Libera Università Vita-Salute San Raffaele di Milano

Libera Università Vita-Salute San Raffaele di Milano: [655] Istituto

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Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 221 a 240 di 655

Continuous recording of overt and covert visuospatial attention movements to visible and imagined targets by means of steady-state visual evoked potentials (SSVEPs)

2016

Targeting the monocyte/macrophage lineage as a novel therapeutic strategy for chronic lymphocytic leukemia

2016

Human embryonic stem (ES) cell-derived neural crest progenitor cells novel role of Sox2 in peripheral neurogenesis

2011

Unstable maternal environment, separation anxiety and heightened CO₂ sensitivity induced by gene-by-environment interplay dottorato di ricerca in psicopatologia dello sviluppo

2010

Dissection of Ras-ERK activity of L-Dopa induced dyskinesia in distinct subsets of striatal neurons and preclinical validation of a potential therapy

2014

Oxidative stress protection in proinflammatory-activated astrocytes from in vitro to in vivo

2012

EGFR expression identifies functionally distinct subpopulations of tumor-initiating cells in human glioblastoma multiforme and it is required for gliomagenesis degree of doctor in philosophy cellular and molecular biology, ciclo 23.

2011

In vitro disease modelling of the CDKL5 dependent atypical Rett syndrome

2013

Trusting what you're told, trusting what you're promised children's selective trust in promises

2017

Design and characterization of a new NGR-based tumor penetrating peptide

2011

MiR-511-3p modulates the protumoral properties of tumor associated macrophages

2012

The involvement of microRNAs in muscular dystrophies

2012

Anti aldolase A antibodies in patients with atypical movement disorders

2011

Molecular dissection of neutralizing human anti-hcv antibodies and structural definition of targeted epitopes

2011

Mapping progressive neurodegeneration and dysfunction in amyotrophic lateral sclerosis (ALS)

2017

Il pensiero morale di Lorenzo Valla

2018

The neuroprotective effects on grey matter volumes in aging bilingual populations

2017

HCV replication in gastrointestinal mucosa potenzial extra-hepatic viral reservoir and possible role in HCV infection recurrence after liver transplantation

2014

Novel extrinsic signals that control myelin or axonal domains formation in the nervous system

2015

What is it like to be a Bach? esperienza musicale e contenuto non-concettuale

2015

Istituto	Anno di pubblicazione	Titolo	Autore
Libera Università Vita-Salute San Raffaele di Milano	2016	Continuous recording of overt and covert visuospatial attention movements to visible and imagined targets by means of steady-state visual evoked potentials (SSVEPs)	-
Libera Università Vita-Salute San Raffaele di Milano	2016	Targeting the monocyte/macrophage lineage as a novel therapeutic strategy for chronic lymphocytic leukemia	-
Libera Università Vita-Salute San Raffaele di Milano	2011	Human embryonic stem (ES) cell-derived neural crest progenitor cells novel role of Sox2 in peripheral neurogenesis	-
Libera Università Vita-Salute San Raffaele di Milano	2010	Unstable maternal environment, separation anxiety and heightened CO₂ sensitivity induced by gene-by-environment interplay dottorato di ricerca in psicopatologia dello sviluppo	-
Libera Università Vita-Salute San Raffaele di Milano	2014	Dissection of Ras-ERK activity of L-Dopa induced dyskinesia in distinct subsets of striatal neurons and preclinical validation of a potential therapy	-
Libera Università Vita-Salute San Raffaele di Milano	2012	Oxidative stress protection in proinflammatory-activated astrocytes from in vitro to in vivo	-
Libera Università Vita-Salute San Raffaele di Milano	2011	EGFR expression identifies functionally distinct subpopulations of tumor-initiating cells in human glioblastoma multiforme and it is required for gliomagenesis degree of doctor in philosophy cellular and molecular biology, ciclo 23.	-
Libera Università Vita-Salute San Raffaele di Milano	2013	In vitro disease modelling of the CDKL5 dependent atypical Rett syndrome	-
Libera Università Vita-Salute San Raffaele di Milano	2017	Trusting what you're told, trusting what you're promised children's selective trust in promises	-
Libera Università Vita-Salute San Raffaele di Milano	2011	Design and characterization of a new NGR-based tumor penetrating peptide	-
Libera Università Vita-Salute San Raffaele di Milano	2012	MiR-511-3p modulates the protumoral properties of tumor associated macrophages	-
Libera Università Vita-Salute San Raffaele di Milano	2012	The involvement of microRNAs in muscular dystrophies	-
Libera Università Vita-Salute San Raffaele di Milano	2011	Anti aldolase A antibodies in patients with atypical movement disorders	-
Libera Università Vita-Salute San Raffaele di Milano	2011	Molecular dissection of neutralizing human anti-hcv antibodies and structural definition of targeted epitopes	-
Libera Università Vita-Salute San Raffaele di Milano	2017	Mapping progressive neurodegeneration and dysfunction in amyotrophic lateral sclerosis (ALS)	-
Libera Università Vita-Salute San Raffaele di Milano	2018	Il pensiero morale di Lorenzo Valla	-
Libera Università Vita-Salute San Raffaele di Milano	2017	The neuroprotective effects on grey matter volumes in aging bilingual populations	-
Libera Università Vita-Salute San Raffaele di Milano	2014	HCV replication in gastrointestinal mucosa potenzial extra-hepatic viral reservoir and possible role in HCV infection recurrence after liver transplantation	-
Libera Università Vita-Salute San Raffaele di Milano	2015	Novel extrinsic signals that control myelin or axonal domains formation in the nervous system	-
Libera Università Vita-Salute San Raffaele di Milano	2015	What is it like to be a Bach? esperienza musicale e contenuto non-concettuale	-

Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 221 a 240 di 655

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Prodotti recenti

Proliferative stress and DNA damage response pathways in hematopoietic stem cell gene therapy and clonal hematopoiesis

Gene editing (GE) of hematopoietic stem and progenitor cells (HSPCs) holds significant therapeutic promise but remains constrained by genotoxic risks associated with DNA double-strand breaks, donor template delivery, and proliferation-induced stress during ex vivo manipulation. Ex vivo culture is indispensable to achieve efficient homology-directed repair (HDR), yet comes at the cost of inducing cellular stress and compromising HSPC fitness. Here, we identify p38 MAPK signaling as a central r...

Studying human Hematopoietic Stem/Progenitor Cells Trafficking in vivo

Hematopoiesis, Gene Therapy

Unraveling the role of the alarmin HMGB1 in the ageing process

High Mobility Group Box 1 (HMGB1) is a nuclear protein that, in physiological conditions, is predominantly localized in the nucleus. Upon cellular stress, it can translocate to the cytosol and can be released extracellularly, where it regulates tissue regeneration and inflammatory responses in a redox-state-dependent manner. HMGB1 bioactivities has been associated with several hallmarks of aging, and HMGB1 has been recently proposed as a biomarker of frailty. Here we hypothesized that aging p...

Unravelling the role of Integrated Stress Response signalling in metastatic Breast Cancer bioenergetics

The Integrated Stress Response (ISR) is an evolutionarily conserved adaptive pathway that mediates translation reprogramming in response to microenvironmental stress, often hijacked by cancer cells to promote metastasis. To reveal novel targetable vulnerabilities in Triple-negative Breast Cancer (TNBC), the most aggressive breast cancer subtype, characterized by high metastatic propensity and limited therapeutic options, here we elucidate the mechanisms by which ISR accommodates the energy de...

AI-HOPE Lung cancer: building a predictive tool for metastatic lung cancer

Metastatic non-small-cell lung cancer (NSCLC) represents a heterogeneous disease with markedly variable outcomes, and reliable prognostic and predictive tools are urgently needed, particularly in the real-world setting. The AI-HOPE study was designed as an ambispective, multicentre project to collect real-world data and develop machine-learning models capable of predicting clinical endpoints in patients with metastatic NSCLC receiving first-line immunotherapy with or without chemotherapy. In ...

Leveraging real-world data with machine learning to disentangle the complexity of multimorbid internal medicine patients

The application of machine learning to healthcare real-world data is emerging as a complementary approach to clinical trials for enabling data-driven decision-making in the evolving population of complex patients managed in the internal medicine setting. To fully realise this potential, significant challenges remain, including data availability and quality limitations and the absence of standardized protocols for model development. In this thesis, we explore how to build an end-to-end machine...

Kant on Analogy: The Problem of Predicating the Noumenon in the Precritical Works

The dissertation aims to analyze Kant’s use of the concept of analogy in his precritical writings, while also reconstructing the historical development of the notion of analogy in order to provide a more accurate historical contextualization of Kant’s works. In doing so, it seeks to demonstrate that the characteristically critical concepts of regulative and constitutive knowledge can be traced back to the precritical period, specifically to Kant’s use of analogy as a means of addressing the p...

CLIMATE CHANGE AND MOTIVATION: VALUES, KNOWLEDGE, EDUCATION

sostenibilità, etica ambientale, filosofia morale, responsabilità individuale e collettiva, cambiamento climatico, educazione ambientale, educazione alla sostenibilità, comunicazione ambientale

The role of MFSD2A in the resolution of colorectal cancer-promoting inflammation: implications for innovative therapies

The intrinsic connection between inflammation and tumor promotion is well established and represents a key pathogenic factor in colorectal cancer (CRC). Therefore, reducing pro-inflammatory milieu without impairing physiological immune defenses or anti-tumor immunity becomes a desirable therapeutic strategy. Endogenous specialized pro-resolving mediators (SPMs), primarily derived from the ω-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid, actively promote th...

Studio degli effetti non cellulo-autonomi della mutazione p.A382T di TDP-43 nelle cellule di Schwann tramite l'utilizzo di un modello in vivo e di un modello in vitro

Il tratto neuropatologico distintivo della sclerosi laterale amiotrofica (SLA), una malattia neurodegenerativa caratterizzata dal coinvolgimento di primo e secondo motoneurone, è la mislocalizzazione, aggregazione e fosforilazione della proteina TDP-43, nota come patologia da TDP-43, nei tessuti affetti. In alcuni casi, nei pazienti con SLA vengono identificate mutazioni in TDP-43, suggerendo che questa proteina abbia un ruolo causale nella malattia. La variante missenso p.A382T è la più comu...

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