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Libera Università Vita-Salute San Raffaele di Milano: [651] Istituto

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Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 261 a 280 di 651
Istituto Anno di pubblicazione Titolo Autore file(s)
Libera Università Vita-Salute San Raffaele di Milano 2012 Differential usage of regulatory elements in human neural differentiation a genome-wide analysis -
Libera Università Vita-Salute San Raffaele di Milano 2013 Identification of the protease mediating uromodulin urinary release and insight into the mechanism of uromodulin polymerization -
Libera Università Vita-Salute San Raffaele di Milano 2012 A novel immunotherapy approach for the targeting of acute myeloid leukaemia by the use of chimeric antigen receptors (CARs) -
Libera Università Vita-Salute San Raffaele di Milano 2012 Dissection of cellular and molecular mechanisms underlying B-cell and platelet defects in Wiskott-Aldrich syndrome before and after gene therapy -
Libera Università Vita-Salute San Raffaele di Milano 2012 FSHD muscular dystrophy region gene 1 binds SUV4-20H1 histone methyltransferase and impairs myogenesis -
Libera Università Vita-Salute San Raffaele di Milano 2011 TSC/mTOR signalling controls thymocyte development and proliferation/differentiation of T lymphocytes and nerve cells -
Libera Università Vita-Salute San Raffaele di Milano 2011 Evaluation of dendritic cell functionality in gene therapy was-/- mice and characterization of novel dendritic cell-mediated defects in was-/- mice Ph. D. program in molecular and cellular biology -
Libera Università Vita-Salute San Raffaele di Milano 2011 Characterization of microRNAs expression profiles from peripheral blood cells in patients affected by multiple sclerosis -
Libera Università Vita-Salute San Raffaele di Milano 2011 Development and characterization of new antiangiogenic treatments targeting tumour vessels and pro-angiogenic bone marrow-derived cells -
Libera Università Vita-Salute San Raffaele di Milano 2012 Development and immunological evaluation of particulate antigenic approaches to HIV -
Libera Università Vita-Salute San Raffaele di Milano 2015 Mapping genes and pathways changed following ex vivo engineering of hematopoietic stem cells -
Libera Università Vita-Salute San Raffaele di Milano 2015 Role of allelic imbalance in predicting the risk of hepatocellular carcinoma (HCC) recurrence after liver transplantation -
Libera Università Vita-Salute San Raffaele di Milano 2015 Neuronal ADAM17 promotes oligodendrocyte differentiation and central nervous system myelination -
Libera Università Vita-Salute San Raffaele di Milano 2011 Viral characterization and humoral immune response in the setting of primary HIV-1 infection -
Libera Università Vita-Salute San Raffaele di Milano 2015 MR markers of disease pathophysiology in atypical forms of Alzheimerʼs disease and other dementias -
Libera Università Vita-Salute San Raffaele di Milano 2013 The transcription factor Nfix regulates the proper timing of muscle regeneration and the progression of muscular dystrophy -
Libera Università Vita-Salute San Raffaele di Milano 2011 Cellular and molecular mechanisms of bace1 translational control in neurons and astrocytes -
Libera Università Vita-Salute San Raffaele di Milano 2012 Polycystin-1 binds the Par3/aPKC complex to control polarized cell migration and renal tubular morphogenesis -
Libera Università Vita-Salute San Raffaele di Milano 2011 ERK1 MAP kinase antagonizes ERK2 dependent signaling in the control of the neuronal cell survival and striatal neurodegeneration -
Libera Università Vita-Salute San Raffaele di Milano 2011 Functional dissection of protective activity of human chimeric IgG monoclonal antibodies to meningococcal factor H binding protein -
Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 261 a 280 di 651
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AI-HOPE Lung cancer: building a predictive tool for metastatic lung cancer

Metastatic non-small-cell lung cancer (NSCLC) represents a heterogeneous disease with markedly variable outcomes, and reliable prognostic and predictive tools are urgently needed, particularly in the real-world setting. The AI-HOPE study was designed as an ambispective, multicentre project to collect real-world data and develop machine-learning models capable of predicting clinical endpoints in patients with metastatic NSCLC receiving first-line immunotherapy with or without chemotherapy. In ...

Leveraging real-world data with machine learning to disentangle the complexity of multimorbid internal medicine patients

The application of machine learning to healthcare real-world data is emerging as a complementary approach to clinical trials for enabling data-driven decision-making in the evolving population of complex patients managed in the internal medicine setting. To fully realise this potential, significant challenges remain, including data availability and quality limitations and the absence of standardized protocols for model development. In this thesis, we explore how to build an end-to-end machine...

Kant on Analogy: The Problem of Predicating the Noumenon in the Precritical Works

The dissertation aims to analyze Kant’s use of the concept of analogy in his precritical writings, while also reconstructing the historical development of the notion of analogy in order to provide a more accurate historical contextualization of Kant’s works. In doing so, it seeks to demonstrate that the characteristically critical concepts of regulative and constitutive knowledge can be traced back to the precritical period, specifically to Kant’s use of analogy as a means of addressing the p...

CLIMATE CHANGE AND MOTIVATION: VALUES, KNOWLEDGE, EDUCATION

sostenibilità, etica ambientale, filosofia morale, responsabilità individuale e collettiva, cambiamento climatico, educazione ambientale, educazione alla sostenibilità, comunicazione ambientale

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The intrinsic connection between inflammation and tumor promotion is well established and represents a key pathogenic factor in colorectal cancer (CRC). Therefore, reducing pro-inflammatory milieu without impairing physiological immune defenses or anti-tumor immunity becomes a desirable therapeutic strategy. Endogenous specialized pro-resolving mediators (SPMs), primarily derived from the ω-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid, actively promote th...

Studio degli effetti non cellulo-autonomi della mutazione p.A382T di TDP-43 nelle cellule di Schwann tramite l'utilizzo di un modello in vivo e di un modello in vitro

Il tratto neuropatologico distintivo della sclerosi laterale amiotrofica (SLA), una malattia neurodegenerativa caratterizzata dal coinvolgimento di primo e secondo motoneurone, è la mislocalizzazione, aggregazione e fosforilazione della proteina TDP-43, nota come patologia da TDP-43, nei tessuti affetti. In alcuni casi, nei pazienti con SLA vengono identificate mutazioni in TDP-43, suggerendo che questa proteina abbia un ruolo causale nella malattia. La variante missenso p.A382T è la più comu...

Artificial intelligence of imaging and clinical neurological data for predictive, preventive and personalized medicine for Gliomas

Diffuse gliomas represent the most common malignant primary brain tumors in adults and are now classified according to integrated histopathological and molecular criteria as proposed by the latest WHO CNS5 guidelines. Among the defining molecular alterations, mutations in isocitrate dehydrogenase (IDH) genes have emerged as pivotal for prognosis and therapeutic stratification with substantial implications for clinical outcome. However, current determination of IDH status relies primarily on i...

IN DEPTH CHARACTERIZATION OF MONOCYTE-B CELL INTERACTIONS IN INFECTION AND CANCER

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Role of adenosine deaminase 2 in hematopoiesis regulation

Il deficit di adenosina deaminasi 2 (DADA2) è una rara malattia autosomica recessiva caratterizzata da infiammazione sistemica, disregolazione immunitaria e insufficienza midollare. Sebbene la terapia anti-TNF controlli la vasculite, non ripristina l’ematopoiesi, né previene la progressione verso l’insufficienza midollare, lasciando irrisolto come la perdita di ADA2 comprometta la funzione delle cellule staminali e progenitrici ematopoietiche (HSPC). Questa tesi caratterizza le HSPC dei pazie...

Scopri
Istituto
  • Libera Università Vita-Salute San...643
Data di pubblicazione
  • 2020 - 2026254
  • 2010 - 2019355
  • 2001 - 200942
Settore disciplinare
  • Settore BIO/11 - Biologia Molecolare81
  • Settore BIO/13 - Biologia Applicata71
  • Settore MED/26 - Neurologia70
  • Settore MED/04 - Patologia Generale62
  • Settore M-FIL/01 - Filosofia Teor...18
  • Settore MED/15 - Malattie del Sangue18
  • Settore M-PSI/02 - Psicobiologia ...17
  • Settore MED/25 - Psichiatria14
  • Settore M-FIL/03 - Filosofia Morale12
  • Settore M-FIL/06 - Storia della F...12
Accesso al fulltext
  • no fulltext318
  • open220
  • internalNetwork74
  • embargoed26
  • mixed5