress Response signalling in metastatic Breast Cancer bioenergetics

The Integrated Stress Response (ISR) is an evolutionarily conserved adaptive pathway that mediates translation reprogramming in response to microenvironmental stress, often hijacked by cancer cells to promote metastasis. To reveal novel targetable vulnerabilities in Triple-negative Breast Cancer (TNBC), the most aggressive breast cancer subtype, characterized by high metastatic propensity and limited therapeutic options, here we elucidate the mechanisms by which ISR accommodates the energy de...

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