Tuneable mid-infrared sources for spectroscopy through difference frequency generation in Lithium Niobate ridge waveguides

Over the past two decades, significant advancements have been made in the miniaturization of mid-infrared (MIR) spectroscopy sources. However, achieving a fully integrated solution presenting high optical power and wide tuneability within the so-called atmospheric window (2.5 – 5 μm) remains an open challenge. This thesis explores the development of a broadband, frequencytuneable MIR source exploiting the effect of difference frequency genera tion (DFG) in a Periodically Poled Lithium Niobate...

Biocatalytic green transition of industrial processes to produce cephalosporin and carbapenem antibiotics

Il lavoro di tesi si concentra sullo studio e ottimizzazione della sintesi enzimatica della cefazolina, un antibiotico cefalosporinico ampiamente utilizzato in ambito clinico. L’obiettivo è proporre un processo alternativo al metodo chimico tradizionale, caratterizzato dall’uso di solventi tossici e reagenti clorurati, sviluppando una sintesi sostenibile e scalabile a livello industriale. La reazione, sotto controllo cinetico, tra 7-ZACA e TZA-Me, catalizzata dall’enzima PGA, offre significat...

Origin of mafic-ultramafic rock sequences from the Ivrea Mafic Complex (Southern Alps): new insights into the process of magmatic underplating

A Versatile Workflow for Building 3D Hydrogeological Models Combining Subsurface and Groundwater Flow Modelling: A Case Study from Southern Sardinia (Italy)

This research project aims to develop a basin-scaled 3D hydrogeological model by using Petrel E&P (Petrel 2021© ) as the basis for a numerical groundwater flow model developed with “ModelMuse”. A relevant aspect of the project is the use of Petrel 2021© geologic modelling tools in the field of applied hydrogeology to improve the details of both hydrogeological and numerical groundwater flow models, and their predictive capabilities. The study area is located in South Sardinia (Campidano Plai...

Plio-Pleistocene Evolution of the Po Plain Subsurface: Insights from a 3D Geological Model and its Relationship with the Occurrence of Thermal Anomalies for Geothermal Energy Exploration

Biopharmaceuticals analysis using innovative orthogonal characterization techniques

Development of an Innovative Three- Dimensional Cell Culture for Modelling and Treating Endometriosis Exploiting Gold Nanoparticles

Dual targeting of cell-surface tumour antigens and soluble TGF beta by CAR-T cells – a novel approach to cancer immunotherapy

Liver cancer is a significant public health concern worldwide, being one of the solid tumours that pose a major challenge (Villanueva A., 2019). According to projections by the International Agency for Research on Cancer (IARC), the number of cases is expected to reach approximately one million annually by 2025. The most prevalent type of primary liver cancer is Hepatocellular carcinoma (HCC), which accounts for around 90% of liver cancer cases. The Tumour Microenvironment (TME) of HCC is cha...

Photocatalysis for the exploitation of fish and agri-food waste and synthesis of advanced polymers and carbon nanomaterials

Il progetto si focalizza sulla valorizzazione degli scarti dell'industria agro-alimentare, in particolare sull'estrazione di bio-molecole da residui di pesce e frutta (in collaborazione con Rigoni di Asiago) e sulla successiva conversione dei rifiuti in Carbon Dots (CDs). Il principale obiettivo è l'utilizzo dei CDs come fotocatalizzatori in reazioni organiche, tra cui: • 1,2 Di-funzionalizzazione di olefine con alogenuri alchilici tramite reazioni di Atom Transfer Radical Addition (ATRA) • ...