UNITesi

Libera Università Vita-Salute San Raffaele di Milano: [285] Istituto

Sfoglia
Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 181 a 200 di 285
Istituto Anno di pubblicazione Titolo Autore file(s)
Libera Università Vita-Salute San Raffaele di Milano 2021 DIFFERENCES IN BRAIN STRUCTURE AND FUNCTION IN PRIMARY HEADACHE DISORDERS: A MULTIMODAL MRI STUDY -
Libera Università Vita-Salute San Raffaele di Milano 2024 I macrofagi IL-1b+ alimentano l'infiammazione patogena nel tumore al pancreas -
Libera Università Vita-Salute San Raffaele di Milano 2022 Investigating liver tissue dynamics to improve in vivo gene therapy -
Libera Università Vita-Salute San Raffaele di Milano 2022 UTERINE FLUID EXTRACELLULAR VESICLES AS A LIQUID BIOPSY FOR THE DIAGNOSIS OF ENDOMETRIAL RECEPTIVITY -
Libera Università Vita-Salute San Raffaele di Milano 2024 MOBILIZATION-BASED CHEMOTHERAPY-FREE ENGRAFTMENT OF GENE EDITED HEMATOPOIETIC STEM CELLS -
Libera Università Vita-Salute San Raffaele di Milano 2024 Caratterizzazione di un modello murine di Mucopolisaccaridosi oer lo sviluppo pre-clinico di strategie per la terapia genica -
Libera Università Vita-Salute San Raffaele di Milano 2021 CARATTERIZZAZIONE DEI MECCANISMI MOLECOLARI CHE CONTROLLANO L'ESPRESSIONE DI GENI INFIAMMATORI NEI MACROFAGI -
Libera Università Vita-Salute San Raffaele di Milano 2022 ENDOSCOPY-BASED INVESTIGATION OF NOVEL BIOMARKERS FOR PANCREATIC CANCER -
Libera Università Vita-Salute San Raffaele di Milano 2024 ENDOSCOPIC ULTRASOUND BEYOND MORPHOLOGY: FEASIBILITY OF TRANSCRIPTOMIC ANALYSIS AND THE ROLE OF DEEP LEARNING MODELS AND MICROVASCULARIZATION STUDY IN THE DIAGNOSIS AND PROGNOSIS OF PANCREATIC NEUROENDOCRINE NEOPLASMS -
Libera Università Vita-Salute San Raffaele di Milano 2024 INTEGRATING PSMA EXPRESSION PATTERNS, MORPHOLOGICAL AND CLINICAL FEATURES TO OPTIMIZE DETECTION OF NODAL METASTASES IN PATIENTS TREATED WITH PSMA RADIO-GUIDED ROBOT-ASSISTED RADICAL PROSTATECTOMY AND EXTENDED PELVIC LYMPH NODE DISSECTION -
Libera Università Vita-Salute San Raffaele di Milano 2022 MAPPING STRUCTURAL AND FUNCTIONAL MRI CORRELATES OF CLINICAL DISABILITY AND COGNITIVE IMPAIRMENT IN PEDIATRIC MS -
Libera Università Vita-Salute San Raffaele di Milano 2021 DYNAMICS OF CD8+ T CELL DYSFUNCTIONAL DIFFERENTIATION UPON INTRAHEPATIC PRIMING AND MECHANISMS OF IL-2 MEDIATED RESTORATION -
Libera Università Vita-Salute San Raffaele di Milano 2023 Defining intrahepatic T cell priming events responsible for defective T cell responses -
Libera Università Vita-Salute San Raffaele di Milano 2024 Cutting-edge transcriptomics to identify leukemia-intrinsic and - extrinsic correlates of defined patterns of immune escape and post- transplantation relapse -
Libera Università Vita-Salute San Raffaele di Milano 2023 ERC1-CONTROLLED PROTEIN CONDENSATES TO REGULATE CELL MIGRATION AND INVASION -
Libera Università Vita-Salute San Raffaele di Milano 2022 TRACKING AND PREDICTING NEURODEGENERATION SPREADING IN SPORADIC AND GENETIC PRESENTATIONS OF THE ALS/FTD CONTINUUM -
Libera Università Vita-Salute San Raffaele di Milano 2024 Identificazione EUS-guidata di Cellule Tumorali Circolanti nel sangue portale di pazienti con cancro al pancreas: caratterizzazione, profilazione e potenziale ruolo prognostico -
Libera Università Vita-Salute San Raffaele di Milano 2022 Axonal mRNA dysregulation in a cellular model of TDP-43 proteinopathy: a functional and -omic analysis -
Libera Università Vita-Salute San Raffaele di Milano 2022 INVESTIGATING HEALTHY AND PATHOLOGICAL AGING THROUGH MULTIMODAL MRI CONNECTOMICS -
Libera Università Vita-Salute San Raffaele di Milano 2022 Simplification of prostate MRI protocol and development of a novel MRI technique for prostate cancer detection and characterization -
Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 181 a 200 di 285
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Prodotti recenti

Degenerazione assonale nelle neuropatie periferiche: dai meccanismi molecolari all’approccio terapeutico

La malattia di Charcot-Marie-Tooth (CMT) è la neuropatia periferica ereditaria più frequentemente osservata, con una prevalenza di circa 1 su 2.500 persone. È un gruppo di patologie geneticamente eterogeneo, con mutazioni in oltre 100 geni, che colpisce sia i nervi motori sia quelli sensoriali. La mutazione T124M nel gene MPZ dà origine alla CMT2J, un sottotipo particolarmente interessante con una particolare prevalenza nell’Italia settentrionale. Sebbene MPZ sia una proteina esclusivamente e...

Lo studio dell'età cellulare sulla funzione delle β cellule derivate da iPSC

Una fonte affidabile di β cellule è essenziale per l'avanzamento della terapia cellulare nel diabete di tipo 1. Le cellule staminali pluripotenti indotte possono differenziarsi in β cellule produttrici di insulina, imitando efficacemente lo sviluppo pancreatico in vitro. Mentre la senescenza cellulare supporta la formazione di β cellule durante l'embriogenesi, la loro senescenza cellulare legata all'invecchiamento compromette il rilevamento del glucosio e la secrezione di insulina. Tuttavia, ...

Imaging, genetic and biomarkers characterization of arrhythmic mitral valve prolapse

Association between genotype and phenotype in mitral valve prolapse patients and their impact on arrhythmic outcomes

Digital Cognitive Assessment and its Relationship with Disability in Multiple Sclerosis

Introduction. Cognitive impairment is common in people with MS (pwMS) and significantly impacts functional independence. The Symbol-Digit Modalities Test (SDMT) is widely used to assess cognitive deficits in pwMS. Electronic adaptations of the SDMT (eSDMT) can enable remote monitoring and capture more detailed performance metrics, compared to pen-and-paper tests. This study details the development and validation of a custom-made eSDMT intended to enable long-term remote cognitive monitoring o...

At-home extension of computerised cognitive rehabilitation in People with Progressive Multiple Sclerosis: A Feasibility and Efficacy Pilot Randomised Controlled Trial

A great proportion of People with Multiple Sclerosis (PwMS) suffers from Cognitive Impairment (CI), which greatly diminishes the quality of life of those affected. Pharmacological treatments for CI in PwMS showed limited efficacy, and behaviourally-based interventions still remain the preferred care option. These typically involve in-clinic repeated one-on-one sessions with a therapist for a set period of time. This has been seen to be both costly and unfeasible for some PwMS. Telerehabilitat...

FUTURE-MAKER-GENERATIONS. CRITICAL PHENOMENOLOGY AND TRANSGENERATIVE SOCIAL ONTOLOGY

This thesis introduces the concept of Future-Maker Generations (FMGs), a novel form of plural subject described as an ethical and political community, globally disseminated and axiologically oriented towards the defence of plurality of all forms of life. The thesis aims to describe and analyse the emerging of FMGs from Future-Maker Personalities (FMPs), individuals united by a shared set of values oriented towards human plurality, global solidarity, human rights, and environmental protection....

LNA-ASO based therapy for the treatment of SARS-CoV-2 infection in pre-clinicals models

The COVID-19 crisis and the development of the first approved mRNA vaccine have highlighted the potential of RNA-based therapeutic strategies. Mutated variant strains of SARS-CoV-2 that evade immunity to previous infection or vaccination are continuously emerging, resulting in new outbreaks. Thus, there is a clear and urgent need for alternative approaches that are active against multiple variants of concern. Antisense oligonucleotides (ASOs) represent a new and promising class of RNA-targete...

Pregnancy during a pandemic: a deep phenotyping approach exploring the role of inflammation on postpartum cognitive decline and depression.

Peripartum depression (PPD) results in physical, emotional, and behavioral changes during pregnancy and postpartum that occur in roughly 20% of women, yet COVID-19 may have increased the prevalence of PPD. Furthermore, during this period, women may be vulnerable to the development of cognitive deficits. The biological causes of PPD and cognitive decline are still unclear. These issues may arise due to brain structural and functional alterations; however, results are inconclusive. Moreover, dy...

FUNCTIONAL AND STRUCTURAL MRI CORRELATES OF COGNITIVE DYSFUNCTION IN PEDIATRIC MS AND A COMPARISON OF COGNITIVE RESILIENCE WITH ADULT-ONSET MS

During my PhD, I focused on the study of the MRI substrates of cognition in pediatric-onset (PO) multiple sclerosis (MS) patients and on the validation of a novel paper-pencil cognitive test, the Consecutive-letter Substitution Test (CST), to assess information processing speed (IPS). By applying unsupervised machine learning, we identified three cognitive phenotypes in pediatric MS patients: normal functioning, mild verbal memory and semantic fluency deficits, and global impairment, each as...

Trust, Science and Disinformation

In this dissertation, my aim is to analyse the reasons and causes behind the spread of disinformation. In particular, my main interest is in what I will refer to as “scientific disinformation”, namely the kind of disinformation that regards scientific issues and topics, with a particular focus on climate change. The thesis is divided into five chapters, each with a specific purpose. The first chapter is dedicated to the definition of disinformation. I review the different definitions of disin...

Scopri
Istituto
  • Libera Università Vita-Salute San...285
Data di pubblicazione
  • 2020 - 2025200
  • 2010 - 201944
  • 2004 - 200941
Settore disciplinare
  • Settore BIO/11 - Biologia Molecolare31
  • Settore MED/26 - Neurologia21
  • Settore BIO/13 - Biologia Applicata20
  • Settore MED/04 - Patologia Generale20
  • Settore M-PSI/02 - Psicobiologia ...8
  • Settore MED/25 - Psichiatria7
  • Settore M-FIL/01 - Filosofia Teor...5
  • Settore M-FIL/03 - Filosofia Morale4
  • Settore M-FIL/05 - Filosofia e Te...4
  • Settore MED/15 - Malattie del Sangue4
Accesso al fulltext
  • open158
  • internalNetwork68
  • embargoed36
  • no fulltext10
  • mixed7
  • reserved6