Xenopus laevis a versatile animal model to study chemical embryotoxicity: the fungicide Triadimefon.

Triazole-derivatives are potent antifungal agents widely used as systemic agricultural fungicides and against fungal diseases in humans and domestic animals. They act by inhibiting the cytochrome P-450 conversion of lanosterol to ergosterol resulting in faulty fungal cell wall synthesis. Some data have been published about the teratogenic activity of triazoles on rodent embryos: hypoplasias, abnormal shape, agenesis of the pharyngeal arches were reported as typical induced malformations. Unf...

Development of novel multi-SiPM systems for biomedical applications

Exploiting the potential of dual-readout calorimetry by introducing a silicon photomultiplier light sensing system

Regulation mechanisms of human D-amino acid oxidase

The human peroxisomal FAD-dependent enzyme D-amino acid oxidase (hDAAO, EC 1.4.3.3) plays a key role in important physiological processes by catalyzing the stereospecific degradation of several D-amino acids (D-AAs). A number of studies demonstrated that a dysregulation in processes regulating D-AAs concentration is related to the mechanism(s) predisposing to several pathologies. The important role played by hDAAO in modulating D-AAs levels increased the interest for this flavoenzyme: while s...

Characteristics and processes of SMEs internationalization: from opportunities and constraints towards the development of strategic networks

The current thesis aims to provide a comprehensive outlook on the small and medium-sized enterprises’ (SMEs) internationalization-related phenomena, by advancing a gradual approach, setting the state-of-the-art as a building block and then passing to the in-depth analysis of underlying issues through articulate empirical studies. In line with this overall approach, the three chapters composing the thesis address three main research objectives: RO1. to identify and discuss the opportunities an...

Storia ambientale dell’energia nucleare. Gli anni della contestazione.

Lo sviluppo rurale nel contesto pedemontano: la dimensione territoriale della 'nuova' agricoltura varesina

The thesis analyzes the role of the agricultural system in the Lombardy foothills context, in particular deepening the phenomena of growth and diversification of farms, referring to the paradigms of rural and local development. The aim of the research is to identify, starting from these peculiarities, the potential and the possible evolution of the role of agriculture in the development of the foothills territories, and in the Varese context in particular, investigating the relationship betwe...

Cryoablation of para-Hisian and mid-septal accessory pathways: long-term outcome of a specific cryoablation protocol

Sguardi tra Cielo e Terra: per una fenomenologia simbolica della Visione. Looks between Heaven and Earth: for a phenomenology of Vision

Cosa vediamo nelle immagini che guardiamo? Qual è il rapporto che il nostro sguardo intrattiene con il Mondo e con il Kosmos? In che modo possiamo renderci visibili a noi stessi attraverso l’esercizio di un’autentica Visione? Come porre le immagini percepite in relazione con la profondità inconscia? E come farle dialogare con l’Anima dell’uomo? Questi sono i principali interrogativi che si è posta la presente ricerca. In particolare, sono state avvicinate le immagini archetipiche che emergon...