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Università degli Studi di Milano: [5979] Istituto

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Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 1 a 20 di 5.979
Istituto Anno di pubblicazione Titolo Autore file(s)
Università degli Studi di Milano 2025 MARKER-BASED CRISPR SCREENINGS TO CHARACTERIZE KINASES CONTROLLING MACROPHAGE ACTIVATION -
Università degli Studi di Milano 2025 ELUCIDATING THE IMPACT OF ASCITES ON HIGH GRADE SEROUS OVARIAN CANCER THROUGH MULTIPLE IN VITRO PATIENT-SPECIFIC MODELS -
Università degli Studi di Milano 2025 INSIGHTS INTO THE SELECTION AND FUNCTION OF COPY-NUMBER ALTERATIONS DURING CANCER EVOLUTION -
Università degli Studi di Milano 2025 UNEQUAL EXPERIENCES: HOW SOCIAL ENVIRONMENTS SHAPE PEOPLE¿S ATTITUDES TOWARDS INEQUALITY -
Università degli Studi di Milano 2025 PRC2 GATEKEEPS THE BALANCE BETWEEN DIRECT AND INDIRECT NEUROGENESIS AND CONTROLS NEURONAL MIGRATION DURING HUMAN CORTICOGENESIS -
Università degli Studi di Milano 2025 ROLE OF IL-10 PRODUCING EOMES+ TR1-LIKE CELLS IN MELANOMA -
Università degli Studi di Milano 2025 THE IMPACT OF REPLICATION STRESS ON THE EPIGENOME OF MOUSE EMBRYONIC STEM CELLS -
Università degli Studi di Milano 2025 FROM MICRONUCLEI TO EMT: MOLECULAR MECHANISMS OF GENOMIC INSTABILITY AND CELLULAR PLASTICITY -
Università degli Studi di Milano 2025 CATALYTIC-INDEPENDENT FUNCTIONS OF KDM6A IN B CELL MATURATION AND IMMUNE REGULATION -
Università degli Studi di Milano 2025 DEVELOPMENT OF AN INTEGRATED METHODOLOGY TO ASSESS THE PRESENCE AND THE IMPACT OF (MICRO)PLASTICS ON THE RIVER BENTHIC COMMUNITY -
Università degli Studi di Milano 2025 THE ACQUISITION OF PHRASAL VERBS THROUGH ENHANCED AUDIOVISUAL CAPTIONS. IMPLICATIONS FOR THE DEVELOPMENT OF A SUBTITLING TOOL FOR EFL LEARNERS -
Università degli Studi di Milano 2025 MULTISTAKEHOLDER GOVERNANCE FOR SUSTAINABILITY.NORMATIVE INSIGHTS FROM A DELIBERATIVE PERSPECTIVE -
Università degli Studi di Milano 2025 RESHAPING THE RIGHT TO HEALTH IN A POST-PANDEMIC ERA: THE ROLE OF ENTERPRISES AND THE HEALTH& SUSTAINABILITY NEXUS -
Università degli Studi di Milano 2025 A MULTILEVEL EXPLORATION OF SCIENCE DYNAMICS WITH COMPUTATIONAL AND QUANTITATIVE TECHNIQUES. -
Università degli Studi di Milano 2025 YIELDING PHENOMENA IN MICROGEL SUSPENSIONS ACROSS LENGTH SCALES -
Università degli Studi di Milano 2024 UNE EXPERIENCE COMMUNALE. SOCIETE ET CULTURE POLITIQUE A MARSEILLE ENTRE XIIE ET XIIIE SIECLE. -
Università degli Studi di Milano 2025 IMPACT OF KETOGENIC DIET TREATMENT IN GLUT1 DEFICIENCY SYNDROME: DISCOVERY OF MOLECULAR MECHANISMS RESPONSIBLE FOR PHENOTYPE CHANGES IN BOTH PEDIATRIC AND ADULT PATIENTS -
Università degli Studi di Milano 2025 NOVEL INSIGHTS ON ALLAN-HERNDON-DUDLEY SYNDROME: TRANSCRIPTIONAL PROFILING AND FUNCTIONAL CHARACTERIZATION OF THREE GENETIC VARIANTS IN SLC16A2 GENE -
Università degli Studi di Milano 2025 PARADIGMI GEOGRAFICI E IDENTITARI IN ELIAS CANETTI ETHOMAS BERNHARD: UNA PROSPETTIVA COMPARATIVA -
Università degli Studi di Milano 2025 RECONSTRUCTING PHOENICIAN POTTERY PRODUCTION IN SARDINIA: A MULTI ANALYTICAL CHARACTERIZATION OF SAMPLES FROM THE SITE OF PANI LORIGA (8-7TH CENTURY BC) AND MONTE SIRAI (6-5TH CENTURY BC) -
Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 1 a 20 di 5.979
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Prodotti recenti

MARKER-BASED CRISPR SCREENINGS TO CHARACTERIZE KINASES CONTROLLING MACROPHAGE ACTIVATION

Identifying the complete set of components in cellular circuitries is a critical yet remarkably complex task in mammalian cells. Pathways involved in innate immune cell activation in response to various stimuli have been extensively characterized, but it remains unclear whether the full complement of regulators involved in signal transduction and the functional interplay among them have been identified. Kinases form the backbone of most signal transduction cascades, and their pharmacologic...

ELUCIDATING THE IMPACT OF ASCITES ON HIGH GRADE SEROUS OVARIAN CANCER THROUGH MULTIPLE IN VITRO PATIENT-SPECIFIC MODELS

High-grade serous ovarian cancer (HGSOC) is a highly heterogeneous and aggressive malignancy characterized by marked inter-/intra-tumor variability and a dynamic tumor microenvironment (TME). The TME, and particularly ascitic fluid (AF), plays a critical role in OC progression by influencing tumor and stromal cell behavior, promoting metastasis and driving therapy resistance. Current in vitro models often fail to replicate the complexity of the TME, being limited in their ability to fully cap...

INSIGHTS INTO THE SELECTION AND FUNCTION OF COPY-NUMBER ALTERATIONS DURING CANCER EVOLUTION

Cancer evolution is a complex process mostly driven by genomic instability, including large- and small-scale alterations, such as copy-number alterations (CNAs) or single-nucleotide mutations, respectively. Those alterations play a critical role in tumor development, genetic diversity, and resistance to therapies. This thesis explores the selection and functional role of CNAs, aiming to uncover insights into how these alterations shape cancer evolution. By integrating computational analyses, ...

UNEQUAL EXPERIENCES: HOW SOCIAL ENVIRONMENTS SHAPE PEOPLE¿S ATTITUDES TOWARDS INEQUALITY

This dissertation investigates how social environments—particularly personal networks and socializing institutions—shape individuals' attitudes towards inequality. It fills a critical gap in distributive justice research by exploring the effects of the socioeconomic composition of acquaintances, social network size, and life course exposure to diverse social groups on perceptions of inequality, justice ideologies, and redistributive preferences. Through three empirical studies, this research...

PRC2 GATEKEEPS THE BALANCE BETWEEN DIRECT AND INDIRECT NEUROGENESIS AND CONTROLS NEURONAL MIGRATION DURING HUMAN CORTICOGENESIS

Weaver syndrome (WVS) is a rare, autosomal dominant multisystem disorder, characterized by pre- and post-natal overgrowth, macrocephaly, facial dysmorphisms and varying degrees of intellectual disability. WVS’ genetic cause was identified in heterozygous mutations in Polycomb repressive complex 2 (PRC2) components. This complex catalyzes the trimethylation of Lysine 27 on histone 3 (H3K27me3), thereby repressing transcription during embryonic development. However, our understanding of how PR...

ROLE OF IL-10 PRODUCING EOMES+ TR1-LIKE CELLS IN MELANOMA

The regulatory mechanisms that prevent the adaptive immune system’s ability to eradicate tumors are crucial for the development of effective cancer immunotherapies. In particular, the immunosuppressive functions of FOXP3+ T regulatory cells (Tregs) and EOMES+ type 1 regulatory T (Tr1) cells, which produce the anti-inflammatory cytokine IL-10, have been identified as key modulators of anti-tumor immunity. IL-10 plays a dual role in cancer, functioning as a checkpoint receptor agonist dur...

THE IMPACT OF REPLICATION STRESS ON THE EPIGENOME OF MOUSE EMBRYONIC STEM CELLS

Epigenetic reprogramming and chromatin structure guide differentiation and define cell identity during embryogenesis. To maintain cell identity and genome integrity, epigenetic marks are faithfully inherited during DNA replication through tightly coordinated processes. Our recent work demonstrated that disruption of DNA replication, known as replication stress, can expand the cell fate of mouse embryonic stem cells (mESCs) by activating totipotency and extra-embryonic pathways. However, the u...

FROM MICRONUCLEI TO EMT: MOLECULAR MECHANISMS OF GENOMIC INSTABILITY AND CELLULAR PLASTICITY

Chromosomal instability and its cellular consequences represent critical aspects of cancer progression and genomic instability. The research presented in this thesis encompasses two complementary projects, focusing on distinct yet interconnected molecular pathways. The first project investigates the role of the autophagic receptor p62 in regulating micronuclear integrity. Utilizing advanced methodologies, including proximity labeling and mass spectrometry, this study reveals how p62 recognize...

CATALYTIC-INDEPENDENT FUNCTIONS OF KDM6A IN B CELL MATURATION AND IMMUNE REGULATION

Kdm6a is an X-linked gene encoding a lysine demethylase involved in epigenetic regulation of gene expression. It catalyzes the demethylation of histone H3 lysine-27, counteracting the function of Polycomb Repressive Complex 2 (PRC2). Kdm6a plays a key role in transcriptional activation of genes that control cell differentiation during embryonic development and postnatal life. It is recurrently mutated in several solid and hematological cancers and is responsible for Kabuki syndrome. While Kdm...

DEVELOPMENT OF AN INTEGRATED METHODOLOGY TO ASSESS THE PRESENCE AND THE IMPACT OF (MICRO)PLASTICS ON THE RIVER BENTHIC COMMUNITY

Plastic pollution is one of the main environmental issues of the modern society since the development of synthetic polymers with exceptional chemical/physical characteristics in the 20th century led to a continuous production and use of these materials with a great increase in plastic wastes. Consequently, the mismanagement of the end-of-life plastic products induces a constant flux of these materials into the environment, especially in aquatic ecosystems. In this context, rivers are the main...

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Istituto
  • Università degli Studi di Milano5979
Data di pubblicazione
  • 2020 - 20251664
  • 2010 - 20193683
  • 2000 - 2009625
  • 1990 - 19996
  • 1989 - 19891
Settore disciplinare
  • Settore BIO/11 - Biologia Molecolare348
  • Settore BIO/10 - Biochimica300
  • Settore MED/04 - Patologia Generale288
  • Settore BIO/14 - Farmacologia275
  • Settore CHIM/06 - Chimica Organica188
  • Settore INF/01 - Informatica181
  • Settore BIO/09 - Fisiologia133
  • Settore BIO/13 - Biologia Applicata123
  • Settore FIS/03 - Fisica della Mat...116
  • Settore BIO/18 - Genetica101
Accesso al fulltext
  • open4725
  • no fulltext602
  • embargoed345
  • internalNetwork301
  • partially open6