UNITesi

Università degli Studi di Milano: [9898] Istituto

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Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 21 a 40 di 9.898
Istituto Anno di pubblicazione Titolo Autore file(s)
Università degli Studi di Milano 2025 ASSESSING THE ROLE OF EXTERNAL PHOTOEVAPORATION OF PROTOPLANETARY DISCS IN NEARBY STAR-FORMING REGIONS -
Università degli Studi di Milano 2025 THE ROLE OF EXTRACELLULAR VESICLES IN HEART DISEASES -
Università degli Studi di Milano 2025 PLASMA JNK3 AS A NOVEL PERIPHERAL BIOMARKER IN ALZHEIMER'S AND PARKINSON'S DISEASES: EARLY DIAGNOSIS AND DISEASE MONITORING -
Università degli Studi di Milano 2025 NOVEL INSIGHTS INTO GENETIC AND ENVIRONMENTAL DETERMINANTS SHAPING GNRH NEURON BIOLOGY AND RELATED REPRODUCTIVE DISORDERS -
Università degli Studi di Milano 2025 STUDY OF THE BIOLOGICAL ACTIVITY OF PLANT EXTRACTS OBTAINED FROM BIOMASSES FROM WASTES OF THE AGRO-FOOD CHAIN WITH INNOVATIVE AND SUSTAINABLE METHODOLOGIES: RELEVANCE FOR CARDIOMETABOLIC HEALTH -
Università degli Studi di Milano 2025 DEFATTED SEED CAKES RECOVERY TO INCREASE BIOFUEL PRODUCTION SUSTAINABILITY FROM SECOND-GENERATION OIL-CROPS -
Università degli Studi di Milano 2025 PERIPHERAL BIOMARKERS AND THERAPEUTIC MODULATION OF PROTEOSTASIS PATHWAYS IN AMYOTROPHIC LATERAL SCLEROSIS -
Università degli Studi di Milano 2025 INSIGHT ON ANGPTL3 IMPACT ON HEPATIC METABOLISM AND FUNCTION -
Università degli Studi di Milano 2025 TARGETING NEUROINFLAMMATION TO RELIEVE FABRY DISEASE NEUROPATHIC PAIN:EFFICACY OF PROKINETICIN SYSTEM ANTAGONISM AND MICROGLIAL INHIBITION -
Università degli Studi di Milano 2025 ROLE OF HIGH DENSITY LIPOPROTEINS AGAINST PROSTATE CANCER -
Università degli Studi di Milano 2025 NEUROINFLAMMATION ACROSS BOUNDARIES: INSIGHTS FROM HUMAN ISCHEMIC STROKE AND BIOMATERIAL CRANIOPLASTY -
Università degli Studi di Milano 2025 RABPHILIN3A: FROM NMDA RECEPTOR MEMBRANE DYNAMICS TO NEURODEVELOPMENTAL DISORDERS -
Università degli Studi di Milano 2025 THE IMPACT OF VASCULAR SMOOTH MUSCLE CELL SENESCENCE ON MITOCHONDRIA DYSFUNCTION AND ANGIOGENESIS -
Università degli Studi di Milano 2025 IMPROVING THE CIRCULARITY OF BIODEGRADABLE BIOPLASTICS BY PRODUCING BIOGAS: A FULL-SCALE ASSESSMENT -
Università degli Studi di Milano 2025 AGRO-HYDROLOGICAL MODELS FOR THE ASSESSMENT OF INNOVATIVE IRRIGATION PRACTICES IN RICE AREAS -
Università degli Studi di Milano 2025 OPTIMIZED APPROACHES FOR LIQUID BIOPSY IN GLIOBLASTOMA PATIENTS -
Università degli Studi di Milano 2025 GENETIC DISSECTION OF PLANT ARCHITECTURE TRAITS IN HORDEUM VULGARE (BARLEY) -
Università degli Studi di Milano 2025 LINKING CHROMATIN REMODELING TO MITOCHONDRIAL DYSFUNCTION: A ROLE FOR THE SMARCA5-MYC-TFAM AXIS IN HEPATOCELLULAR CARCINOMA -
Università degli Studi di Milano 2025 A DATA-DRIVEN PRIORITIZATION ALGORITHM FOR MEDICATION REVIEW IN OLDER ADULTS: FROM REAL-WORLD EVIDENCE TO CLINICAL PRACTICE -
Università degli Studi di Milano 2025 UNVEILING THE ADVERSE EFFECTS OF POLYSTYRENE NANOPLASTICS IN THE HUMAN-DERIVED HEPG2-OA STEATOTIC-LIKE MODEL, VALIDATING DYSFUNCTIONAL HUMAN-DERIVED SW872 ADIPOCYTE IN VITRO MODELS FOR THE STUDY OF CARDIOMETABOLIC DISEASES, AND ASSESSING TRIMETHYLAMINE N-OXIDE IN A PLIC STUDY SUB-COHORT -
Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 21 a 40 di 9.898
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INNOVATIVE MARKETING STRATEGIES AND TOOLS FOR THE WINE SECTOR - A FOCUS ON SPARKLING WINE FIRMS IN THE HO.RE.CA. CHANNEL

The wine sector is undergoing significant transformations, with consumption declining across most wine categories except for sparkling wines. Within this context, fine dining restaurants emerge as one of the most value-adding channels for wineries. Wine lists, often curated by sommeliers, serve not only as tools for sales but also as instruments to shape the dining experience. Given the central role of wine in restaurants, successful establishments tend to achieve different levels of consumer...

ESTABLISHING AN IN VITRO MODEL FOR CRISPR-CAS9 SCREENING OF INTERFERON EFFECTORS IN HBV INFECTION

Hepatitis B virus (HBV) is a hepatotropic virus that can cause both acute and chronic liver infection. According to the World Health Organization, 254 million people were living with chronic hepatitis B virus (CHB) infection in 2022, with approximately 1.2 million new cases each year. While vaccination prevents new infections, CHB still leads to cirrhosis and hepatocellular carcinoma, contributing to over one million deaths annually and underscoring the need for improved therapies (World Heal...

THE ROLE OF CD4+ T MEMORY SUBSETS IN HIV INFECTION: IMMUNE RESPONSE IN PEOPLE WITH HIV AND LATENCY ESTABLISHMENT

T lymphocytes comprise diverse subsets which differ in phenotype, function and maturation level. Among them, T memory stem cells (TSCM) represent the more developmentally immature subpopulation of the memory pool, endowed with longevity, self-renewing capacity and multipotency, other than recall capabilities. These features make them pivotal for maintaining durable immune memory and controlling persistent infections. In the context of vaccination, the induction of vaccine-specific TSCM is a...

¿NOVEL INSIGHTS INTO THE EXPERIMENTAL MODEL OF POST-FINASTERIDE SYNDROME: BEHAVIORAL ALTERATIONS AND THEIR MOLECULAR BASIS'

Finasteride, a 5α-reductase inhibitor widely prescribed for benign prostatic hyperplasia and androgenetic alopecia, has been associated with a spectrum of adverse effects in a subset of users. In some cases, these side effects persist even after drug discontinuation, resulting in a condition known as post-finasteride syndrome (PFS). PFS is characterized by sexual dysfunction, mood disturbances, cognitive impairment, and persistent alterations in neuroactive steroid levels. Despite increasing ...

DEVELOPMENT OF APTAMER-BASED ENTRY INHIBITORS TARGETING CONSERVED HOST RECEPTORS OF RESPIRATORY VIRUSES

Respiratory viruses represent a significant public health challenge, with both seasonal and emerging pathogens capable of causing severe disease, especially in vulnerable populations. Among these, Human Rhinoviruses (HRVs) and Coronaviruses (CoVs) are notable for their ability to exploit conserved host protein receptors to mediate cellular entry—a feature that presents an attractive target for therapeutic intervention. This thesis focuses on the preclinical development of Aptamer 6 (Apt6), ...

A NOVEL CLASS OF DECAHYDROQUINOXALINE-BASED CHIRAL PHOSPHORIC ACIDS

Chiral phosphoric acids (CPAs) have found extensive application in many chemical transformations, becoming invaluable tools for syn thesizing pharmaceuticals and natural products. This study introdu ces a novel class of CPAs based on a chiral decahydroquinoxaline scaffold. The synthetic strategy for the construction of the chiral backbone involves as a key step a completely stereoselective pina col coupling of Salen-like bisimines, obtained by condensation of different aromatic aldehyd...

PATHOGENETIC DEFINITION OF THE MECHANISMS UNDERLYING THE NOVEL FAMILY OF PLIN4 GENE EXPANSION-RELATED MYOPATHY

La miopatia causata da mutazione nel gene PLIN4 è una rara patologia caratterizzata da esordio tardivo e progressiva debolezza muscolare. Fino ad oggi, sono state identificate due mutazioni causative: un’espansione di blocchi di 99 nucleotidi e una duplicazione di 14 blocchi, identificata recentemente e caratterizzata durante il mio percorso di dottorato. Entrambi i riarrangiamenti interessano l’esone 5 del gene PLIN4 che codifica per l’elica amfipatica della proteina. Perilipina 4 appartiene...

KUPFFER CELLS¿ MITOCHONDRIAL PLASTICITY AFFECTS SYSTEMIC IMMUNO-METABOLISM

BACKGROUND: Kupffer cells (KCs) are hepatic resident macrophages that are essential for liver physiology and contribute to the development of metabolic-associated fatty liver disease (MAFLD). Due to their high plasticity, KCs can maintain immunotolerance and mediate cell-cell interaction within the hepatic niche, playing both an immune and metabolic role. As a result, KCs require large amounts of energy to perform their functions, which is why mitochondria turn out to be critical for their fu...

MODULATION OF TRPML1/TFEB PATHWAY FOR THE TREATMENT OF WILSON DISEASE

Wilson disease (WD) is an autosomal recessive disorder characterized by toxic copper accumulation in several tissues, resulting in hepatic and neurological impairment. WD is caused by mutations in the P-type ATPase copper transporting B (ATP7B) gene, responsible for copper supply to cuproproteins and removal of excessive copper by biliary excretion. In ATP7B-knockout cells, copper overload triggers autophagy and lysosomal exocytosis via transcription factor EB (TFEB), stimulating co...

RELATIVE A1-CONTRACTIBILITY OF SMOOTH SCHEMES AND EXOTIC MOTIVIC SPHERES

Uno dei problemi emergenti nella geometria algebrica è quello di caratterizzare lo spazio affine n-dimensionale A^n tra schemi affini regolari a meno di A^1-contrazione: una proprietà che rende gli spazi motivici omotopicamente equivalenti a un campo Spec k nella teoria dell'omotopia motivica. Recenti studi dimostrano che questa caratterizzazione vale in dimensioni n<3 su determinati campi. Nel nostro lavoro, estendiamo questa osservazione a schemi “ragionevoli” di base arbitraria, in dime...

Scopri
Istituto
  • Università degli Studi di Milano9790
Data di pubblicazione
  • 2020 - 20251861
  • 2010 - 20193747
  • 2000 - 20092371
  • 1990 - 19991642
  • 1986 - 1989138
Settore disciplinare
  • Settore BIO/11 - Biologia Molecolare384
  • Settore BIO/10 - Biochimica340
  • Settore BIO/14 - Farmacologia334
  • Settore MED/04 - Patologia Generale322
  • Settore INF/01 - Informatica223
  • Settore CHIM/06 - Chimica Organica211
  • Settore BIO/09 - Fisiologia165
  • Settore BIO/13 - Biologia Applicata145
  • Settore FIS/03 - Fisica della Mat...126
  • Settore BIO/18 - Genetica120
Accesso al fulltext
  • open4988
  • no fulltext4213
  • internalNetwork301
  • embargoed282
  • partially open6