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Università degli Studi di Roma La Sapienza: [13933] Istituto

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Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 1 a 20 di 13.933
Istituto Anno di pubblicazione Titolo Autore file(s)
Università degli Studi di Roma La Sapienza 2026 Role of TP53 mutations and of MRD monitoring by IG/TR rearrangements in refining prognosis of KMT2A-rearranged adult B-lineage Acute Lymphoblastic Leukemia patients -
Università degli Studi di Roma La Sapienza 2026 Ancient mortars: from diagnostic investigations to FAIR modeling of scientific data -
Università degli Studi di Roma La Sapienza 2026 Development of GD2- and FAP- targeted CAR T-cell strategies to overcome tumor and stroma barriers in osteosarcoma -
Università degli Studi di Roma La Sapienza 2026 Preclinical pharmacological characterization of GLP-1 agonists, PPARα activators, and peripheral CB1 antagonists in the treatment of high-fat high-fructose diet–induced metabolic and neuroendocrine dysregulation -
Università degli Studi di Roma La Sapienza 2026 Targeting NADH homeostasis through GPD2 inhibition and metabolic stress induces tumor regression in colorectal cancer -
Università degli Studi di Roma La Sapienza 2026 Custom-engineered extracellular vesicles to counteract muscle degeneration -
Università degli Studi di Roma La Sapienza 2026 Reinforcement learning for wall modeling in large-eddy simulation -
Università degli Studi di Roma La Sapienza 2026 Soggetti anziani e con demenza: studi farmacoepidemiologici sull’uso e la sicurezza d’impiego di farmaci e prodotti di origine naturale -
Università degli Studi di Roma La Sapienza 2026 Alabastri inglesi in Italia. Censimento, committenze e fortuna -
Università degli Studi di Roma La Sapienza 2026 Pharmacological modulation of the gut microbiota and epithelial barrier: new therapeutic perspectives in obesity -
Università degli Studi di Roma La Sapienza 2026 Gene expression of monocytes and targeted protein biomarker assessment in patients with polymyalgia rheumatica -
Università degli Studi di Roma La Sapienza 2025 Development of kinetic inductance detectors for CMB experiments -
Università degli Studi di Roma La Sapienza 2026 TRA DUE CAPITALI. Arte e committenza aristocratica a Costantinopoli e Tessalonica nella prima età dei Paleologi (1261-1350 ca.) -
Università degli Studi di Roma La Sapienza 2026 Design of integrated circuits for D band and E band receivers -
Università degli Studi di Roma La Sapienza 2026 Pratiche di patrimonializzazione e narrazioni della pesca nella Calabria tirrenica -
Università degli Studi di Roma La Sapienza 2025 New insights into cosmological tensions -
Università degli Studi di Roma La Sapienza 2026 L'archivio storico del comune di Capua: storia, ordinamento e fruizione (secoli XV-XVIII) -
Università degli Studi di Roma La Sapienza 2026 Role of donor clonal hematopoiesis-related mutations in recipients’ immunologic recovery after allogeneic stem cell transplantation -
Università degli Studi di Roma La Sapienza 2026 Virological efficacy, immunological impact, and quality of life in People Living with HIV treated with Long-Acting Injectable Cabotegravir/Rilpivirine: a holistic approach -
Università degli Studi di Roma La Sapienza 2026 Musealizzazione di preesistenze architettoniche: restauro e nuovo uso in Italia dagli anni Settanta del Novecento ai primi anni Duemila -
Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 1 a 20 di 13.933
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Prodotti recenti

Role of TP53 mutations and of MRD monitoring by IG/TR rearrangements in refining prognosis of KMT2A-rearranged adult B-lineage Acute Lymphoblastic Leukemia patients

Acute lymphoblastic leukemia (ALL) with KMT2A::AFF1 t(4;11)(q21;q23) fusion represents a high-risk entity with poor prognosis in both pediatric and adult populations. In adults, KMT2A rearrangements account for approximately 5–10% of BCR-ABL1-negative cases and are typically associated with higher white blood cell counts, a pro-B immunophenotype, and older age. Despite comparable rates of complete remission (CR) and minimal residual disease (MRD) negativity after induction, KMT2A::AFF1-positi...

Ancient mortars: from diagnostic investigations to FAIR modeling of scientific data

This thesis concerns the study of mortars used in archaeological contexts located in areas characterized by high seismicity, specifically, the well-known sites of Pompeii and Hierapolis of Phrygia, as well as Carsulae and Narni in Umbria. The research focused on the diachronic evolution of raw material selection and production techniques for mortar-based materials, while also identifying the factors responsible for their remarkable durability. To this end, the mortars were characterized throu...

Development of GD2- and FAP- targeted CAR T-cell strategies to overcome tumor and stroma barriers in osteosarcoma

Osteosarcoma (OS) is one of the most aggressive pediatric malignancies, characterised by limited survival rates and poor outcomes in cases of relapsed or metastatic disease. Although chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of hematologic malignancies, its application to solid tumors has been hampered by antigen heterogeneity and the immunosuppressive tumour microenvironment (TME). Within this hostile niche, the stromal compartment, especially ...

Preclinical pharmacological characterization of GLP-1 agonists, PPARα activators, and peripheral CB1 antagonists in the treatment of high-fat high-fructose diet–induced metabolic and neuroendocrine dysregulation

Obesity is a multifaceted metabolic disorder increasingly recognized for its impact not only on peripheral systems such as lipid and glucose metabolism but also on central nervous system (CNS) health, including neurodegenerative processes. Chronic consumption of high-fat, high-fructose diets (HFHFD) leads to systemic metabolic dysfunction characterized by insulin resistance, dyslipidemia, hepatic steatosis, and neuroinflammation, ultimately contributing to cognitive impairment and a...

Targeting NADH homeostasis through GPD2 inhibition and metabolic stress induces tumor regression in colorectal cancer

Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide and is characterized by marked metabolic reprogramming to sustain tumor growth and survival. In this context, mitochondrial glycerol-3-phosphate dehydrogenase (GPD2), a key enzyme in the glycerophosphate shuttle, emerges as a critical regulator of redox balance. Through analysis of publicly available datasets and tumor samples from mouse models of intestinal tumorigenesis, we demonstrate that GPD2 is con...

Custom-engineered extracellular vesicles to counteract muscle degeneration

Rationale Muscular dystrophies are genetically inherited degenerative myopathies1.The most prevalent muscular dystrophies involve dystrophin and components of the dystrophin-associated protein complex (DAPC)2. Among them, Limb-Girdle Muscular Dystrophy type 2E (LGMD2E) is caused by mutations in the β-sarcoglycan (βSGC) gene, leading to skeletal and cardiac dysfunctions3. Intercellular communication plays a crucial role in muscle homeostasis, and growing evidence highlights the involvement of...

Reinforcement learning for wall modeling in large-eddy simulation

This work advances the field of large-eddy simulation (LES) for wall-bounded turbulence through four key contributions. We begin by conducting direct numerical simulations (DNS) of rotating turbulent pipe flow at friction Reynolds numbers up to $\Rey_\tau \approx 3000$, investigating the physical mechanisms underlying drag reduction induced by steady axial rotation. Next, we present CaLES, a graphics processing unit (GPU) accelerated LES solver featuring advanced subgrid-scale (SGS) models an...

Soggetti anziani e con demenza: studi farmacoepidemiologici sull’uso e la sicurezza d’impiego di farmaci e prodotti di origine naturale

Title: Elderly people and patients with dementia: pharmacoepidemiological studies on the use and safety of medicines and natural products Introduction: From a public health perspective, epidemiological studies need to be planned to improve scientific knowledge on the appropriate use of drugs and the safety of natural products in frail individuals, such as the elderly. The aim of this PhD thesis is to describe the in-depth studies carried out during the doctoral period, which had the common o...

Alabastri inglesi in Italia. Censimento, committenze e fortuna

Il censimento dei rilievi in alabastro inglese realizzati tra il XIV e il XVI secolo e attualmente conservati in Italia, ha l’obiettivo di analizzare le dinamiche di committenza, collezionismo e conservazione di questa peculiare produzione artistica nel contesto italiano. L’indagine ha portato alla realizzazione del primo catalogo di respiro nazionale dedicato agli alabastri inglesi medievali. Tale catalogo favorisce un approccio più sistematico alla loro analisi e alla loro collocazione nel ...

Pharmacological modulation of the gut microbiota and epithelial barrier: new therapeutic perspectives in obesity

Obesity represents one of the major health challenges of the twenty-first century, having reached epidemic proportions and profoundly impacting both health and the global economy. It is characterized by excessive adipose tissue (AT) accumulation and constitutes a risk factor for the development of metabolic syndrome, cardiovascular diseases, and neuropsychiatric disorders. Its etiology is multifactorial, but the westernized environment, characterized by easily accessible high-calorie foods an...

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Istituto
  • Università degli Studi di Roma La...13933
Data di pubblicazione
  • In corso di stampa19
  • 2020 - 20263797
  • 2010 - 20192619
  • 2000 - 20093971
  • 1990 - 19993202
  • 1980 - 1989266
Settore disciplinare
  • Settore BIO/11 - Biologia Molecolare101
  • Settore ICAR/14 - Composizione Ar...99
  • Settore SPS/08 - Sociologia dei P...99
  • Settore MED/04 - Patologia Generale77
  • Settore ING-INF/05 - Sistemi di E...74
  • Settore SPS/07 - Sociologia Generale70
  • Settore INF/01 - Informatica68
  • Settore BIO/10 - Biochimica64
  • Settore SECS-P/01 - Economia Poli...62
  • Settore ICAR/12 - Tecnologia dell...61
Accesso al fulltext
  • no fulltext6901
  • open5779
  • internalNetwork877
  • mixed237
  • embargoed126
  • partially open13