Artificial intelligence and machine learning applications in Nuclear Medicine for the identification of predictive and prognostic factors in oncological and endocrinological diseases

Recent technological advances, combined with the increasing volume of data available in electronic health records, have paved the way for the application of artificial intelligence (AI) and machine learning (ML) in the medical field. ML is a branch of AI that uses algorithms trained on available observations in order to predict the output of future input data. Nuclear medicine, which has grown to play a key role in the diagnostic work-up and treatment of various cancers, represents an ideal s...

Evaluation of the prevalence and clinical-laboratory characteristics of Intolerance to single and multiple drug classes in hypertensive subject (MDI-TO)

Multiple Drug Intolerance (MDI) is a clinical condition where adverse drug reactions (ADRs) occur in at least three drug classes without an immunological mechanism. MDI pathogenesis mechanism has not been clarified yet and no in-vitro tests are available for its diagnosis, often carried out through an exclusion process. There are few studies in literature focused on identifying the mechanisms and clinical determinants of MDI. In the context of Arterial Hypertension, the use of combination the...

New heterogeneous sustainable catalysts and process intensification technologies for the development of industrial synthetic protocols

Introduction and evaluation of fall detection technologies for fall prevention in older adults at home

In vitro and in vivo efficacy of innovative integrin-targeted photosensitizers for photodynamic therapy

Green Solid Lipid Nanoparticles by the Fatty Acids Coacervation: an innovative Drug and Gene delivery tool for various applications

Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers are nanospheres made up of solid and solid-liquid lipids, respectively. However, they are usually obtained by methods involving either high temperatures and complex equipment or toxic solvents. Therefore, such techniques are associated to several hurdles and high costs. Among alternative formulation techniques, the fatty acid coacervation allows to obtain fatty acid-based SLNs from the corresponding alkaline soaps, owing to si...

THE PATH OF ALPINE SUSTAINABILITY. PARTICIPATORY TOOLS FOR TAKING CARE OF THE CULTURAL AND ENVIRONMENTAL HERITAGE OF THE MONTE ROSA MASSIF (NW-ALPS, ITALY)

Creating a valuable and effective geotourism initiative, such as geotrail, requires significant effort and a multidisciplinary approach. Geotourism aims to disseminate geoscientific knowledge, protect geological heritage, and support regional sustainable development. In the context of growing interest in UNESCO Global Geoparks (UGGp) and the role of geodiversity in ecosystems, it is crucial to develop initiatives rooted in scientific research and modern communication strategies. This thesis o...

Freshwaters in a changing climate: effects of water scarcity on the (photo)chemistry of Alpine streams

The term “alpine” has two quite different meanings. When the word is capitalized, Alpine streams refer to running waters of the Alps, at any elevation. When not capitalized, alpine streams refer to running waters of the alpine zone above the tree line, anywhere in the world. In this PhD thesis, the first context was adopted. The work described in the following sections sought to examine, at least in part, the effects of climate change-related drought conditions on the chemistry of streams bor...

NOVEL DISEASE GENES DISCOVERY AND INNOVATIVE APPROACHES FOR INVESTIGATING NEURODEVELOPMENTAL DISORDERS

Neurodevelopmental disorders (NDDs) encompass a wide range of conditions, including Autism Spectrum Disorders (ASD), intellectual disability (ID), language delays, and epilepsy. These disorders exhibit significant genetic heterogeneity, involving all modes of inheritance. In the last years, the development of high-throughput technologies, like next-generation sequencing, has given the possibility to unravel the genetic mechanisms behind NDDs, and helped patients and their families to shorten ...