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Università degli Studi del Piemonte orientale "Amedeo Avogadro": [487] Istituto

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Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 1 a 20 di 487
Istituto Anno di pubblicazione Titolo Autore file(s)
Università degli Studi del Piemonte orientale "Amedeo Avogadro" 2024 Lifestyle Medicine for Longevity (LSM4Long) pragmatic randomized controlled trial: development and implementation of a combined lifestyle intervention for older people in Long-Term Care -
Università degli Studi del Piemonte orientale "Amedeo Avogadro" 2024 Immunocompatibility of metallic-ion doped bioactive glasses and titanium-based implants for musculoskeletal regeneration -
Università degli Studi del Piemonte orientale "Amedeo Avogadro" 2024 Rationally-driven targeting of dihydroorotate dehydrogenase: key enzyme of pyrimidine biosynthesis pathway -
Università degli Studi del Piemonte orientale "Amedeo Avogadro" 2024 Il vuoto e la differenza : decostruzione e vacuità della metafisica -
Università degli Studi del Piemonte orientale "Amedeo Avogadro" 2024 Pre-clinical evaluation of the aldehyde dehydrogenase 1A3 isoform as potential therapeutic target in malignant pleural mesothelioma -
Università degli Studi del Piemonte orientale "Amedeo Avogadro" 2024 Adsorbent materials prepared from natural resources for environmental applications -
Università degli Studi del Piemonte orientale "Amedeo Avogadro" 2024 Evaluation of potential predictive and prognostic biomarkers in patients with advanced lung cancer treated with immunotherapy -
Università degli Studi del Piemonte orientale "Amedeo Avogadro" 2024 XPO1 mutations identify a subgroup of early stage CLL patients characterized by shorter time to first treatment conceivably due to enhanced B cell receptor signaling -
Università degli Studi del Piemonte orientale "Amedeo Avogadro" 2024 The identification of the PYRIN domain as mediator of IFI16-TLR4 interaction reveals a new class of endogenous inflammatory molecules -
Università degli Studi del Piemonte orientale "Amedeo Avogadro" 2025 GWAS era in multiple sclerosis: an integrative approach to explore genotype/phenotype interaction -
Università degli Studi del Piemonte orientale "Amedeo Avogadro" 2024 Microbiota of Vitis vinifera cv. Barbera grapes: a focus on the mycobiota and a look at the culturable indigenous Saccharomyces spp. strains under three different experimental conditions in vineyard -
Università degli Studi del Piemonte orientale "Amedeo Avogadro" 2024 Il Consiglio Superiore della Magistratura e i principi di autonomia e indipendenza : garanzia o minaccia? -
Università degli Studi del Piemonte orientale "Amedeo Avogadro" 2024 Spaces of the Diaspora: urban form and cultural practices of Russian immigrants in Europe and Asia in the first half of the twentieth century -
Università degli Studi del Piemonte orientale "Amedeo Avogadro" 2023 La prossenia in età ellenistica: i decreti ateniesi dalla guerra lamiaca alla conquista romana -
Università degli Studi del Piemonte orientale "Amedeo Avogadro" 2024 Divenire cani: la soggettività canina nella letteratura anglofona vittoriana e modernista -
Università degli Studi del Piemonte orientale "Amedeo Avogadro" 2024 Cell therapy for hemophilia A -
Università degli Studi del Piemonte orientale "Amedeo Avogadro" 2015 Beta human papillomavirus infection and skin cancer in immunocompromised host -
Università degli Studi del Piemonte orientale "Amedeo Avogadro" 2018 Targeted therapies in lung adenocarcinomas: new methodologies and new markers -
Università degli Studi del Piemonte orientale "Amedeo Avogadro" 2014 Expression and distinct functional roles of AKT isoforms in malignant pleural mesothelioma cells -
Università degli Studi del Piemonte orientale "Amedeo Avogadro" 2021 Sex differences in hepatitis C virus infection: characterisation of 17,β-estradiol-modulated antiviral defences in an HCV cell culture system -
Prodotti della tipologia (ordinati per Data di deposito in Decrescente ordine): 1 a 20 di 487
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Prodotti recenti

Lifestyle Medicine for Longevity (LSM4Long) pragmatic randomized controlled trial: development and implementation of a combined lifestyle intervention for older people in Long-Term Care

Worldwide the population is rapidly aging, but this increasing in longevity does not completely mean an extension of healthy lifespan. Population ageing is an inevitable irreversible demographic transition resulting towards longer life and smaller families, as a result, the utilization of long-term care (LTC) facilities is soaring. Innovative and comprehensive strategies are needed to support the well-being and quality of life among LTC older individuals. In long-term care facilities the burd...

Immunocompatibility of metallic-ion doped bioactive glasses and titanium-based implants for musculoskeletal regeneration

Musculoskeletal disorders (MSDs) are conditions that can impair the body’s movement intissues of the musculoskeletal system. Since the risk to develop MSDs increases withage, its burden on patients and healthcare systems is expected to keep rising. Nowadays,the treatment of MSDs relies on ineffective drug administration and on surgery forbiomaterial implantation, as a short-term solution. Due to the need for new therapies, Iworked with two types of optimized biomaterials: doped bioactive glas...

Rationally-driven targeting of dihydroorotate dehydrogenase: key enzyme of pyrimidine biosynthesis pathway

Pyrimidine Biosynthesis Pathway (PBP) plays a pivotal role in nucleic acids metabolism and in cellular homeostasis; accordingly, it emerges as a promising source of therapeutically relevant targets. Among PBP enzymes, dihydroorotate dehydrogenase (DHODH) has been explored for the treatment of various conditions, including autoimmune disorders, acute myeloid leukemia and more recently, in host-pathogen directed therapies for infectious diseases. With this regard, human DHODH (hDHODH) has been ...

Il vuoto e la differenza : decostruzione e vacuità della metafisica

L’espressione “horror vacui” esplicita una tendenza complessiva e fondamentale della metafisica occidentale: quella, cioè, di “riempire” il vuoto. Ammettere la realtà del vuoto significherebbe infatti contraddire i capisaldi della metafisica stessa: la pienezza, la presenza, la linearità causale e perciò la continuità priva di salti dell’Essere. L’operazione decostruttiva avviata da Jacques Derrida, portando a emersione una differenza “più antica” dell’Essere, infrange proprio questi principî...

Pre-clinical evaluation of the aldehyde dehydrogenase 1A3 isoform as potential therapeutic target in malignant pleural mesothelioma

Malignant pleural mesothelioma (MPM) is a fatal asbestos-associated malignancy of the lung pleura. MPM is a tumor with poor prognosis, characterized by a long latency period and a life expectancy of 11-12 months after diagnosis. Few treatment options exist for MPM patients, which unfortunately have a low response rate to the first line chemotherapy (cisplatin and pemetrexed combination). Recent advances have led the FDA (Food and Drug Administration) to approve two immunotherapy agents (ipil...

Adsorbent materials prepared from natural resources for environmental applications

The research work developed in the Ph.D. is related to the development of porous solids for environmental applications. In particular, different types of low-cost natural resources and agricultural wastes were used as raw materials for the synthesis of improved adsorbent materials. From one side, a natural kaolinite clay was exploited as a starting material to obtain a nanosized siliceous material with an improved adsorption capacity toward cationic dyes from aqueous phase. On the other ...

Evaluation of potential predictive and prognostic biomarkers in patients with advanced lung cancer treated with immunotherapy

Background: Immune checkpoint inhibitors (ICIs) have significantly improved the outcome in patients with lung cancer. However, heterogeneity in clinical benefit and absence of a reliable biomarker still represent an unmet need. Metabolic reprogramming plays a critical role in cancer behaviour. In particular; heme- ossigenase-1 (HO-1) expression on monocytes may have a role in treatment resistance. Methods: "ImmunoEGA" is a prospective, observational study in patients with advanced tumors, ...

XPO1 mutations identify a subgroup of early stage CLL patients characterized by shorter time to first treatment conceivably due to enhanced B cell receptor signaling

Most early-stage chronic lymphocytic leukemia (CLL) patients do not require immediate treatment and are actively managed with watch & wait strategy. While few clinical and molecular factors predict treatment requirement, the impact of gene mutations in unknown. In this study, we examined a total of 1092 early- stage CLL cases, subdivided into a training group (N=295) and two validation cohorts (N=402 and N=395). Through NGS analysis, we identified XPO1 mutations as predictor of shorter ti...

The identification of the PYRIN domain as mediator of IFI16-TLR4 interaction reveals a new class of endogenous inflammatory molecules

IFI16 è stata collegata a varie funzioni biologiche come: la regolazione del ciclo cellulare, l'apoptosi, la segnalazione dei danni al DNA, identificazione e restrizione di virus. Varie malattie infiammatorie sono state inoltre associate all’anomala espressione e rilascio di IFI16 nello spazio extracellulare. L'ipotesi è che la sovra espressione di IFI16 avvenga in compartimenti tissutali in cui non è fisiologicamente espressa durante l'infiammazione. Conseguentemente, IFI16 viene rilasciato ...

GWAS era in multiple sclerosis: an integrative approach to explore genotype/phenotype interaction

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system; genetic studies have identified more than 200 MS risk loci, but the functional mechanisms remain unclear; indeed, the identification of genetic factors associated with MS phenotypes and disease progression is crucial. The first phase of this PhD focused on collecting a large dataset of genetic and environmental data to explore gene-environment interactions, with specific aims including: to study autoimmune comorbi...

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Istituto
  • Università degli Studi del Piemon...487
Data di pubblicazione
  • 2020 - 2025152
  • 2010 - 2019266
  • 2000 - 200968
  • 1997 - 19991
Settore disciplinare
  • Settore MED/04 - Patologia Generale38
  • Settore BIO/10 - Biochimica25
  • Settore BIO/14 - Farmacologia21
  • Settore CHIM/03 - Chimica General...17
  • Settore MED/15 - Malattie del Sangue16
  • Settore BIO/13 - Biologia Applicata13
  • Settore CHIM/06 - Chimica Organica13
  • Settore MED/07 - Microbiologia e ...12
  • Settore CHIM/01 - Chimica Analitica11
  • Settore CHIM/02 - Chimica Fisica11
Accesso al fulltext
  • open346
  • embargoed63
  • internalNetwork36
  • no fulltext28
  • reserved8
  • partially open4
  • mixed2