Libera Università Vita-Salute San Raffaele di Milano

Libera Università Vita-Salute San Raffaele di Milano: [661] Istituto

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Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 261 a 280 di 661

Microglia gene expression profile throught life and under neuroinflammatory conditions insights into their plasticity

2015

Regulation of diverse cellular functions through AQP8-mediated hydrogen peroxide transport

2014

Language, pragmatics and cognition in schizophrenia

2014

Diet, gut inflammation and the microbiota preventing autoimmune diabetes in the gut mucosa

2014

Pancretic cancer and diabetes preclinical and clinical investigation for biomarker discovery

2016

Adoptive T cell therapy dual tumor/tumor-stroma targeting to ameliorate efficacy

2013

The role of subthalamic nucleus in moral conflict a neurophysiological and stimulation study

2014

Ad hoc modulation of extracellular matrix by colorectal carcinoma favours cell invasion and proliferation

2013

Role of micrornas in brain development evidence for the involvement of the serine protease HTRA1

2012

Plasma cells require autophagy for sustainable Ig production

2012

Differential usage of regulatory elements in human neural differentiation a genome-wide analysis

2012

Identification of the protease mediating uromodulin urinary release and insight into the mechanism of uromodulin polymerization

2013

A novel immunotherapy approach for the targeting of acute myeloid leukaemia by the use of chimeric antigen receptors (CARs)

2012

Dissection of cellular and molecular mechanisms underlying B-cell and platelet defects in Wiskott-Aldrich syndrome before and after gene therapy

2012

FSHD muscular dystrophy region gene 1 binds SUV4-20H1 histone methyltransferase and impairs myogenesis

2012

TSC/mTOR signalling controls thymocyte development and proliferation/differentiation of T lymphocytes and nerve cells

2011

Evaluation of dendritic cell functionality in gene therapy was-/- mice and characterization of novel dendritic cell-mediated defects in was-/- mice Ph. D. program in molecular and cellular biology

2011

Characterization of microRNAs expression profiles from peripheral blood cells in patients affected by multiple sclerosis

2011

Development and characterization of new antiangiogenic treatments targeting tumour vessels and pro-angiogenic bone marrow-derived cells

2011

Development and immunological evaluation of particulate antigenic approaches to HIV

2012

Istituto	Anno di pubblicazione	Titolo	Autore
Libera Università Vita-Salute San Raffaele di Milano	2015	Microglia gene expression profile throught life and under neuroinflammatory conditions insights into their plasticity	-
Libera Università Vita-Salute San Raffaele di Milano	2014	Regulation of diverse cellular functions through AQP8-mediated hydrogen peroxide transport	-
Libera Università Vita-Salute San Raffaele di Milano	2014	Language, pragmatics and cognition in schizophrenia	-
Libera Università Vita-Salute San Raffaele di Milano	2014	Diet, gut inflammation and the microbiota preventing autoimmune diabetes in the gut mucosa	-
Libera Università Vita-Salute San Raffaele di Milano	2016	Pancretic cancer and diabetes preclinical and clinical investigation for biomarker discovery	-
Libera Università Vita-Salute San Raffaele di Milano	2013	Adoptive T cell therapy dual tumor/tumor-stroma targeting to ameliorate efficacy	-
Libera Università Vita-Salute San Raffaele di Milano	2014	The role of subthalamic nucleus in moral conflict a neurophysiological and stimulation study	-
Libera Università Vita-Salute San Raffaele di Milano	2013	Ad hoc modulation of extracellular matrix by colorectal carcinoma favours cell invasion and proliferation	-
Libera Università Vita-Salute San Raffaele di Milano	2012	Role of micrornas in brain development evidence for the involvement of the serine protease HTRA1	-
Libera Università Vita-Salute San Raffaele di Milano	2012	Plasma cells require autophagy for sustainable Ig production	-
Libera Università Vita-Salute San Raffaele di Milano	2012	Differential usage of regulatory elements in human neural differentiation a genome-wide analysis	-
Libera Università Vita-Salute San Raffaele di Milano	2013	Identification of the protease mediating uromodulin urinary release and insight into the mechanism of uromodulin polymerization	-
Libera Università Vita-Salute San Raffaele di Milano	2012	A novel immunotherapy approach for the targeting of acute myeloid leukaemia by the use of chimeric antigen receptors (CARs)	-
Libera Università Vita-Salute San Raffaele di Milano	2012	Dissection of cellular and molecular mechanisms underlying B-cell and platelet defects in Wiskott-Aldrich syndrome before and after gene therapy	-
Libera Università Vita-Salute San Raffaele di Milano	2012	FSHD muscular dystrophy region gene 1 binds SUV4-20H1 histone methyltransferase and impairs myogenesis	-
Libera Università Vita-Salute San Raffaele di Milano	2011	TSC/mTOR signalling controls thymocyte development and proliferation/differentiation of T lymphocytes and nerve cells	-
Libera Università Vita-Salute San Raffaele di Milano	2011	Evaluation of dendritic cell functionality in gene therapy was-/- mice and characterization of novel dendritic cell-mediated defects in was-/- mice Ph. D. program in molecular and cellular biology	-
Libera Università Vita-Salute San Raffaele di Milano	2011	Characterization of microRNAs expression profiles from peripheral blood cells in patients affected by multiple sclerosis	-
Libera Università Vita-Salute San Raffaele di Milano	2011	Development and characterization of new antiangiogenic treatments targeting tumour vessels and pro-angiogenic bone marrow-derived cells	-
Libera Università Vita-Salute San Raffaele di Milano	2012	Development and immunological evaluation of particulate antigenic approaches to HIV	-

Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 261 a 280 di 661

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Studying immunometabolic alterations in age-related diseases

The tricarboxylic acid (TCA) cycle is a core metabolic pathway for the generation of mitochondrial ATP and key anabolic intermediates in cells. Succinate dehydrogenase (SDH), the enzymatic complex that catalyzes the oxidation of succinate to fumarate in the TCA cycle, stands as the first mitochondrial enzyme found mutated in cancer. Loss of SDH function disrupts the TCA cycle and triggers succinate accumulation in tumor cells. However, how tumors cope with a dysfunctional TCA cycle remains la...

VALIDATION OF ARTIFICIAL EPIGENETIC SILENCER TO REDUCE GLIOBLASTOMA IN IMMUNOCOMPETENT MOUSE MODEL

Glioblastoma (GBM) is the most aggressive primary brain tumor in adults and remains associated with extremely poor prognosis despite multimodal treatment, including surgery, radiotherapy, and chemotherapy. The limited efficacy of current therapies reflects key features of this malignancy, including marked inter- and intra-tumoral heterogeneity, highly infiltrative growth, and the strong influence of the tumor microenvironment on disease progression and therapeutic response. In particular, the...

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Svelare l’impatto del microbiota sulla fibrosi intestinale: nuove prospettive per la patogenesi e il trattamento delle complicanze associate al morbo di Crohn.

Complicanze fibrotiche della malattia di Crohn

Lo standard setting delle organizzazioni internazionali per la Pubblica Amministrazione nell'epoca della fine dell'ordine globale neoliberale

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REFORMING COMMUNICATION IN PUBLIC ADMINISTRATION: A RESEARCH ON INCLUSIVE LANGUAGE

Linguaggio inclusivo di genere

Proliferative stress and DNA damage response pathways in hematopoietic stem cell gene therapy and clonal hematopoiesis

Gene editing (GE) of hematopoietic stem and progenitor cells (HSPCs) holds significant therapeutic promise but remains constrained by genotoxic risks associated with DNA double-strand breaks, donor template delivery, and proliferation-induced stress during ex vivo manipulation. Ex vivo culture is indispensable to achieve efficient homology-directed repair (HDR), yet comes at the cost of inducing cellular stress and compromising HSPC fitness. Here, we identify p38 MAPK signaling as a central r...

Studying human Hematopoietic Stem/Progenitor Cells Trafficking in vivo

Hematopoiesis, Gene Therapy

Unraveling the role of the alarmin HMGB1 in the ageing process

High Mobility Group Box 1 (HMGB1) is a nuclear protein that, in physiological conditions, is predominantly localized in the nucleus. Upon cellular stress, it can translocate to the cytosol and can be released extracellularly, where it regulates tissue regeneration and inflammatory responses in a redox-state-dependent manner. HMGB1 bioactivities has been associated with several hallmarks of aging, and HMGB1 has been recently proposed as a biomarker of frailty. Here we hypothesized that aging p...

Unravelling the role of Integrated Stress Response signalling in metastatic Breast Cancer bioenergetics

The Integrated Stress Response (ISR) is an evolutionarily conserved adaptive pathway that mediates translation reprogramming in response to microenvironmental stress, often hijacked by cancer cells to promote metastasis. To reveal novel targetable vulnerabilities in Triple-negative Breast Cancer (TNBC), the most aggressive breast cancer subtype, characterized by high metastatic propensity and limited therapeutic options, here we elucidate the mechanisms by which ISR accommodates the energy de...

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