Libera Università Vita-Salute San Raffaele di Milano

Libera Università Vita-Salute San Raffaele di Milano: [651] Istituto

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Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 161 a 180 di 651

Acidosis and metabolic phenotypes in neurodisorders models assessed in vivo by magnetic resonance imaging and spectroscopy

2018

Optical coherence tomography for assessing visual pathway involvement in experimental autoimmune encephalomyelitis

2017

Genetic engineering of HSC to improve engraftment and hematopoietic reconstitution

2017

Development and validation of assays for novel circulating biomarkers of pancreatic inflammation, autoimmunity, and cancer

2017

Network connectivity in dementing diseases

2017

Philosophorum sententias conparans, religionis dogmata confirmans (Hier., ep. 70,4) Origene e la filosofia greca: educazione, testi, lessico

2017

Bordeline personality disorder from emotional dysregulation towards a computational perspective

2017

In vivo human molecular imaging of neuroinflammation and neuronal injury in neurodegenerative conditions and its relationship with pathology

2017

Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of X-linked severe combined immunodeficiency

2017

Analysis of mitochondria and of their role in the activity of the cerebral cortex and its subdivisions

2017

Individui, conoscenza e società un'epistemologia delle virtù per i modelli di democrazia

2017

The multiple faces of cognitive control and the crucial involvement of dorsal anterior cingulate cortex

2016

Esiste una tradizione filosofica italiana? oltre l'Italian thought e altri paradigmi storiografici

2018

Dissecting the role of WASp in platelets studies in a conditional murine model and in WAS patients

2016

Surprise negation sentences expletive negation and the left periphery

2016

Immunosuppressive mechanisms exerted by prostate cancer stem-like cells in the early phase of prostate cancer and lymph node dissemination

2016

L-PGDS in peripheral nervous system regeneration and remyelination

2016

Regulation of phosphoinositide 3-kinase isoforms by pro-inflammatory cytokines Ph. D. program in molecular medicine

2011

Molecular dissection of the human humoral immunoresponse against HSV

2017

Empathy, sympathy and morality an interdisciplinary approach

2014

Istituto	Anno di pubblicazione	Titolo	Autore
Libera Università Vita-Salute San Raffaele di Milano	2018	Acidosis and metabolic phenotypes in neurodisorders models assessed in vivo by magnetic resonance imaging and spectroscopy	-
Libera Università Vita-Salute San Raffaele di Milano	2017	Optical coherence tomography for assessing visual pathway involvement in experimental autoimmune encephalomyelitis	-
Libera Università Vita-Salute San Raffaele di Milano	2017	Genetic engineering of HSC to improve engraftment and hematopoietic reconstitution	-
Libera Università Vita-Salute San Raffaele di Milano	2017	Development and validation of assays for novel circulating biomarkers of pancreatic inflammation, autoimmunity, and cancer	-
Libera Università Vita-Salute San Raffaele di Milano	2017	Network connectivity in dementing diseases	-
Libera Università Vita-Salute San Raffaele di Milano	2017	Philosophorum sententias conparans, religionis dogmata confirmans (Hier., ep. 70,4) Origene e la filosofia greca: educazione, testi, lessico	-
Libera Università Vita-Salute San Raffaele di Milano	2017	Bordeline personality disorder from emotional dysregulation towards a computational perspective	-
Libera Università Vita-Salute San Raffaele di Milano	2017	In vivo human molecular imaging of neuroinflammation and neuronal injury in neurodegenerative conditions and its relationship with pathology	-
Libera Università Vita-Salute San Raffaele di Milano	2017	Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of X-linked severe combined immunodeficiency	-
Libera Università Vita-Salute San Raffaele di Milano	2017	Analysis of mitochondria and of their role in the activity of the cerebral cortex and its subdivisions	-
Libera Università Vita-Salute San Raffaele di Milano	2017	Individui, conoscenza e società un'epistemologia delle virtù per i modelli di democrazia	-
Libera Università Vita-Salute San Raffaele di Milano	2016	The multiple faces of cognitive control and the crucial involvement of dorsal anterior cingulate cortex	-
Libera Università Vita-Salute San Raffaele di Milano	2018	Esiste una tradizione filosofica italiana? oltre l'Italian thought e altri paradigmi storiografici	-
Libera Università Vita-Salute San Raffaele di Milano	2016	Dissecting the role of WASp in platelets studies in a conditional murine model and in WAS patients	-
Libera Università Vita-Salute San Raffaele di Milano	2016	Surprise negation sentences expletive negation and the left periphery	-
Libera Università Vita-Salute San Raffaele di Milano	2016	Immunosuppressive mechanisms exerted by prostate cancer stem-like cells in the early phase of prostate cancer and lymph node dissemination	-
Libera Università Vita-Salute San Raffaele di Milano	2016	L-PGDS in peripheral nervous system regeneration and remyelination	-
Libera Università Vita-Salute San Raffaele di Milano	2011	Regulation of phosphoinositide 3-kinase isoforms by pro-inflammatory cytokines Ph. D. program in molecular medicine	-
Libera Università Vita-Salute San Raffaele di Milano	2017	Molecular dissection of the human humoral immunoresponse against HSV	-
Libera Università Vita-Salute San Raffaele di Milano	2014	Empathy, sympathy and morality an interdisciplinary approach	-

Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 161 a 180 di 651

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AI-HOPE Lung cancer: building a predictive tool for metastatic lung cancer

Metastatic non-small-cell lung cancer (NSCLC) represents a heterogeneous disease with markedly variable outcomes, and reliable prognostic and predictive tools are urgently needed, particularly in the real-world setting. The AI-HOPE study was designed as an ambispective, multicentre project to collect real-world data and develop machine-learning models capable of predicting clinical endpoints in patients with metastatic NSCLC receiving first-line immunotherapy with or without chemotherapy. In ...

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The application of machine learning to healthcare real-world data is emerging as a complementary approach to clinical trials for enabling data-driven decision-making in the evolving population of complex patients managed in the internal medicine setting. To fully realise this potential, significant challenges remain, including data availability and quality limitations and the absence of standardized protocols for model development. In this thesis, we explore how to build an end-to-end machine...

Kant on Analogy: The Problem of Predicating the Noumenon in the Precritical Works

The dissertation aims to analyze Kant’s use of the concept of analogy in his precritical writings, while also reconstructing the historical development of the notion of analogy in order to provide a more accurate historical contextualization of Kant’s works. In doing so, it seeks to demonstrate that the characteristically critical concepts of regulative and constitutive knowledge can be traced back to the precritical period, specifically to Kant’s use of analogy as a means of addressing the p...

CLIMATE CHANGE AND MOTIVATION: VALUES, KNOWLEDGE, EDUCATION

sostenibilità, etica ambientale, filosofia morale, responsabilità individuale e collettiva, cambiamento climatico, educazione ambientale, educazione alla sostenibilità, comunicazione ambientale

The role of MFSD2A in the resolution of colorectal cancer-promoting inflammation: implications for innovative therapies

The intrinsic connection between inflammation and tumor promotion is well established and represents a key pathogenic factor in colorectal cancer (CRC). Therefore, reducing pro-inflammatory milieu without impairing physiological immune defenses or anti-tumor immunity becomes a desirable therapeutic strategy. Endogenous specialized pro-resolving mediators (SPMs), primarily derived from the ω-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid, actively promote th...

Studio degli effetti non cellulo-autonomi della mutazione p.A382T di TDP-43 nelle cellule di Schwann tramite l'utilizzo di un modello in vivo e di un modello in vitro

Il tratto neuropatologico distintivo della sclerosi laterale amiotrofica (SLA), una malattia neurodegenerativa caratterizzata dal coinvolgimento di primo e secondo motoneurone, è la mislocalizzazione, aggregazione e fosforilazione della proteina TDP-43, nota come patologia da TDP-43, nei tessuti affetti. In alcuni casi, nei pazienti con SLA vengono identificate mutazioni in TDP-43, suggerendo che questa proteina abbia un ruolo causale nella malattia. La variante missenso p.A382T è la più comu...

Artificial intelligence of imaging and clinical neurological data for predictive, preventive and personalized medicine for Gliomas

Diffuse gliomas represent the most common malignant primary brain tumors in adults and are now classified according to integrated histopathological and molecular criteria as proposed by the latest WHO CNS5 guidelines. Among the defining molecular alterations, mutations in isocitrate dehydrogenase (IDH) genes have emerged as pivotal for prognosis and therapeutic stratification with substantial implications for clinical outcome. However, current determination of IDH status relies primarily on i...

IN DEPTH CHARACTERIZATION OF MONOCYTE-B CELL INTERACTIONS IN INFECTION AND CANCER

B cells are central to adaptive immunity, but many viruses interfere with their functions. For instance, our group previously described that, in the context of infection with the poorly cytopathic Lymphocytic Choriomeningitis Virus (LCMV), monocytes recruited to the draining lymph nodes (dLNs) mediate the killing of virus-specific B cells, hindering the generation of neutralizing antibodies. This reveals an unexpected level of monocyte-mediated regulation of humoral immunity, although the und...

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Il deficit di adenosina deaminasi 2 (DADA2) è una rara malattia autosomica recessiva caratterizzata da infiammazione sistemica, disregolazione immunitaria e insufficienza midollare. Sebbene la terapia anti-TNF controlli la vasculite, non ripristina l’ematopoiesi, né previene la progressione verso l’insufficienza midollare, lasciando irrisolto come la perdita di ADA2 comprometta la funzione delle cellule staminali e progenitrici ematopoietiche (HSPC). Questa tesi caratterizza le HSPC dei pazie...

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