UNITesi

Università degli Studi di Milano: [10112] Istituto

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Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 121 a 140 di 10.112
Istituto Anno di pubblicazione Titolo Autore file(s)
Università degli Studi di Milano 2025 ENDOCYTIC CONTROL OF CELL-AUTONOMOUS AND NON-CELL-AUTONOMOUS FUNCTIONS OF P53 -
Università degli Studi di Milano 2026 NEUROBIOLOGIA DEL SUICIDIO NEL DISTURBO DEPRESSIVO MAGGIORE: STUDIO MORFOLOGICO POST-MORTEM PER L¿INDAGINE DEL NETWORK GLIALE E VASCOLARE, CON ANALISI TOSSICOLOGICHE PER LA VALUTAZIONE DELL¿ADERENZA ALLA TERAPIA PSICHIATRICA -
Università degli Studi di Milano 2025 LINE1 RNAS COORDINATE RIBOSOME BIOGENESIS AND CHROMATIN ORGANIZATION TO SUSTAIN CELLULAR QUIESCENCE -
Università degli Studi di Milano 2025 INVESTIGATING EPIGENETIC MECHANISMS OF CHEMORESISTANCE IN OVARIAN CANCER: THE ROLE OF H3K27ME3 -
Università degli Studi di Milano 2025 EXPLORING THE MUTATIONAL LANDSCAPE OF MITOCHONDRIAL GENOME IN HEMATOLOGIC MALIGNANCIES -
Università degli Studi di Milano 2025 LARGE-SCALE METAGENOMIC ANALYSIS TO IDENTIFY HUMAN GUT MICROBIOME BIOMARKERS OF CARDIOMETABOLIC HEALTH -
Università degli Studi di Milano 2025 INVESTIGATING THE LINK BETWEEN HOMOLOGOUS RECOMBINATION PROTEIN BRCA2 AND DNA METHYLATION -
Università degli Studi di Milano 2025 CONTEXT SPECIFIC ROLE OF H2AK119UB1 IN ESTABLISHING AND MAINTAINING REPRESSION -
Università degli Studi di Milano 2025 RESOLVING TUMOR HETEROGENEITY THROUGH HIGH RESOLUTION MULTI-MODAL TRANSCRIPTOMICS: INTEGRATIVE SINGLE-CELL ATLASES AND GENERATIVE SPATIAL MODELING -
Università degli Studi di Milano 2025 SYNTHETIC-LETHAL PHARMACOLOGICAL INTERACTIONS IN MYC-DRIVEN LYMPHOMAS: A ROLE FOR GLUCOCORTICOIDS IN TARGETED THERAPY -
Università degli Studi di Milano 2025 MULTI-ORGAN FAILURE DRIVEN BY TELOMERE UNCAPPING -
Università degli Studi di Milano 2025 TARGETING TYPE-I PRMTS RESTORES PLATINUM SENSITIVITY IN OVARIAN CARCINOMA THROUGH MITOCHONDRIAL METABOLISM -
Università degli Studi di Milano 2025 RNA-MEDIATED PHASE SEPARATION OF 53BP1: CONNECTING CONDENSATE BIOPHYSICS TO DNA DAMAGE RESPONSE -
Università degli Studi di Milano 2025 ZSCAN4 AND REPLICATION STRESS: SAFEGUARDING GENOME STABILITY IN MOUSE EMBRYONIC STEM CELLS -
Università degli Studi di Milano 2026 SALICYLALDEHYDE-TAGGED PEPTIDES FOR THE REVERSIBLE-COVALENT ENGAGEMENT OF PROTEIN LYSINE RESIDUES -
Università degli Studi di Milano 2026 CHARACTERIZATION AND VALORISATION OF MOUNTAIN PLANT GENETIC RESOURCES -
Università degli Studi di Milano 2026 LA RIVOLUZIONE DALLA PALESTINA ALL¿ITALIA: L¿ATTIVITÀ DELLE ORGANIZZAZIONI PALESTINESI IN ITALIA DAL 1967 AL 1982 -
Università degli Studi di Milano 2026 STRATEGIES TO TARGET HUMAN D-ASPARTATE OXIDASE AND MODULATE ENDOGENOUS D-ASPARTATE LEVELS IN SCHIZOPHRENIA -
Università degli Studi di Milano 2026 SUSTAINABLE LIVESTOCK PRODUCTION WITH SPECIAL FOCUS ON SWINE NUTRITION, FEED SAFETY, AND ENVIRONMENTAL ISSUES -
Università degli Studi di Milano 2026 NUTRITIONAL STRATEGIES FOR IMPROVING THE SUSTAINABILITY OF SWINE FARMING -
Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 121 a 140 di 10.112
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Prodotti recenti

REPROGRAMMING PROLIFERATION: MOLECULAR STRATEGIES AGAINST GLIOBLASTOMA & BACTERIAL PERSISTENCE

Glioblastoma and bacterial persistence, though biologically distinct, pose a shared clinical challenge due to their resilience against pharmaceutical intervention. Part One of this work aims to address limitations in the treatment of glioblastoma, which currently consists of tumour removal and placement of a solid chemotherapy into the resection cavity. This treatment is undoubtedly flawed due to insufficient surface coverage and the high rate of relapse that follows. Our work aims to develop...

SEMICLASSICAL VIBRATIONAL SPECTROSCOPY BEYOND POWER SPECTRA

Infrared (IR) spectroscopy is a fundamental technique for probing molecular structure, dynamics, and intermolecular interactions. However, the increasing spectral complexity of medium- and large-sized systems makes theoretical support essential for reliable spectral assignment. Semiclassical (SC) molecular dynamics offers an effective compromise between accuracy and computational cost, incorporating key quantum effects through the propagation of classical trajectories. Traditionally, SC vibra...

FOOD AND FEED SAFETY IN THE CIRCULAR ECONOMY

This thesis addresses the valorization of agri food co/by-products and former food products (FFPs) for their introduction into animal feed within a circular economy framework. Chapter 1 validated an HPLC-UV method for quantifying theobromine and caffeine, and assessed cocoa hulls (CHs) compliance with EU feed limits, while also characterising polyphenols and antioxidant potential; Chapter 2 profiled FFPs for nutrient composition and methylxanthine levels to estimate methylxanthines exposure ...

SMYD3: A PLAYER IN STEMNESS AND CHROMOSOME INSTABILITY IN TRIPLE NEGATIVE BREAST CANCER

La metilasi delle lisine SMYD3 risulta essere over espressa in diversi tipi di tumore, e legata alla transizione epitelio-mesenchimale (EMT) (1). Inoltre, le cellule staminali del cancro (CSCs) sono cellule iniziatrici del tumore importanti nella formazione di metastasi e correlate all’EMT (2). Il nostro obiettivo era dunque quello di studiare la possibile relazione tra le CSCs e SMYD3 nel cancro al seno triplo negativo (TNBC). I dati prodotti mostrano l’impatto del knock-out (KO) di SMYD3 ne...

INNOVATIVE APPROACHES TO PLANT PROTECTION AND PRODUCE SAFETY THROUGH HIGH-PRECISION PLANT MANAGEMENT SYSTEMS

In recent years, the growing need to minimize the environmental impact of agriculture has encouraged the development of sustainable crop protection strategies that combine biological efficacy, food safety, and the preservation of microbial biodiversity. Within this framework, the use of biocontrol agents (BCAs), ultraviolet (UV) radiation, and advanced diagnostic technologies have emerged as an innovative toolkit for integrated pest management, reducing reliance on conventional agrochemicals....

PVD COATING TREATMENT TOWARDS A SUSTAINABLE AND ECO-FRIENDLY MANUFACTURING SYSTEM

Modern industries face critical challenges of wear, corrosion, and short component lifetimes, all of which impose high environmental and economic costs. Sustainable coating solutions are therefore required to enhance durability while reducing waste and energy consumption. Physical Vapor Deposition (PVD) offers an eco-friendly approach, and in recent years high entropy alloys (HEAs) have emerged as promising candidates for protective coatings due to their exceptional mechanical and corrosion-r...

DEVELOPMENT OF NOVEL BIOTECHNOLOGICAL APPROACHES FOR ACCELERATING GENETIC GAIN IN THE BOVINE

Modern livestock production is increasingly challenged to improve reproductive efficiency while maintaining sustainability and animal welfare standards. Accelerating genetic gain in cattle (Bos taurus) is essential for breeding animals that are more resilient to climate change, more resistant to disease, and capable of higher meat and milk productivity—all while minimizing their environmental footprint. One possible strategy to achieve this goal is to significantly shorten the generati...

INVESTIGATION OF RESILIENCE AND ITS GENETICSTHROUGH THE USE OF LONGITUDINAL DATA

This thesis investigates resilience in dairy cattle using an integrated approach that combines phenotypic characterization, simulation of perturbations, and genomic analysis. The research was motivated by the need to breed animals capable of maintaining productivity amid the environmental and economic challenges facing modern agriculture. Thanks to close collaboration with a medium-large dairy farm in Northern Italy, we had access to a comprehensive dataset of daily milk records and genotype ...

VIRAL SAFETY EVALUATION OF BIOTECHNOLOGY PRODUCTS: DEVELOPMENT AND OPTIMIZATIONOF RELIABLE VIRAL CLEARANCE STRATEGIES

This manuscript brings together the research activities carried out throughout my doctoral program and reflects the dual nature of the project, which developed at the interface between academic research and industrial application. The thesis is part of a broader framework dedicated to the study, optimization, and validation of viral clearance strategies within downstream processing for monoclonal antibody (mAb) production, with the overarching goal of establishing procedures that are effe...

ADVANCES IN MEAN-FIELD OPTIMAL CONTROL VIA DYNAMIC PROGRAMMING EQUATIONS

In questa tesi di dottorato ci proponiamo di analizzare varie classi di problemi di controllo ottimo di tipo McKean-Vlasov con un approccio analitico, che consiste nella caratterizzazione della funzione valore di ciascun problema mediante un'opportuna equazione alle derivate parziali, detta equazione di Hamilton-Jacobi-Bellman (HJB). Poiché i coefficienti di un'equazione stocastica di McKean-Vlasov dipendono non solo dalle traiettorie della soluzione, ma anche dalla sua legge, l'equazione di ...

Scopri
Istituto
  • Università degli Studi di Milano10004
Data di pubblicazione
  • 2020 - 20262074
  • 2010 - 20193748
  • 2000 - 20092371
  • 1990 - 19991642
  • 1986 - 1989138
Settore disciplinare
  • Settore BIO/11 - Biologia Molecolare384
  • Settore BIO/10 - Biochimica340
  • Settore BIO/14 - Farmacologia334
  • Settore MED/04 - Patologia Generale322
  • Settore INF/01 - Informatica223
  • Settore CHIM/06 - Chimica Organica211
  • Settore BIO/09 - Fisiologia165
  • Settore BIO/13 - Biologia Applicata145
  • Settore FIS/03 - Fisica della Mat...126
  • Settore BIO/18 - Genetica120
Accesso al fulltext
  • open5097
  • no fulltext4213
  • embargoed386
  • internalNetwork301
  • partially open7