UNDERSTANDING HEALTH INEQUITIES IN NONCOMMUNICABLE DISEASES: AN EPIDEMIOLOGICAL PERSPECTIVE USING THE SYNDEMIC FRAMEWORK

This thesis employs a syndemic framework to examine how social and structural inequities influence the development, co-occurrence, and progression of non-communicable diseases (NCDs). Combining epidemiological methods and anthropological and social theory, it aims to move beyond individual-level risk factors and to describe the processes through which socioeconomic inequalities shape disease clustering. Specifically, the thesis applies the syndemic framework to two longitudinal cohorts, the P...

Polymers and additives from renewable sources for sustainable products and processes

LA FIGURE DU FILS: PALIMPSESTES MYTHIQUES ET BIBLIQUES DE NATHACHA APPANAH, EDEM AWUMEY, AMÉLIE NOTHOMB ET CAMILLE DE TOLEDO

This thesis offers a comparative study of the figure of the son in four contemporary Francophone novels: Tropique de la violence by Nathacha Appanah, Les pieds sales by Edem Awumey, Soif by Amélie Nothomb, and Thésée, sa vie nouvelle by Camille de Toledo. Drawing on a mythocritical and biblico-literary approach, the research explores the metamorphoses of the mythical and biblical archetype of the son in a literary context marked by a crisis of foundations and the dislocation of collective nar...

DECODING COMPLEXITY:HARMONISATION OF MODELLING PARADIGMS

Rationale Computational modelling is a cornerstone of Systems Biology, enabling mechanistic insights into complex biological systems. Computational models are crucial for addressing critical questions about system evolution and deciphering system connections. To gain recognition within the biological and clinical communities, these models must offer a holistic view of the entire system while simultaneously allowing inspection of its components at varying levels of granularity. Results This Ph...

NOVEL SYNAPTIC, BLOOD-BASED, AND NEUROIMAGING BIOMARKERS IN ALZHEIMER’S DISEASE AND RELATED DEMENTIAS: INSIGHT INTO PATHOPHISIOLOGY AND CLINICAL IMPLEMENTATION

Alzheimer’s disease (AD) and related dementias require accurate biomarkers to support early diagnosis, improve differential classification, and enable access to emerging therapies. This thesis examined novel biomarker candidates through different approaches - cerebrospinal fluid-based, blood-based, and neuroimaging - providing novel perspectives on their potential clinical and research applications. A systematic review and meta-analysis demonstrated that synaptic proteins such as neurogranin,...

Salus populi suprema lex esto? Popolo e giacobinismo nei progetti costituzionali del «celebre Concorso» del 1796

Occuparsi di Triennio repubblicano (1796-1799) implica incappare nella cosiddetta «questione del giacobinismo italiano», che vide impegnati gli storici e le storiche in un prolifico dibattito durante il secondo dopoguerra. A partire dalla fine degli anni ’90 del Novecento, l’aggettivo che si è attestato come il più adatto a descrivere il Triennio è «Repubblicano», ed è in effetti il più appropriato dal momento che in Italia non solo le Repubbliche sorelle erano di fatto modellate sulla Franci...

Le ambivalenze della protezione in Karl Polanyi

A partire dalle molteplici interpretazioni a cui il pensiero di Karl Polanyi è stato sottoposto la tesi indaga le ambivalenze del concetto di protezione nel pensiero di Karl Polanyi. A tal fine la ricerca scava nella produzione in diverse lingue - inglese, tedesca e ungherese - ricostruendo criticamente le influenze intellettuali di Polanyi. Polanyi emerge così come un pensatore socialista, formatosi su Tolstoj e il neokantismo, particolarmente influenzato dal guild socialism e dall’austroma...

Development of Mass Spectrometry based methods for bioactive molecule characterization

This doctoral thesis focuses on the development and application of mass spectrometry (MS)-based analytical workflows for the detection, characterization, and quantification of small bioactive molecules and potential molecular markers in complex matrices of environmental, microbial, plant, and human origin. Rather than targeting a single class of compounds or relying on a fixed instrumental platform, the approach prioritizes methodological flexibility, tailoring each step—from sample preparati...

Both/And Entrepreneurial Ecosystems: Illuminating Underexplored Mechanisms and Contexts through a Paradox Theory Lens