UNITesi

Libera Università Vita-Salute San Raffaele di Milano: [285] Istituto

Sfoglia
Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 241 a 260 di 285
Istituto Anno di pubblicazione Titolo Autore file(s)
Libera Università Vita-Salute San Raffaele di Milano 2022 Dissecting the oncogenic mechanism of DUX4-IGH in acute lymphoblastic leukemia -
Libera Università Vita-Salute San Raffaele di Milano 2023 STRUCTURAL AND FUNCTIONAL BRAIN ALTERATIONS IN PARKINSON’S DISEASE AND POSSIBLE NON-PHARMACOLOGICAL APPROACHES -
Libera Università Vita-Salute San Raffaele di Milano 2022 Precise characterization of hemogenic endothelial cells during human hematopoietic development -
Libera Università Vita-Salute San Raffaele di Milano 2023 Improving fertility preservation strategies in women with cancer: development of a murine model of gonadotoxicity and clinical prognostic signatures of gonadal damage -
Libera Università Vita-Salute San Raffaele di Milano 2023 MICRO-MECHANICAL FINGERPRINTS OF BLADDER IN HEALTH AND DISEASE -
Libera Università Vita-Salute San Raffaele di Milano 2024 ELUCIDATING THE ROLE OF PROMYELOCYTIC LEUKEMIA GENE IN CLEAR CELL RENAL CELL CARCINOMA -
Libera Università Vita-Salute San Raffaele di Milano 2022 Cancer-Glia interaction in perineural invasion in pancreatic cancer: identification of FGF-BP1 as a molecular target -
Libera Università Vita-Salute San Raffaele di Milano 2022 Dissecting the functions of promyelocytic leukemia gene in renal cancer -
Libera Università Vita-Salute San Raffaele di Milano 2023 A molecular and environmental approach to dissect disease heterogeneity in multiple sclerosis -
Libera Università Vita-Salute San Raffaele di Milano 2022 DISSECTING THE ROLE OF CLPP IN MULTIPLE MYELOMA -
Libera Università Vita-Salute San Raffaele di Milano 2022 Combinatorial gene therapy for epilepsy -
Libera Università Vita-Salute San Raffaele di Milano 2023 THE ROLE OF THE POLYCYSTINS AND CILIA IN REGULATION OF MITOCHONDRIA AND METABOLISM -
Libera Università Vita-Salute San Raffaele di Milano 2022 Dissecting the mechanisms of transcriptional regulation by PML in triple-negative breast cancer -
Libera Università Vita-Salute San Raffaele di Milano 2023 N-glycosylation inhibition hinders immunosuppressive tumor microenvironment cells improving CAR T cell efficacy -
Libera Università Vita-Salute San Raffaele di Milano 2023 Validating advanced MRI features as surrogate biomarkers of the molecular subgroups of glioblastoma by exploiting patient-specific cancer stem cell (CSC)-based animal models. -
Libera Università Vita-Salute San Raffaele di Milano 2023 TARGETING TRANSFERRIN RECEPTOR 2: A NOVEL ERYTHROPOIESIS STIMULATING APPROACH IN ANEMIA OF CHRONIC KIDNEY DISEASE AND OTHER ANEMIAS -
Libera Università Vita-Salute San Raffaele di Milano 2024 Tolerogenic IL-10-producing Dendritic Cells directly and indirectly regulate Ag-specific B cell responses. -
Libera Università Vita-Salute San Raffaele di Milano 2023 Intrinsic cellular cues influencing astrocyte-to- neuron conversion. -
Libera Università Vita-Salute San Raffaele di Milano 2021 Microbiome and bladder cancer -
Libera Università Vita-Salute San Raffaele di Milano 2023 Dissecting the non-cell autonomous effects of oncogene activation on hematopoiesis -
Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 241 a 260 di 285
Legenda icone

  •  file ad accesso aperto
  •  file disponibili sulla rete interna
  •  file disponibili agli utenti autorizzati
  •  file disponibili solo agli amministratori
  •  file sotto embargo
  •  nessun file disponibile

Prodotti recenti

Degenerazione assonale nelle neuropatie periferiche: dai meccanismi molecolari all’approccio terapeutico

La malattia di Charcot-Marie-Tooth (CMT) è la neuropatia periferica ereditaria più frequentemente osservata, con una prevalenza di circa 1 su 2.500 persone. È un gruppo di patologie geneticamente eterogeneo, con mutazioni in oltre 100 geni, che colpisce sia i nervi motori sia quelli sensoriali. La mutazione T124M nel gene MPZ dà origine alla CMT2J, un sottotipo particolarmente interessante con una particolare prevalenza nell’Italia settentrionale. Sebbene MPZ sia una proteina esclusivamente e...

Lo studio dell'età cellulare sulla funzione delle β cellule derivate da iPSC

Una fonte affidabile di β cellule è essenziale per l'avanzamento della terapia cellulare nel diabete di tipo 1. Le cellule staminali pluripotenti indotte possono differenziarsi in β cellule produttrici di insulina, imitando efficacemente lo sviluppo pancreatico in vitro. Mentre la senescenza cellulare supporta la formazione di β cellule durante l'embriogenesi, la loro senescenza cellulare legata all'invecchiamento compromette il rilevamento del glucosio e la secrezione di insulina. Tuttavia, ...

Imaging, genetic and biomarkers characterization of arrhythmic mitral valve prolapse

Association between genotype and phenotype in mitral valve prolapse patients and their impact on arrhythmic outcomes

Digital Cognitive Assessment and its Relationship with Disability in Multiple Sclerosis

Introduction. Cognitive impairment is common in people with MS (pwMS) and significantly impacts functional independence. The Symbol-Digit Modalities Test (SDMT) is widely used to assess cognitive deficits in pwMS. Electronic adaptations of the SDMT (eSDMT) can enable remote monitoring and capture more detailed performance metrics, compared to pen-and-paper tests. This study details the development and validation of a custom-made eSDMT intended to enable long-term remote cognitive monitoring o...

At-home extension of computerised cognitive rehabilitation in People with Progressive Multiple Sclerosis: A Feasibility and Efficacy Pilot Randomised Controlled Trial

A great proportion of People with Multiple Sclerosis (PwMS) suffers from Cognitive Impairment (CI), which greatly diminishes the quality of life of those affected. Pharmacological treatments for CI in PwMS showed limited efficacy, and behaviourally-based interventions still remain the preferred care option. These typically involve in-clinic repeated one-on-one sessions with a therapist for a set period of time. This has been seen to be both costly and unfeasible for some PwMS. Telerehabilitat...

FUTURE-MAKER-GENERATIONS. CRITICAL PHENOMENOLOGY AND TRANSGENERATIVE SOCIAL ONTOLOGY

This thesis introduces the concept of Future-Maker Generations (FMGs), a novel form of plural subject described as an ethical and political community, globally disseminated and axiologically oriented towards the defence of plurality of all forms of life. The thesis aims to describe and analyse the emerging of FMGs from Future-Maker Personalities (FMPs), individuals united by a shared set of values oriented towards human plurality, global solidarity, human rights, and environmental protection....

LNA-ASO based therapy for the treatment of SARS-CoV-2 infection in pre-clinicals models

The COVID-19 crisis and the development of the first approved mRNA vaccine have highlighted the potential of RNA-based therapeutic strategies. Mutated variant strains of SARS-CoV-2 that evade immunity to previous infection or vaccination are continuously emerging, resulting in new outbreaks. Thus, there is a clear and urgent need for alternative approaches that are active against multiple variants of concern. Antisense oligonucleotides (ASOs) represent a new and promising class of RNA-targete...

Pregnancy during a pandemic: a deep phenotyping approach exploring the role of inflammation on postpartum cognitive decline and depression.

Peripartum depression (PPD) results in physical, emotional, and behavioral changes during pregnancy and postpartum that occur in roughly 20% of women, yet COVID-19 may have increased the prevalence of PPD. Furthermore, during this period, women may be vulnerable to the development of cognitive deficits. The biological causes of PPD and cognitive decline are still unclear. These issues may arise due to brain structural and functional alterations; however, results are inconclusive. Moreover, dy...

FUNCTIONAL AND STRUCTURAL MRI CORRELATES OF COGNITIVE DYSFUNCTION IN PEDIATRIC MS AND A COMPARISON OF COGNITIVE RESILIENCE WITH ADULT-ONSET MS

During my PhD, I focused on the study of the MRI substrates of cognition in pediatric-onset (PO) multiple sclerosis (MS) patients and on the validation of a novel paper-pencil cognitive test, the Consecutive-letter Substitution Test (CST), to assess information processing speed (IPS). By applying unsupervised machine learning, we identified three cognitive phenotypes in pediatric MS patients: normal functioning, mild verbal memory and semantic fluency deficits, and global impairment, each as...

Trust, Science and Disinformation

In this dissertation, my aim is to analyse the reasons and causes behind the spread of disinformation. In particular, my main interest is in what I will refer to as “scientific disinformation”, namely the kind of disinformation that regards scientific issues and topics, with a particular focus on climate change. The thesis is divided into five chapters, each with a specific purpose. The first chapter is dedicated to the definition of disinformation. I review the different definitions of disin...

Scopri
Istituto
  • Libera Università Vita-Salute San...285
Data di pubblicazione
  • 2020 - 2025200
  • 2010 - 201944
  • 2004 - 200941
Settore disciplinare
  • Settore BIO/11 - Biologia Molecolare31
  • Settore MED/26 - Neurologia21
  • Settore BIO/13 - Biologia Applicata20
  • Settore MED/04 - Patologia Generale20
  • Settore M-PSI/02 - Psicobiologia ...8
  • Settore MED/25 - Psichiatria7
  • Settore M-FIL/01 - Filosofia Teor...5
  • Settore M-FIL/03 - Filosofia Morale4
  • Settore M-FIL/05 - Filosofia e Te...4
  • Settore MED/15 - Malattie del Sangue4
Accesso al fulltext
  • open158
  • internalNetwork68
  • embargoed36
  • no fulltext10
  • mixed7
  • reserved6