Host-targeting strategies for the development of novel therapeutics to fight viral infections

Viral infections impose a significant economic and healthcare burden on society, markedly contributing to mortality rates, especially in the case of newly emerging or re-emerging viruses with pandemic potential. The range of therapeutic options available to combat these threats mainly consists of vaccines and antivirals, which are, however, unevenly distributed and applicable; moreover, the availability of safe and effective interventions largely depends on the specific pathogen involved. To ...

Il principio del risultato amministrativo e la “buona amministrazione” tra teoria generale e razionalizzazione del “sistema appalti”

Il principio del risultato amministrativo e la “buona amministrazione” tra teoria generale e razionalizzazione del “sistema appalti L’avvento di nuove fenomenologie del reale ha comportato la destrutturazione delle tradizionali logiche che conformavano l’esercizio unilaterale e imperativo del potere pubblico. La progressiva dequotazione della legalità, tradizionalmente intesa dalla dottrina amministrativistica, è stata accompagnata da nuovi tentativi di inquadramento del giudizio di conformi...

INFLUENCE OF DENTAL MALOCCLUSIONS AND THEIR ORTHOGNATHODONTIC TREATMENT ON MASTICATION AND POSTURE

This Ph.D. thesis presented and critically discussed scientific papers published (or, in one instance, submitted and currently under peer review) during the course of the four years of the program. These papers were grouped together because a thread runs through them all: the functional approach to clinical orthodontics. Malocclusions negatively affect the functions of the stomatognathic system, and an in-depth understanding of their functional consequences is necessary if long-term stability...

Les journaux d’Henry Bauchau comme lieu d’élaboration d’OEdipe et d’Antigone: entre réélaboration mythique et génétique littéraire

Cette thèse propose une interprétation de l’oeuvre romanesque d’Henry Bauchau à partir de ses journaux, envisagés non comme documents périphériques mais comme matrices structurantes de la création. En mobilisant une approche génétique et philologique, il analyse la genèse d’OEdipe sur la route (1990) et d’Antigone (1997) à partir d’un corpus envisagé dans sa continuité (1954-2012). La mise en relation systématique des journaux, des manuscrits, des brouillons et des textes publiés permet de re...

B7-H3 AS A STRATEGIC TARGET FOR CAR-CYTOKINE INDUCED KILLER LYMPHOCYTES IMMUNOTHERAPY TO ELIMINATE CHEMORESISTANT CANCER STEM CELLS ACROSS DIVERSE TUMOR TYPES

Evaluation of Cellular Senescence in Lung Tissue of Patients with Chronic Obstructive Pulmonary Disease (COPD) and Idiopathic Pulmonary Fibrosis (IPF)

Introduction: Chronic Obstructive Pulmonary Disease (COPD) and Idiopathic Pulmonary Fibrosis (IPF) are respiratory disorders strongly associated with advanced age and premature cellular senescence. Senescent cells are commonly identified by senescence-associated β-galactosidase or by cell cycle inhibitors such as p16 and p21. However, they can also be evaluated by measuring senescence-associated products, such as lipofuscin. Sudan Black B (SBB) has been recently recognized as a specific lipof...

Mapping the ripple effects: how social inequalities shape multimorbidity in an aging society

This thesis examines how socioeconomic inequalities shape the development of multimorbidity, defined as the coexistence of two or more chronic conditions, in aging populations. Although rising life expectancy has led more people to live longer with chronic disease, increases in healthy life years have not kept pace, creating a growing burden of disability, healthcare use, and diminished quality of life. Multimorbidity is heterogeneous, involving clusters of physical and mental disorders, and ...

Air pollution and Multiple Sclerosis. Exposure to particulate matter (PM) selectively triggers molecular and behavioral changes in a preclinical model of Multiple Sclerosis

Functional characterization of long non-coding RNAs involved in the epigenetic regulation of human neural development

The aim of this thesis is to provide a comprehensive investigation into the role of long non-coding RNAs (lncRNAs) in human brain development and neuronal specifi cation, using as experimental models both human embryonic stem cell (hESC)-derived cortical organoids (hCOs) and canonical in vitro hESCs-derived neural progenitor cells (NPCs) and terminal diff erentiated cortical neurons (TDCNs). We employed a computational workfl ow to identify a repertoire of the most promising lncRNA candidates...