Metastatic non-small-cell lung cancer (NSCLC) represents a heterogeneous disease with markedly variable outcomes, and reliable prognostic and predictive tools are urgently needed, particularly in the real-world setting. The AI-HOPE study was designed as an ambispective, multicentre project to collect real-world data and develop machine-learning models capable of predicting clinical endpoints in patients with metastatic NSCLC receiving first-line immunotherapy with or without chemotherapy.
In ...
The application of machine learning to healthcare real-world data is emerging as a complementary approach to clinical trials for enabling data-driven decision-making in the evolving population of complex patients managed in the internal medicine setting. To fully realise this potential, significant challenges remain, including data availability and quality limitations and the absence of standardized protocols for model development. In this thesis, we explore how to build an end-to-end machine...
The dissertation aims to analyze Kant’s use of the concept of analogy in his precritical writings, while also reconstructing the historical development of the notion of analogy in order to provide a more accurate historical contextualization of Kant’s works. In doing so, it seeks to demonstrate that the characteristically critical concepts of regulative and constitutive knowledge can be traced back to the precritical period, specifically to Kant’s use of analogy as a means of addressing the p...
sostenibilità, etica ambientale, filosofia morale, responsabilità individuale e collettiva, cambiamento climatico, educazione ambientale, educazione alla sostenibilità, comunicazione ambientale
The intrinsic connection between inflammation and tumor promotion is well established and represents a key pathogenic factor in colorectal cancer (CRC). Therefore, reducing pro-inflammatory milieu without impairing physiological immune defenses or anti-tumor immunity becomes a desirable therapeutic strategy. Endogenous specialized pro-resolving mediators (SPMs), primarily derived from the ω-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid, actively promote th...
Il tratto neuropatologico distintivo della sclerosi laterale amiotrofica (SLA), una malattia neurodegenerativa caratterizzata dal coinvolgimento di primo e secondo motoneurone, è la mislocalizzazione, aggregazione e fosforilazione della proteina TDP-43, nota come patologia da TDP-43, nei tessuti affetti. In alcuni casi, nei pazienti con SLA vengono identificate mutazioni in TDP-43, suggerendo che questa proteina abbia un ruolo causale nella malattia. La variante missenso p.A382T è la più comu...
Diffuse gliomas represent the most common malignant primary brain tumors in adults
and are now classified according to integrated histopathological and molecular criteria as
proposed by the latest WHO CNS5 guidelines. Among the defining molecular alterations,
mutations in isocitrate dehydrogenase (IDH) genes have emerged as pivotal for prognosis
and therapeutic stratification with substantial implications for clinical outcome. However,
current determination of IDH status relies primarily on i...
B cells are central to adaptive immunity, but many viruses interfere with their
functions. For instance, our group previously described that, in the context of infection
with the poorly cytopathic Lymphocytic Choriomeningitis Virus (LCMV), monocytes
recruited to the draining lymph nodes (dLNs) mediate the killing of virus-specific B cells,
hindering the generation of neutralizing antibodies. This reveals an unexpected level of
monocyte-mediated regulation of humoral immunity, although the und...
Introduzione: La gastroparesi (GP) è un disturbo cronico della motilità gastrica, spesso sottodiagnosticato, con un impatto rilevante sulla qualità di vita. I meccanismi tissutali alla base della malattia sono ancora poco definiti. La G-POEM è una nuova opzione terapeutica endoscopica per la GP refrattaria, ma mancano predittori affidabili di risposta. Questo studio ha avuto l’obiettivo di caratterizzare i profili trascrittomici e metatrascrittomici gastrici in pazienti con GP idiopatica o di...
Il deficit di adenosina deaminasi 2 (DADA2) è una rara malattia autosomica recessiva caratterizzata da infiammazione sistemica, disregolazione immunitaria e insufficienza midollare. Sebbene la terapia anti-TNF controlli la vasculite, non ripristina l’ematopoiesi, né previene la progressione verso l’insufficienza midollare, lasciando irrisolto come la perdita di ADA2 comprometta la funzione delle cellule staminali e progenitrici ematopoietiche (HSPC). Questa tesi caratterizza le HSPC dei pazie...