Cancer is still among the major medical concerns worldwide. Although, improvements in chemotherapy and radiotherapy has improved the survival rates of cancer patients, most patients receiving such treatment suffer from some degree of ovarian failure and infertility in future. Ovarian tissue cryopreservation pre-treatment and subsequent transplantation has emerged as a promising strategy for fertility preservation in cancer affected women. However, current cryopreservation protocols are yet to...
In recent years, climate change and energy issues have become prominent in public life. Governments have initiated extensive research into the large-scale production of alternative liquid transportation fuels from renewable resources to reduce the reliance on fossil fuels. Generally, biofuels used in the transportation sector are currently represented mainly by bioethanol and biodiesel. Second and third generation fuels are produce by non-edible crops, as Arundo donax, Populus nigra and Eucal...
STUDY I Nodal is a potent embryonic morphogen belonging to the TGF-beta superfamily. Typically, it binds to the Alk4/ActRIIB receptor complex in the presence of the co-receptor Cripto-1. Nodal expression is physiologically restricted to embryonic tissues and human embryonic stem cells and is absent in normal cells, including melanocytes. However it re-emerges in a number of human cancers, including melanoma, breast and colon cancer. Recent studies indicate that Nodal expression correlates wit...
LO SCOPO DEL PRESENTE STUDIO E' STATO QUELLO DI APPROFONDIRE I DIVERSI ASPETTI DEL TREMATODE DICROCOELIUM DENDRITICUM, PARASSITA A LOCALIZZAZIONE EPATICA DI DIVERSE SPECIE ANIMALI, UOMO COMPRESO. IN PARTICOLARE, D. DENDRITICUM E' STATO UTILIZZATO COME MODELLO DI INTERAZIONE OSPITE-PARASSITA E COME TALE NE SONO STATI CARATTERIZZATI GLI ASPETTI EPIDEMIOLOGICI, BIOLOGICI, PATOLOGICI E BIOLOGICI. I RISULTATI DI QUESTA TESI HANNO DATO UN IMPORTANTE CONTRIBUTO ALLE CONOSCENZE RELATIVE ALLA EPIDEMIO...
Genomic DNA can be covalently modified by methylation, which is layered on the primary genetic information and alters gene expression. There are two patterns of DNA methylation. The first, stable methylation, seen in imprinting, is inherited in a sex-specific fashion and is invariant among individuals and cell types. Unstable or metastable methylation is variable among individuals and cell types and is associated with cancer and aging. The primary cause of somatic DNA methylation is not known...
I tocotrienoli differiscono dai tocotrienoli tra loro per l'insaturazione della catena fitilica laterale. àˆ noto un ampio insieme di proprietà biologiche delle prime isoforme che non sono espresse dai tocoferoli, i cui meccanismi molecolari d'azione sono ancora scarsamente compresi. Recentemente, sulla base delle evidenze sperimentali derivanti da studi in silico e in vitro, ਠstato evidenziato che gli effetti di forme specifiche di tocotrienoli (?- e ?-tocotrienolo) sull'espressione genic...
L'Ipercolesterolemia familiare ਠuna patologia autosomica, codominante, prevalentemente causata da mutazioni del gene del recettore delle LDL (LDL-R). Lo scopo del nostro studio ਠstato valutare il ruolo dei valori di Col-LDL sul profilo di rischio cardiovascolare in una popolazione di pazienti affetti da ipercolesterolemia familiare. Sono stati arruolati 66 pazienti (56,1% donne; età media 42± 14 anni), con le caratteristiche cliniche di FH (Simone Brome Register Criteria), in assenza di ...
Capture fisheries and aquaculture supplied the world with about 148 million tonnes of fish in 2010, of which about 128 million tonnes were utilized as food for people. The fishery market is becoming much more complex and stratified, with greater diversification among species and product forms and for this reason food safety remains a major concern facing the seafood industry. Along fish value chain there are a lot of concern regarding public health and for this reason the aim of this work was...
Small signal stability is a crucial aspect to accurately keep under control in modern interconnected power systems in order to ensure their security and reliability. Such an aspect could represent a serious limiting factor in the search for ever higher power systems exploitation levels. Power oscillations not well-damped may jeopardize the system integrity on large scale: several incidents caused by the establishment of large oscillations have been recorded in the past around the world. Ther...
Photochemistry is a science concerned with structures and dynamical processes resulting from the interaction of the light with molecules. The understanding of molecular processes triggered by the electronic excitation relies on a proper chemical-physical characterization based on a sound theoretical modeling of the photophysics and the photochemistry. From the more strict point of view of the theoretical chemistry, computational methods provide nowadays a powerful tool to analyze and single ...