Genome stability is important for organisms and its maintenance depends significantly on the successful activation of the DNA damage response (DDR) and the role of non-canonical chromatin structures (NCSs), which regulate genome replication, transcription and DNA repair.
In senescent cells, defective DDR often results in the accumulation of unrepaired DNA damage.
Among NCSs, R-loops are three-stranded RNA-DNA hybrids, consisting of a nascent RNA strand that attaches to the DNA template, for...
Questa tesi esamina la rilevanza della lista come pattern retorico nel corpus di Wulfstan, concentrandosi su come l'Arcivescovo enumera malfattori e reati nelle sue opere omiletiche e legalistiche. I primi due capitoli si concentrano sulla carriera di Wulfstan come predicatore e consigliere reale durante gli anni di crisi politica e morale che hanno caratterizzato i regni di re Etelredo II e Canuto il Grande. Esaminando le opere di Wulfstan nel loro contesto culturale, è possibile comprendere...
In the context of modern manufacturing, where flexibility, automation, and cost-effectiveness are increasingly critical, robotic milling is gaining traction as a viable alternative to traditional CNC machining in a variety of industrial applications. However, despite its versatility, robotic milling remains significantly more challenging due to the inherent compliance of industrial robotic arms, which compromises both stability and process reliability. In this scenario, the development of rob...
Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the gastrointestinal tract. Interstitial cell of Cajal is considered to be its precursor. In contrast to most sarcomas, which have no known premalignant lesions, preneoplastic counterparts of GIST, known as mini-GIST have been identified. Although malignant GIST are rare, mini-GIST are remarkably common, with an incidence of 20-30% in the elderly population. The vast majority of mini-GIST display benign nature, but a fraction...
This study explores fictional representations of hospitality in the novels and short stories of two notable early 20th-century authors, E. M. Forster and Joseph Conrad. The thesis investigates these authors’ engagement with the theme of hospitality as a foundational literary topos in Western literature, and it analyses how ethical issues posed by the hospitality relation operate within fictional texts at the level of theme, mode, setting, ideology, and narrative technique. The research begins...
The research work illustrate the development of catalyst-promoted Fe-based Oxygen Carriers (OC) for the Chemical Looping Steam Reforming (CL-SMR) process. Goal of the study was to explore novel methods for preparing oxygen carrier materials that combine the advantages of Fe-containing oxides, including environmental compatibility, relatively low cost, and the ability to be partially or fully reoxidized by steam, with the high CH4 activation ability of Ni. The process enables the simultaneous ...
Being one of the most prevalent forms of cancer, colorectal cancer (CRC) represents a significant public health concern. Mast cells (MCs) are immune cells involve in the maintenance of intestinal homeostasis as well as in orchestrating inflammation. The link between persistent inflammation and tumour transformation is an established knowledge and MCs are increasingly recognised as potential crucial players in tumor progression. CRC is characterized by an intimate interaction with microbiota w...
Investigating the structural integrity of components produced by additive manufacturing (AM) presents unique challenges, particularly when the component is subjected to cyclic loads. Process-induced defects and a peculiar non-equilibrium microstructure strongly influence the fatigue properties. These challenges are further amplified when architected cellular materials (or cellular structures) are involved, as they introduce a structural vulnerability due to the notches in the cell shape. In t...
La ricerca su Enrico Castelnuovo (Roma, 26 maggio 1929-Torino, 15 giugno 2014) che qui si presenta non segue un’impostazione strettamente biografica, per approfondire piuttosto una serie di questioni sorprendenti, rimaste ai margini dei ritratti dello studioso già consolidati. In questa ricostruzione ha piena centralità l’archivio privato di Castelnuovo, oggetto di riordino e schedatura analitica da parte di chi scrive.
Nel primo capitolo della tesi si cerca un ritratto di Castelnuovo a part...
In questo lavoro proponiamo un nuovo metodo per la sistematizzazione dei significati dei prefissi verbali russi (PVR) che sia fruibile per le necessità pratiche di discenti, traduttori e interpreti, che chiamiamo “approccio integrato” e testiamo sul caso specifico della prospettiva traduttologica. Infatti, dal momento che i PVR compongono la maggior parte del lessico verbale russo e sono altamente polisemici, essi rappresentano una sfida notevole per gli italofoni che studiano o lavorano col ...