Evaluation of DNA methylation role in regulating cell cycle progression and chromosome segregation

Background: Epigenetic regulation is important to ensure the fitness of the cells. To this regard, DNA methylation has the important role of regulating gene expression and heterochromatinization. DNA methylation pattern changes in cancer and during aging. Specifically, cancer cells are characterised by DNA hypermethylation at promoters of tumour suppressor genes, leading to improved proliferation in different microenvironments. Instead, DNA hypomethylation mostly occurs at repetitive sequence...

BIOSTIMULANTS AS SUSTAINABLE TOOLS TO MODULATE GROWTH, PRODUCTIVITY, QUALITY AND TOLERANCE TO ABIOTIC STRESSES OF VEGETABLE CROPS

Next-Generation TRIDs journey: From Rational Drug Design to in vivo Validation

Genetic diseases result from alterations in the DNA sequence that impact either single genes orentire chromosomes. In monogenic disorders specifically, various mutation types can lead to aloss of gene function. Among these, nonsense mutations account for ~11% of hereditarydisorders, for which available treatments remain largely symptomatic rather than curative.Beyond genetic diseases, about 12% of tumour suppressor gene defects are also caused bynonsense mutations.This doctoral research takin...

Beni digitali e profili successori: uno studio di diritto comparato

Integrating Blue Carbon Ecosystem assessments and institutional carbon footprint: toward a holistic approach to climate mitigation

Climate change is a global challenge with profound implications for natural ecosystems, economies and human societies. The primary driver of climate change is the rising atmospheric concentration of greenhouse gases (GHG), particularly carbon dioxide (CO₂), which reflects the balance between anthropogenic emissions and natural carbon fluxes within major carbon reservoirs, such as the terrestrial biosphere and the oceans. Effectively addressing this challenge requires strategies that reduce em...

The role of actinobacteria in growth-promotion and metabolome modulation in Mediterranean plants: nature-based solutions for sustainable food production

Plant-derived bioactive compounds are abundant in Mediterranean species like oregano and tomato, offering valuable applications in human health-related fields. Microbial-based biostimulants (MBBs), particularly those rich in microbes from the phylum Actinomycetota (previously Actinobacteria), represent a promising approach to drive the transition of agricultural systems towards sustainable and better agroecological practices. In this study, two soil Actinomycetota - Streptomyces violaceoruber...

EVALUATION OF NEUROPROTECTIVE POTENTIAL OF KUMQUAT FRUIT AND SELECTED PHYTOCHEMICALS IN DYSMETABOLISM-DRIVEN NEURODEGENERATION: A FOCUS ON BRAIN INSULIN RESISTANCE AND MITOCHONDRIAL BIOENERGETICS

SVILUPPO DI CARRIER POLIMERICI NANOSTRUTTURATI PER LA SOMMINISTRAZIONE INALATORIA DI SORAFENIB NEL TRATTAMENTO LOCALE DEL CARCINOMA POLMONARE

CHARACTERIZATION OF THE BIODIVERSITY OF SICILIAN OLIVE TREE MICROBIOTA AND EVALUATION OF ENDOPHYTES AS PLANT GROWTH PROMOTING AND POTENTIAL BIOCONTROL AGENTS

Plants are the primary producers in terrestrial ecosystems and coexist with a wide community of microorganisms that inhabit almost all plant organs, both above and below ground, both inside and outside their tissues. These microorganisms are involved in intricate networks of interactions that influence plant health and have a significant impact on ecosystem functions. While our understanding of plant microbiota continues to grow, we still lack the ability to fully control these communities, d...