CARDIOVASCULAR RISK PROFILE IN PATIENTS WITH ONCOLOGICAL AND CHRONIC DISEASES

IMPORTANCE Despite the high cardiovascular risk in multiple myeloma (MM) patients eligible for carfilzomib (K) therapy, the true incidence and spectrum of adverse events (CVAEs), the baseline predictors and validated baseline risk scores to identify the highest-risk patients are unknown due to lacking of real-world data. OBJECTIVES This study aims to prospectively evaluate a cohort of MM patients treated with K (1) determine the true incidence of CVAEs and of subclinical organ injury (2) exam...

Emerging technologies for the exploration and assessment of marine biological resources

CARDIOVASCULAR MECHANICS AND HEMODYNAMICS EVALUATION ACROSS THE SPECTRUM OF HEART FAILURE: FROM DIAGNOSTIC AND PROGNOSTIC ASSESSMENT TO TREATMENT GUIDANCE

Background. Cardiopulmonary hemodynamic assessment is central in heart failure (HF), enabling diagnosis, phenotyping, prognostic evaluation and treatment guidance across the disease spectrum. Right heart catheterization (RHC) remains the gold standard for assessing pressures and flows, while echocardiography allows non-invasive hemodynamic evaluation with increasing accuracy. However, important knowledge gaps persist, resulting in heterogeneous clinical application and uncertainty. Aims. This...

Recovery optimisation of critical raw materials from extractive waste: pathways to a circular economy

Roles of NR2F1 in Hippocampal Circuit Function and Mitochondrial Regulation: Insights into NR2F1-Related Neurodevelopmental Disorder

Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS) is a rare neurodevelopmental disorder caused by pathogenic variants in the gene NR2F1, a nuclear transcriptional regulator with essential roles in brain development and neuronal function. While the clinical phenotype includes cognitive impairments, visual deficits, and autistic traits, the cellular and circuit-level mechanisms linking NR2F1 haploinsufficiency to altered brain function remain poorly understood. This thesis investigates how ...

Boundary Spaces:Behaviour and Semantics of Membrane Transport in Human Cancer

Cancer cells are markedly different from their healthy counterparts. During tumorigenesis, the complex system of the cell, which operates on a different organizational layer than the organism, modifies its regulatory mechanism and begins to disrupt the surrounding tissue. This is due to, specifically, the fact that layer relationships in hierarchical complex systems do not have complete top-down control of their component subsystems. It is clear how tumorigenesis modifies the nature and behav...

Development of Green and White analytical methods for food quality and safety with microwave-assisted sample preparation

Imagine coming home after a long and exhausting day at work, with only one thought in mind: the leftovers waiting in the fridge. You reheat them in the microwave, why? Because it is easy, fast, and efficient. This simple reasoning was the same intuition that inspired Samra et al. when they first introduced microwave technology into the laboratory. The same advantages that make the microwave indispensable in the kitchen can be effectively translated into scientific workflows. Building on this ...

Le eccezioni e limitazioni al diritto d’autore come diritti degli utenti

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Essays in Empirical Macroeconomics

This PhD thesis consists of three chapters that investigate the dynamic interactions among monetary policy, macroeconomic uncertainty, and the business cycle. Chapter 1 focuses on the origins of a particular type of uncertainty, namely macroeconomic downside risk. This concept captures the “worst-case scenario” for the macroeconomy, proxied by the probability that output growth falls below a selected quantile of its predictive density over a given horizon. I investigate the role of monetary p...