Total marrow and lymph nodes irradiation in conditioning regimen for allogeneic hematopoietic stem cell transplantation Artificial Intelligence algorithms to automate the Total Marrow and Lymph-node Irradiation by VMAT optimization using WB-CT/MRI and synthetic WB-CT - The AutoMI project

Purpose/Objective The AuToMI project focuses on improving the TMLI clinical workflow and automating radiotherapy procedures through the application of Artificial Intelligence (AI). The primary goal is to streamline and enhance the efficiency of the radiotherapy treatment process by automating two critical steps: contouring of the target volumes and treatment plan optimization. In parallel, the project aims to integrate whole-body magnetic resonance imaging (WB-MRI) to improve the accuracy of ...

Total marrow and lymph nodes irradiation in conditioning regimen for allogeneic hematopoietic stem cell transplantation Artificial Intelligence algorithms to automate the Total Marrow and Lymph-node Irradiation by VMAT optimization using WB-CT/MRI and synthetic WB-CT - The AutoMI project

Purpose/Objective The AuToMI project focuses on improving the TMLI clinical workflow and automating radiotherapy procedures through the application of Artificial Intelligence (AI). The primary goal is to streamline and enhance the efficiency of the radiotherapy treatment process by automating two critical steps: contouring of the target volumes and treatment plan optimization. In parallel, the project aims to integrate whole-body magnetic resonance imaging (WB-MRI) to improve the accuracy of ...

Antibody-independent activation of complement and its regulation on multiple membrane layers of Plasmodium falciparum-infected erythrocytes

Malaria, caused by Plasmodium falciparum, remains a significant health burden, especially in tropical regions, as the parasite develops within human red blood cells (RBCs). The complement system initiates an early immune response against the parasite, but P. falciparum effectively evades complement-mediated killing. This study investigates how complement proteins deposit and are regulated on infected RBCs (iRBCs) and merozoites in the absence of parasite-specific antibodies. We show that fact...

iPSC-based Models of Genetic Dilated Cardiomyopathy: from Mechanisms to Personalized Therapies

Dilated cardiomyopathy (DCM) is a primary disease of the heart muscle, characterized by enlargement of the left ventricle and systolic dysfunction, which results in progressive heart failure. Approximately 30-50% of cases are familial and are caused by mutations in more than 50 different genes. Among these, sarcomeric protein Titin is the most frequently associated with DCM, accounting for 25% of familiar cases. Although less frequent in DCM cases (4-7%), mutations in LMNA gene, encoding ...

iPSC-based Models of Genetic Dilated Cardiomyopathy: from Mechanisms to Personalized Therapies

Dilated cardiomyopathy (DCM) is a primary disease of the heart muscle, characterized by enlargement of the left ventricle and systolic dysfunction, which results in progressive heart failure. Approximately 30-50% of cases are familial and are caused by mutations in more than 50 different genes. Among these, sarcomeric protein Titin is the most frequently associated with DCM, accounting for 25% of familiar cases. Although less frequent in DCM cases (4-7%), mutations in LMNA gene, encoding ...

Tailoring neuroradiological functional imaging and translational analysis strategies to optimize newly diagnosed GBM volume definition: enhancing surgical resection beyond enhancing boundaries

Complete genetic correction of Duchenne Muscular Distrophy using Chromosome Transplantation in induced pluripotent stem cells

Duchenne Muscular dystrophy (DMD) is a degenerative neuromuscular X-linked disease affecting 1 in 3,500-5,000 new-borns, whose life span is about 25-30 years old. DMD is generally caused by out-of-frame mutations in dystrophin (DMD) gene, leading to the absence of dystrophin protein. Dystrophin is the core part of a complex structure, this so called “dystrophin glycoprotein complex” (DGC), involved in calcium (Ca2+) homeostasis, mitochondrial function, motor protein interaction and muscle spe...

Pathways involved in inflammaging and frailty: the paradigm of visfatin in inflammation and metabolic diseases and the factors influencing the response to COVID-19 vaccines.

Inflammaging and frailty converge on the immune system and contribute to the increased risk of aging-related diseases, serious infections, and reduced response to vaccines. There have been numerous candidate factors contributing to the frail phenotype. The NAMPT/visfatin pathway appears promising for identifying the molecular mechanisms underlying inflammaging, as intracellular NAMPT mediates the production of NAD+, essential for redox homeostasis and for activation of protective and anti-inf...

Complete genetic correction of Duchenne Muscular Distrophy using Chromosome Transplantation in induced pluripotent stem cells

Duchenne Muscular dystrophy (DMD) is a degenerative neuromuscular X-linked disease affecting 1 in 3,500-5,000 new-borns, whose life span is about 25-30 years old. DMD is generally caused by out-of-frame mutations in dystrophin (DMD) gene, leading to the absence of dystrophin protein. Dystrophin is the core part of a complex structure, this so called “dystrophin glycoprotein complex” (DGC), involved in calcium (Ca2+) homeostasis, mitochondrial function, motor protein interaction and muscle spe...