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Libera Università Vita-Salute San Raffaele di Milano: [285] Istituto

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Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 61 a 80 di 285
Istituto Anno di pubblicazione Titolo Autore file(s)
Libera Università Vita-Salute San Raffaele di Milano 2024 La perdita di Acquaporina11 impedisce la corretta biogenesi di Policistina-1 attraverso l'accumulo di H2O2 nel Reticolo Endoplasmatico -
Libera Università Vita-Salute San Raffaele di Milano 2010 Identification of the molecular mechanisms responsible for epilepsy associated with mutation in human synapsin 1. -
Libera Università Vita-Salute San Raffaele di Milano 2010 Luminescent chimeric probes for the development of a new protein translocation screening assay and for the study of cell death. -
Libera Università Vita-Salute San Raffaele di Milano 2010 Optimization of structural and functional MRI techniques to study the human cervical spinal cord with application to aging and neurological disorders. -
Libera Università Vita-Salute San Raffaele di Milano 2010 brain electroencephalographic (EEG) rhythms source analysis in neuropsychiatric disorders. -
Libera Università Vita-Salute San Raffaele di Milano 2010 Physiological and pathological role of Drosophila Atrophin in planar polarity and neurodegeneration. -
Libera Università Vita-Salute San Raffaele di Milano 2010 The focal implantation of neural stem/precursor cells (NPCs) ameliorates a contusion spinal cord injury mouse model. -
Libera Università Vita-Salute San Raffaele di Milano 2010 Constitutive and inflammatory pathways of T cells trafficking into the CNS during experimental autoimmune encephalomyelitis. -
Libera Università Vita-Salute San Raffaele di Milano 2010 The role of liprins in cell and growth cone motility. -
Libera Università Vita-Salute San Raffaele di Milano 2010 The soluble pattern recognition receptor Pentraxin 3 plays protective activities in microbial infections through the interplay among complement, complement receptors and Fcγ receptors. -
Libera Università Vita-Salute San Raffaele di Milano 2010 MHC class 2. transactivator : a novel in vivo regulator of osteoclastogenesis and bone homeostatis. -
Libera Università Vita-Salute San Raffaele di Milano 2010 Editing T-cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer. -
Libera Università Vita-Salute San Raffaele di Milano 2010 Foot pad skin biopsy in mouse models of hereditary neuropathy. -
Libera Università Vita-Salute San Raffaele di Milano 2010 The role of c-jun N-terminal kinase (JNK)/Apoptosis/Inflammation-pathway in Multiple Sclerosis (MS). -
Libera Università Vita-Salute San Raffaele di Milano 2010 Induction of antigen-specific tolerance by means of cytokine-or lentiviral vector-modulated human dendritic cells. -
Libera Università Vita-Salute San Raffaele di Milano 2010 Exploring signal events elicited by chemotactic-receptor engagement in migrating cells. -
Libera Università Vita-Salute San Raffaele di Milano 2010 The use of different and complementary techniques for the study of human cognition. -
Libera Università Vita-Salute San Raffaele di Milano 2010 Non-invasive neuromodulation by tDCS in mice : electrophysiological evidence. -
Libera Università Vita-Salute San Raffaele di Milano 2010 Iron-entry and neurotoxic effects in hippocampal neurons : a role for calcium-permeable channels. -
Libera Università Vita-Salute San Raffaele di Milano 2010 The involvement of mitochondria in cellular iron dynamics and ROS generation in unaffected and neurodegenerative disease cellular models. -
Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 61 a 80 di 285
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Degenerazione assonale nelle neuropatie periferiche: dai meccanismi molecolari all’approccio terapeutico

La malattia di Charcot-Marie-Tooth (CMT) è la neuropatia periferica ereditaria più frequentemente osservata, con una prevalenza di circa 1 su 2.500 persone. È un gruppo di patologie geneticamente eterogeneo, con mutazioni in oltre 100 geni, che colpisce sia i nervi motori sia quelli sensoriali. La mutazione T124M nel gene MPZ dà origine alla CMT2J, un sottotipo particolarmente interessante con una particolare prevalenza nell’Italia settentrionale. Sebbene MPZ sia una proteina esclusivamente e...

Lo studio dell'età cellulare sulla funzione delle β cellule derivate da iPSC

Una fonte affidabile di β cellule è essenziale per l'avanzamento della terapia cellulare nel diabete di tipo 1. Le cellule staminali pluripotenti indotte possono differenziarsi in β cellule produttrici di insulina, imitando efficacemente lo sviluppo pancreatico in vitro. Mentre la senescenza cellulare supporta la formazione di β cellule durante l'embriogenesi, la loro senescenza cellulare legata all'invecchiamento compromette il rilevamento del glucosio e la secrezione di insulina. Tuttavia, ...

Imaging, genetic and biomarkers characterization of arrhythmic mitral valve prolapse

Association between genotype and phenotype in mitral valve prolapse patients and their impact on arrhythmic outcomes

Digital Cognitive Assessment and its Relationship with Disability in Multiple Sclerosis

Introduction. Cognitive impairment is common in people with MS (pwMS) and significantly impacts functional independence. The Symbol-Digit Modalities Test (SDMT) is widely used to assess cognitive deficits in pwMS. Electronic adaptations of the SDMT (eSDMT) can enable remote monitoring and capture more detailed performance metrics, compared to pen-and-paper tests. This study details the development and validation of a custom-made eSDMT intended to enable long-term remote cognitive monitoring o...

At-home extension of computerised cognitive rehabilitation in People with Progressive Multiple Sclerosis: A Feasibility and Efficacy Pilot Randomised Controlled Trial

A great proportion of People with Multiple Sclerosis (PwMS) suffers from Cognitive Impairment (CI), which greatly diminishes the quality of life of those affected. Pharmacological treatments for CI in PwMS showed limited efficacy, and behaviourally-based interventions still remain the preferred care option. These typically involve in-clinic repeated one-on-one sessions with a therapist for a set period of time. This has been seen to be both costly and unfeasible for some PwMS. Telerehabilitat...

FUTURE-MAKER-GENERATIONS. CRITICAL PHENOMENOLOGY AND TRANSGENERATIVE SOCIAL ONTOLOGY

This thesis introduces the concept of Future-Maker Generations (FMGs), a novel form of plural subject described as an ethical and political community, globally disseminated and axiologically oriented towards the defence of plurality of all forms of life. The thesis aims to describe and analyse the emerging of FMGs from Future-Maker Personalities (FMPs), individuals united by a shared set of values oriented towards human plurality, global solidarity, human rights, and environmental protection....

LNA-ASO based therapy for the treatment of SARS-CoV-2 infection in pre-clinicals models

The COVID-19 crisis and the development of the first approved mRNA vaccine have highlighted the potential of RNA-based therapeutic strategies. Mutated variant strains of SARS-CoV-2 that evade immunity to previous infection or vaccination are continuously emerging, resulting in new outbreaks. Thus, there is a clear and urgent need for alternative approaches that are active against multiple variants of concern. Antisense oligonucleotides (ASOs) represent a new and promising class of RNA-targete...

Pregnancy during a pandemic: a deep phenotyping approach exploring the role of inflammation on postpartum cognitive decline and depression.

Peripartum depression (PPD) results in physical, emotional, and behavioral changes during pregnancy and postpartum that occur in roughly 20% of women, yet COVID-19 may have increased the prevalence of PPD. Furthermore, during this period, women may be vulnerable to the development of cognitive deficits. The biological causes of PPD and cognitive decline are still unclear. These issues may arise due to brain structural and functional alterations; however, results are inconclusive. Moreover, dy...

FUNCTIONAL AND STRUCTURAL MRI CORRELATES OF COGNITIVE DYSFUNCTION IN PEDIATRIC MS AND A COMPARISON OF COGNITIVE RESILIENCE WITH ADULT-ONSET MS

During my PhD, I focused on the study of the MRI substrates of cognition in pediatric-onset (PO) multiple sclerosis (MS) patients and on the validation of a novel paper-pencil cognitive test, the Consecutive-letter Substitution Test (CST), to assess information processing speed (IPS). By applying unsupervised machine learning, we identified three cognitive phenotypes in pediatric MS patients: normal functioning, mild verbal memory and semantic fluency deficits, and global impairment, each as...

Trust, Science and Disinformation

In this dissertation, my aim is to analyse the reasons and causes behind the spread of disinformation. In particular, my main interest is in what I will refer to as “scientific disinformation”, namely the kind of disinformation that regards scientific issues and topics, with a particular focus on climate change. The thesis is divided into five chapters, each with a specific purpose. The first chapter is dedicated to the definition of disinformation. I review the different definitions of disin...

Scopri
Istituto
  • Libera Università Vita-Salute San...285
Data di pubblicazione
  • 2020 - 2025200
  • 2010 - 201944
  • 2004 - 200941
Settore disciplinare
  • Settore BIO/11 - Biologia Molecolare31
  • Settore MED/26 - Neurologia21
  • Settore BIO/13 - Biologia Applicata20
  • Settore MED/04 - Patologia Generale20
  • Settore M-PSI/02 - Psicobiologia ...8
  • Settore MED/25 - Psichiatria7
  • Settore M-FIL/01 - Filosofia Teor...5
  • Settore M-FIL/03 - Filosofia Morale4
  • Settore M-FIL/05 - Filosofia e Te...4
  • Settore MED/15 - Malattie del Sangue4
Accesso al fulltext
  • open158
  • internalNetwork68
  • embargoed36
  • no fulltext10
  • mixed7
  • reserved6