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Università degli Studi di Milano: [5939] Istituto

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Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 1 a 20 di 5.939
Istituto Anno di pubblicazione Titolo Autore file(s)
Università degli Studi di Milano 2025 THERAPEUTIC POTENTIAL OF TARGETING THE FLNA-REGULATED WEE1 KINASE PATHWAY IN ADRENOCORTICAL CARCINOMAS. -
Università degli Studi di Milano 2025 UNVEILING HUMAN NATURAL KILLER CELLS ONTOGENESIS IN HOMEOSTATIC CONDITIONS AND DURING THE IMMUNE RECONSTITUTION AFTER HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION -
Università degli Studi di Milano 2025 GUT ABSTRACTIONS. A PHILOSOPHICAL STUDY FOR THE PRESENT OF FOOD. -
Università degli Studi di Milano 2024 UNDERSTANDING METASTASIS MIXED - TREATMENT RESPONSES THROUGH GENOMIC ANALYSES. -
Università degli Studi di Milano 2024 CARDIOVASCULAR AUTONOMIC IMPAIRMENT IN GBA PARKINSONIAN PATIENTS -
Università degli Studi di Milano 2024 IDENTIFICATION OF GENETIC VARIANTS THROUGH WHOLE EXOMESEQUENCING IN PHENOTYPES WITH SKELETAL CLASS IIMALOCCLUSION BAD RESPONDERS -
Università degli Studi di Milano 2024 THE ROLE OF MOLECULAR SIGNATURES IN COMPLICATED CELIAC DISEASE -
Università degli Studi di Milano 2025 PEPTIDOGLYCAN REMODELLING FACTORS: KEY PLAYERS IN CELL DIVISION AND HOMEOSTASIS MAINTENANCE OF ESCHERICHIA COLI -
Università degli Studi di Milano 2024 ANTIBODY-DRUG CONJUGATES FOR THE TREATMENT OF BREAST CANCER. -
Università degli Studi di Milano 2024 MIR-181A/B INHIBITION AS A NEW STRATEGY FOR MITOCHONDRIAL DISEASE TREATMENT -
Università degli Studi di Milano 2024 SARCOPENIA, LIVER AND CARDIOVASCULAR ALTERATIONS IN A MULTICENTRIC COHORT OF PATIENTS WITH MASLD: EVALUATION OF CLINICAL PRESENTATION AND GENETIC PREDISPOSITION -
Università degli Studi di Milano 2024 PTH RESISTANCE SYNDROMES: AGE-DEPENDENT CLINICAL PICTURE AND EMERGING UNCOMMON FEATURES -
Università degli Studi di Milano 2024 CLINICAL AND RADIOGRAPHIC EVALUATION OF MARGINAL BONE RESORPTION OF ONE-PIECE IMPLANTS IN FULL ARCH REHABILITATIONS WITH FULL DIGITAL APPROACH: A PROSPECTIVE COHORT STUDY. -
Università degli Studi di Milano 2024 A HISTORICAL INSTITUTIONALIST ACCOUNT OF GALILEO SATELLITE NAVIGATION. -
Università degli Studi di Milano 2024 AI-DRIVEN ATRIAL ARRHYTHMIA DETECTION: DEVELOPMENT, CROSS-COMPARISON AND UNCERTAINTY QUANTIFICATION OF ALGORITHMS FOR CLINICAL CONTINUOUS ECGS -
Università degli Studi di Milano 2024 QUANTUM AND TRANSLUCENT PARADIGMS IN AUTOMATA THEORY: A STUDY ON COMPUTATIONAL CAPABILITIES -
Università degli Studi di Milano 2024 DETERMINATION OF CONTAMINANTS IN FISHERY PRODUCTS TO SUPPORT FOOD SAFETY -
Università degli Studi di Milano 2025 LIQUID PLASTICS AS A NEW ENVIRONMENTAL PROBLEM? AN INTEGRATED RISK ASSESSMENT OF POLYVINYL ALCOHOL, POLYETHYLENE GLYCOL, POLYVINYL PYRROLIDONE AND POLYACRYLIC ACID -
Università degli Studi di Milano 2025 L'AUTONOMIA NELL'APPRENDIMENTO DELLO SPAGNOLO COME LINGUA STRANIERA. NUOVE PROSPETTIVE DIDATTICHE E PEDAGOGICHE NELLO SCENARIO (POST)PANDEMICO -
Università degli Studi di Milano 2024 BEES AND WASPS IN A CHANGING ENVIRONMENT: MULTIPLE RESPONSES TO ANTHROPISED LANDSCAPES -
Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 1 a 20 di 5.939
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Prodotti recenti

THERAPEUTIC POTENTIAL OF TARGETING THE FLNA-REGULATED WEE1 KINASE PATHWAY IN ADRENOCORTICAL CARCINOMAS.

Adrenocortical carcinomas (ACC) are highly aggressive tumors with very limited treatment options. Alterations in cell cycle-related genes have been identified as key ACC drivers, and they are largely present in the most aggressive tumor subtypes. Compared to benign adenomas (ACA), the cytoskeletal protein filamin A (FLNA) is poorly expressed in ACC. Of note, its presence, even at low levels, is associated to a less aggressive tumor behaviour, potentially due to its role in negatively regulat...

UNVEILING HUMAN NATURAL KILLER CELLS ONTOGENESIS IN HOMEOSTATIC CONDITIONS AND DURING THE IMMUNE RECONSTITUTION AFTER HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION

Natural Killer (NK) cells are potent members of the innate immune system, as they are endowed with the capacity of sensing and eliminating tumor-transformed and viral infected cells by integrating a plethora of inhibitory and activating signals coming from a repertoire of germline encoded receptors whose expression is finely tuned throughout NK cell differentiation and licensing. For ontological reasons and similarities in terms of transcription factors and secreted cytokines, NK cells have b...

GUT ABSTRACTIONS. A PHILOSOPHICAL STUDY FOR THE PRESENT OF FOOD.

This dissertation investigates the role of the microbial turn within the domain of nutrition, focusing on the emergence of microbiome science and its centrality to envisioning food futures. By adopting a philosophical approach that conceptualizes philosophy as a form of negotiation, the research explores how diverse ontologies structure the categories and concepts shaping our engagement with food, including knowledge, values, norms, and practices. Specifically, the study examines two distinct...

UNDERSTANDING METASTASIS MIXED - TREATMENT RESPONSES THROUGH GENOMIC ANALYSES.

Early and metastatic breast cancers can exhibit heterogeneity, among patients and even within the same individual. Response to therapy in metastatic breast cancer patients with multiple metastases can also be heterogeneous, with different degrees of responsiveness to the same drug(s) across metastatic sites, termed "mixed response," within the same patient. If the variability of this treatment response is influenced by intrinsic tumor characteristics of metastatic lesions and/or the micro...

CARDIOVASCULAR AUTONOMIC IMPAIRMENT IN GBA PARKINSONIAN PATIENTS

Background: Mutations in the Beta-glucocerebrosidase (GBA) gene are the most common genetic risk factor for Parkinson’s disease (PD). GBA-associated PD (GBA-PD) has been linked to a higher prevalence of non-motor symptoms compared to idiopathic PD (I-PD), raising the question of whether autonomic dysfunction is more frequent or expressed differently in GBA-PD patients. Objectives: This study aimed to investigate cardiovascular autonomic function in GBA-PD patients compared to I-PD patients. ...

IDENTIFICATION OF GENETIC VARIANTS THROUGH WHOLE EXOMESEQUENCING IN PHENOTYPES WITH SKELETAL CLASS IIMALOCCLUSION BAD RESPONDERS

Skeletal malocclusions are complex craniofacial growth and developmental problems due to hereditary and environmental factors. They are a set of human morphologic characteristics that both exceed or present deficiency of maxillary and mandibular dimensions, resulting in an improper relationship of the jaws that distorts the balance of the face. Class II malocclusion is one of the most frequent orthodontic issues as it occurs in about one-third of the Western European population. It can resul...

THE ROLE OF MOLECULAR SIGNATURES IN COMPLICATED CELIAC DISEASE

Introduction: Refractory celiac disease (RCD) is defined as the persistence of symptoms and villous atrophy despite adherence to a gluten-free diet (GFD). Based on their molecular signatures, aberrant intraepithelial lymphocytes (aIELs) and monoclonal TCRγ rearrangement, RCD patients are differentiated into RCD type 1 (RCD1) and RCD type 2 (RCD2). This distinction is challenging but essential, as RCD2 is associated with enteropathy-associated lymphoma (EATL) and a poor prognosis, with no effe...

PEPTIDOGLYCAN REMODELLING FACTORS: KEY PLAYERS IN CELL DIVISION AND HOMEOSTASIS MAINTENANCE OF ESCHERICHIA COLI

In Escherichia coli, the structural integrity and coordinated growth of the cell envelope are crucial for survival, especially under environmental stress conditions. The lipopolysaccharide-containing outer membrane (OM) acts as a selective barrier against toxic molecules and provides additional mechanical support that complements the role traditionally attributed to the cell wall. Coordination between the OM and peptidoglycan (PG) growth is essential for maintaining cell envelope stability, p...

ANTIBODY-DRUG CONJUGATES FOR THE TREATMENT OF BREAST CANCER.

Background: Trastuzumab deruxtecan (T-DXd) and trastuzumab emtansine (T-DM1) are anti-HER2 antibody-drug conjugates (ADCs) which have shown robust efficacy for treating breast cancer. For both ADCs, however, we lack effective biomarkers to predict outcomes from pre-treatment samples. Methods: To unveil predictive biomarkers for ADCs, we first evaluated 5-year outcomes in a prospective trial (ATEMPT) testing adjuvant T-DM1 in patients with stage I HER2+ breast cancer, and reviewed real-worl...

MIR-181A/B INHIBITION AS A NEW STRATEGY FOR MITOCHONDRIAL DISEASE TREATMENT

Mitochondrial diseases (MDs) are a group of rare inherited disorders caused by defective oxidative phosphorylation (OXPHOS) and defined by a wide range of clinical phenotypes. MDs show extreme genetic heterogeneity, which makes the development of efficient treatments particularly difficult. Indeed, despite recent progress, no effective therapies are currently available. Gene/mutation-independent approaches targeting downstream affected pathways are highly needed, considering their genetic het...

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Istituto
  • Università degli Studi di Milano5939
Data di pubblicazione
  • 2020 - 20251482
  • 2010 - 20193810
  • 2000 - 2009640
  • 1990 - 19996
  • 1989 - 19891
Settore disciplinare
  • Settore BIO/11 - Biologia Molecolare353
  • Settore BIO/10 - Biochimica311
  • Settore MED/04 - Patologia Generale288
  • Settore BIO/14 - Farmacologia280
  • Settore CHIM/06 - Chimica Organica190
  • Settore INF/01 - Informatica184
  • Settore BIO/09 - Fisiologia138
  • Settore BIO/13 - Biologia Applicata123
  • Settore FIS/03 - Fisica della Mat...120
  • Settore SPS/04 - Scienza Politica105
Accesso al fulltext
  • open4778
  • no fulltext611
  • internalNetwork301
  • embargoed239
  • partially open5
  • reserved5